Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: a randomized, double blind, placebo-controlled trial.
💡 한 문장 핵심
다모증 치료에서 spironolactone, flutamide, finasteride의 효능 비교: 무작위 이중맹검 위약대조 시험.
🦱 탈모
🔵 RCT
무작위 임상시험
5/5 보강
TL;DR
After a 6-month course of therapy, the clinical efficacies of these drugs, at least at the doses used, are similar and are all effective in the treatment of hirsutism.
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· 인용됨 9
📑 인용한 논문 (6) ▾
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- Preparation and clinical evaluation of Finastride gel in the treatment of idiopathic Hirsu… Journal of drug assessment · 2015
- Interventions for hirsutism (excluding laser and photoepilation therapy alone). The Cochrane database of systematic reviews · 2015
- Adverse effects of 5α-reductase inhibitors: What do we know, don't know, and need to know? Reviews in endocrine & metabolic disorders · 2015
연도별 인용 (2012–2025) · 합계 86
OpenAlex 토픽 ·
Ovarian function and disorders
Hair Growth and Disorders
Sexual function and dysfunction studies
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
다모증(hirsutism) 치료에서 스피로노락톤(spironolactone, 100mg/일), 플루타마이드(flutamide, 250mg/일), 피나스테라이드(finasteride, 5mg/일) 세 가지 항안드로겐 약물의 효과를 위약과 객관적으로 비교하고자 함.
【방법】
다모증 여성 40명을 무작위 배정해 6개월간 위 3가지 약물 또는 위약으로 이중맹검 치료. 백선(linea alba)에서 뽑은 모발 5개의 최대 직경을 컴퓨터 보조 광학현미경으로 측정해 평균 모간 직경(hair shaft diameter)을 산출하고, 변형 페리먼-갤웨이(Ferriman-Gallwey, F-G) 점수로 임상 평가를 병행함.
【주요 결과】
6개월 후 세 약물 모두 모발 직경을 유의하게 감소시켰으며(스피로노락톤 -11.7%, 플루타마이드 -18.0%, 피나스테라이드 -12.6%), F-G 점수도 모두 감소(-41.0%, -38.9%, -31.6%). 약물 간 효과 차이는 통계적으로 유의하지 않았고, 위약군은 변화 없음. 즉 세 약물의 임상 효과는 서로 비슷함.
【임상적 시사점 (성형외과 의사 관점)】
다모증으로 내원하는 여성 환자에게 세 약물 모두 유효한 선택지이며 효과는 대등하므로, 부작용·금기·환자 상태(가임 여부 등)에 따라 약물을 선택할 수 있음. 단, 효과 발현에 최소 6개월이 필요하므로 레이저 제모 등 시술과 병행 시 약물치료의 충분한 기간과 환자 상담이 중요함.
To compare objectively the efficacies of spironolactone (100 mg/day), flutamide (250 mg/day), and finasteride (5 mg/day) in the treatment of hirsutism, 40 hirsute women were randomly assigned to double blind treatments with 1 of these 3 drugs or placebo for 6 months. Before and at the end of treatment, hirsutism was quantitatively measured in each subject by determination, by computer-assisted light microscopy, of the largest diameter of 5 hairs plucked from the linea alba. These measurements were averaged to produce a mean hair shaft diameter. For each subject, baseline and posttreatment assessments were carried out at the same time by an investigator blinded to both time and type of therapy. In addition, a semi-quantitative clinical evaluation was carried out by a modification of the Ferriman-Gallwey (F-G) scoring method, performed by a single investigator. At baseline the 4 groups of women had similar hair diameters and F-G scores. After 6 months of therapy all groups of subjects given active drugs showed reductions of their hair diameters, without statistically significant differences among groups (mean change +/- SEM, -11.7+/-5.6%, -18.0+/-6.1%, and -12.6+/-6.7%, respectively, in the spironolactone, flutamide, and finasteride groups). F-G scores were also significantly reduced in women receiving antiandrogen drugs, again without differences among groups (mean change, -41.0+/-5.5%, -38.9+/-7.2%, and -31.6+/-3.7%, respectively). No significant changes from baseline values were recorded by either hair diameter (-1.4+/-5.2%) or F-G score (+5.4+/-3.7%) assessment in the placebo group. In conclusion, spironolactone, flutamide, and finasteride are all effective in the treatment of hirsutism. After a 6-month course of therapy, the clinical efficacies of these drugs, at least at the doses used, are similar.
【연구 목적】 다모증(hirsutism) 치료에서 스피로노락톤(spironolactone, 100mg/일), 플루타마이드(flutamide, 250mg/일), 피나스테라이드(finasteride, 5mg/일) 세 가지 항안드로겐 약물의 효과를 위약과 객관적으로 비교하고자 함.
APA 7
Moghetti, P., Tosi, F., Tosti, A., Negri, C., Misciali, C., Perrone, F., Caputo, M., Muggeo, M., & Castello, R. (2000). Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: A randomized, double blind, placebo-controlled trial.. The Journal of clinical endocrinology and metabolism, 85(1), 89-94. https://doi.org/10.1210/jcem.85.1.6245
Vancouver
Moghetti P, Tosi F, Tosti A, Negri C, Misciali C, Perrone F, et al. Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: a randomized, double blind, placebo-controlled trial. Jour. clin. endo. meta.. 2000;85(1):89-94. doi:10.1210/jcem.85.1.6245
AMA 11
Moghetti P, Tosi F, Tosti A, Negri C, Misciali C, Perrone F, et al. Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: a randomized, double blind, placebo-controlled trial. Jour. clin. endo. meta.. 2000;85(1):89-94. doi:10.1210/jcem.85.1.6245
Chicago
Moghetti, P., Tosi, F., Tosti, A., Negri, C., Misciali, C., Perrone, F., Caputo, M., Muggeo, M., and Castello, R.. 2000. "Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: a randomized, double blind, placebo-controlled trial." The Journal of clinical endocrinology and metabolism 85 (1): 89-94. https://doi.org/10.1210/jcem.85.1.6245
MLA 9
Moghetti, P., et al. "Comparison of spironolactone, flutamide, and finasteride efficacy in the treatment of hirsutism: a randomized, double blind, placebo-controlled trial." The Journal of clinical endocrinology and metabolism, vol. 85, no. 1, 2000, pp. 89-94. doi:10.1210/jcem.85.1.6245.
PMID
10634370 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
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· 참조 0편 · 후속 5편
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