Prophylactic use of pentoxifylline (Trental) and vitamin E to prevent capsular contracture after implant reconstruction in patients requiring adjuvant radiation.
Abstract
[BACKGROUND] The combination of pentoxifylline (Trental) and vitamin E has been reported to reverse significant consequences of radiation after mastectomy with immediate reconstruction, such as severe capsular contracture or loss of implants. We questioned whether prophylactic use could prevent these consequences.
[METHODS] Thirty women with implants or tissue expanders after mastectomy that underwent adjuvant radiation were treated with Trental and vitamin E for 180 days. All subjects then entered a 12-month observational phase.
[RESULTS] Of the 26 evaluable subjects, 3 subjects required implant revisions. One due to malposition of the nonradiated breast and 2 were due to contracture (7.7%). There were no implant losses.
[CONCLUSIONS] The combination of Trental and vitamin E can prevent severe contracture and implant losses allowing for immediate reconstruction with implant or tissue expander even if radiation is planned after mastectomy.
[METHODS] Thirty women with implants or tissue expanders after mastectomy that underwent adjuvant radiation were treated with Trental and vitamin E for 180 days. All subjects then entered a 12-month observational phase.
[RESULTS] Of the 26 evaluable subjects, 3 subjects required implant revisions. One due to malposition of the nonradiated breast and 2 were due to contracture (7.7%). There were no implant losses.
[CONCLUSIONS] The combination of Trental and vitamin E can prevent severe contracture and implant losses allowing for immediate reconstruction with implant or tissue expander even if radiation is planned after mastectomy.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 합병증 | capsular contracture
|
피막구축 | dict | 2 | |
| 해부 | breast
|
유방 | dict | 1 | |
| 약물 | pentoxifylline
|
C0030899
pentoxifylline
|
scispacy | 1 | |
| 약물 | Trental
|
C0699487
TRENtal
|
scispacy | 1 | |
| 약물 | vitamin E
|
C0042874
vitamin E
|
scispacy | 1 | |
| 약물 | [BACKGROUND]
|
scispacy | 1 | ||
| 약물 | vitamin E for
|
scispacy | 1 | ||
| 약물 | [CONCLUSIONS]
|
scispacy | 1 | ||
| 질환 | contracture
|
C0009917
Contracture
|
scispacy | 1 | |
| 기타 | capsular
|
scispacy | 1 | ||
| 기타 | patients
|
scispacy | 1 | ||
| 기타 | women
|
scispacy | 1 | ||
| 기타 | tissue expanders
|
scispacy | 1 | ||
| 기타 | tissue expander
|
scispacy | 1 |
MeSH Terms
Adult; Breast Implantation; Breast Implants; Breast Neoplasms; Cohort Studies; Drug Therapy, Combination; Female; Humans; Implant Capsular Contracture; Mastectomy; Middle Aged; Pentoxifylline; Postoperative Period; Prognosis; Prospective Studies; Radiotherapy, Adjuvant; Risk Assessment; Treatment Outcome; Vitamin E
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