Microsurgery Treatment as an Optimal Management of Posterior Cerebral Artery Aneurysms: A Systematic Review and Meta-Analysis.

The choice of treatment of two modalities, open surgical or endovascular, in posterior cerebral artery (PCA) intracranial aneurysms must be taken based on their special characteristics. The objective of this study is to assess the potential superiority in outcomes, operative mortality, and clinical improvement after microsurgical and endovascular management repair in PCA intracranial aneurysms. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), we created this study, performing a systematic investigation on the PubMed database, with the last search carried out on June 12, 2016. The eligibility limitations were that only full text was used in the English language, and double-checking was applied. Extracted data was organized on a standard table form, including first author, publication year, general number of patients and patients at follow-up, mortality rate (with 30 days from the selecting treatment), improvement (showing postoperatively at the clinical progress (muscle strength, thinking ability, and disorientation, due to ischemic infarctions following parent vessel occlusion) for the patients of both modalities. There were eight articles that matched our study criteria. The total study population included 8,863 patients with an aneurysm, 184 (2.07%) of which had an aneurysm at the different segments of the PCA. The pooled results revealed no statistically significant difference between the two groups, in terms of mortality, but with substantial statistical results concerning clinical improvement. We concluded that the aneurysmal site and size do not influence the treatment outcome. However, clinical improvement was a statistically significant factor, demonstrating the superiority of open surgical management over endovascular treatment (EVT) for PCA aneurysms. The selection of the appropriate procedure for every case must be done based on its special characteristics.