Effect of propranolol on capsular reaction around silicone implants in guinea pigs.
Abstract
[PURPOSE] To evaluate the effect of propranolol on capsular architecture around silicone implants by measuring the inflammation, capsular thickness, and collagen fiber density, using a guinea pig experimental model.
[METHODS] Thirty six adult male guinea pigs randomly divided into two groups (n=18) were used. Each one received a silicone implant with textured-surface. The capsular tissue around implants from untreated or treated animals with the beta-adrenoceptor antagonist propranolol (10 mg/kg, dissolved in daily water) were analyzed for inflammation by histological scoring, capsular thickness by computerized histometry, and collagen fibers type I and Type III density by picrosirius polarization at different time points (7, 14 or 21 days after silicone implantation).
[RESULTS] Propranolol treatment reduced inflammation and impaired capsular thickness and delayed collagen maturation around the textured implant.
[CONCLUSION] Propranolol reduces the risk of developing capsular contracture around silicone implants with textured surface.
[METHODS] Thirty six adult male guinea pigs randomly divided into two groups (n=18) were used. Each one received a silicone implant with textured-surface. The capsular tissue around implants from untreated or treated animals with the beta-adrenoceptor antagonist propranolol (10 mg/kg, dissolved in daily water) were analyzed for inflammation by histological scoring, capsular thickness by computerized histometry, and collagen fibers type I and Type III density by picrosirius polarization at different time points (7, 14 or 21 days after silicone implantation).
[RESULTS] Propranolol treatment reduced inflammation and impaired capsular thickness and delayed collagen maturation around the textured implant.
[CONCLUSION] Propranolol reduces the risk of developing capsular contracture around silicone implants with textured surface.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | capsular
|
scispacy | 1 | ||
| 해부 | capsular tissue
|
scispacy | 1 | ||
| 합병증 | capsular contracture
|
피막구축 | dict | 1 | |
| 재료 | silicone implant
|
실리콘 보형물 | dict | 1 | |
| 약물 | propranolol
|
C0033497
propranolol
|
scispacy | 1 | |
| 약물 | silicone
|
C0037114
silicones
|
scispacy | 1 | |
| 약물 | [PURPOSE]
|
scispacy | 1 | ||
| 약물 | picrosirius
|
scispacy | 1 | ||
| 질환 | inflammation
|
C0021368
Inflammation
|
scispacy | 1 | |
| 기타 | guinea pigs
|
scispacy | 1 | ||
| 기타 | capsular architecture
|
scispacy | 1 | ||
| 기타 | collagen
|
scispacy | 1 | ||
| 기타 | guinea pig
|
scispacy | 1 | ||
| 기타 | capsular
|
scispacy | 1 | ||
| 기타 | collagen fibers type I
|
scispacy | 1 | ||
| 기타 | Type III density by
|
scispacy | 1 |
MeSH Terms
Adrenergic beta-Antagonists; Animals; Breast Implants; Collagen Type I; Collagen Type III; Disease Models, Animal; Guinea Pigs; Humans; Implant Capsular Contracture; Implants, Experimental; Male; Propranolol; Random Allocation; Reproducibility of Results; Silicone Gels; Subcutaneous Tissue; Time Factors; Treatment Outcome
🔗 함께 등장하는 도메인
이 논문이 속한 카테고리와 같은 논문에서 자주 함께 다뤄지는 카테고리들
관련 논문
- Breast plastic surgery in perimenopausal and postmenopausal women: Menopause-informed counseling on screening, safety, and long-term breast health.
- Immediate one-stage subcutaneous breast reconstruction without ADM: A single-center 6-year experience.
- Does Pencil Beam Scanning Proton Therapy Impart a Higher Risk of Capsular Contracture when Compared with Intensity Modulated Photon Radiotherapy in the Post-Mastectomy Reconstruction Setting?
- Quantifying Silicone Leakage In Vivo: Validation of a Reproducible Histological Method for Breast Implant Surveillance.
- Prepectoral Breast Reconstruction Without Acellular Dermal Matrix and Mesh: A Prospective Cohort Study.