Angular morphometric factors associated with intraoperative rupture in anterior communicating artery aneurysms: A prospective observational study.
2/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
37 patients with AComA aneurysms undergoing microsurgical clipping (Jan 2023-Dec 2025) were included.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
While hs-CRP and homocysteine reflect aneurysm inflammation, they do not predict intraoperative rupture. CT Angiography (CTA)-based morphometric parameters may assist in surgical risk stratification.
OpenAlex 토픽 ·
Intracranial Aneurysms: Treatment and Complications
Aortic aneurysm repair treatments
Vascular Procedures and Complications
[OBJECTIVE] To evaluate the association between angular morphometric parameters of anterior communicating artery (AComA) aneurysms and intraoperative rupture, and to assess the relationship of inflamm
- 표본수 (n) 13
- p-value p≤0.05
- p-value p=0.03
APA
Vemula Venkata Ramesh Chandra, Sree Datta Pradeep Kundum, et al. (2026). Angular morphometric factors associated with intraoperative rupture in anterior communicating artery aneurysms: A prospective observational study.. Journal of cerebrovascular and endovascular neurosurgery. https://doi.org/10.7461/jcen.2026.E2026.02.002
MLA
Vemula Venkata Ramesh Chandra, et al.. "Angular morphometric factors associated with intraoperative rupture in anterior communicating artery aneurysms: A prospective observational study.." Journal of cerebrovascular and endovascular neurosurgery, 2026.
PMID
41968445 ↗
Abstract 한글 요약
[OBJECTIVE] To evaluate the association between angular morphometric parameters of anterior communicating artery (AComA) aneurysms and intraoperative rupture, and to assess the relationship of inflammatory biomarkers (high-sensitivity C-reactive protein (hs-CRP), homocysteine) with aneurysm wall inflammation.
[METHODS] In this prospective observational study, 37 patients with AComA aneurysms undergoing microsurgical clipping (Jan 2023-Dec 2025) were included. All presented with aneurysmal subarachnoid hemorrhage (Fisher Grade ≥1). Morphometric parameters-aneurysm size, aspect ratio, size ratio, height-width ratio, vessel angle, flow angle, parent vessel angle, and inclination angle-were measured using computed tomography (CT) angiography and intraoperative microscopy. Aneurysm inflammation was defined by macroscopic features (wall thickening, discoloration, adhesions, friability). Preoperative hs-CRP and homocysteine levels were recorded. Patients were categorized into intraoperative rupture (n=13) and unruptured (n=24) groups. Statistical analysis used SPSS v26.0 (p≤0.05).
[RESULTS] Vessel angle (74.76±15.9 vs. 56.8±25.8; p=0.03) and flow angle (153.24±15.3 vs. 137.58±22.4; p=0.035) were significantly higher in ruptured cases. Parent vessel angle was higher in unruptured aneurysms (121.88±33.4 vs. 98.85±10.2; p=0.02). hs-CRP (68.86±57.3 vs. 30.86±49.8; p=0.032) and homocysteine (12.47±5.2 vs. 9.38±3.4; p=0.041) were elevated in inflamed aneurysms but showed no association with intraoperative rupture.
[CONCLUSIONS] Vessel, flow, and parent vessel angles are significantly associated with intraoperative rupture risk. While hs-CRP and homocysteine reflect aneurysm inflammation, they do not predict intraoperative rupture. CT Angiography (CTA)-based morphometric parameters may assist in surgical risk stratification.
[METHODS] In this prospective observational study, 37 patients with AComA aneurysms undergoing microsurgical clipping (Jan 2023-Dec 2025) were included. All presented with aneurysmal subarachnoid hemorrhage (Fisher Grade ≥1). Morphometric parameters-aneurysm size, aspect ratio, size ratio, height-width ratio, vessel angle, flow angle, parent vessel angle, and inclination angle-were measured using computed tomography (CT) angiography and intraoperative microscopy. Aneurysm inflammation was defined by macroscopic features (wall thickening, discoloration, adhesions, friability). Preoperative hs-CRP and homocysteine levels were recorded. Patients were categorized into intraoperative rupture (n=13) and unruptured (n=24) groups. Statistical analysis used SPSS v26.0 (p≤0.05).
[RESULTS] Vessel angle (74.76±15.9 vs. 56.8±25.8; p=0.03) and flow angle (153.24±15.3 vs. 137.58±22.4; p=0.035) were significantly higher in ruptured cases. Parent vessel angle was higher in unruptured aneurysms (121.88±33.4 vs. 98.85±10.2; p=0.02). hs-CRP (68.86±57.3 vs. 30.86±49.8; p=0.032) and homocysteine (12.47±5.2 vs. 9.38±3.4; p=0.041) were elevated in inflamed aneurysms but showed no association with intraoperative rupture.
[CONCLUSIONS] Vessel, flow, and parent vessel angles are significantly associated with intraoperative rupture risk. While hs-CRP and homocysteine reflect aneurysm inflammation, they do not predict intraoperative rupture. CT Angiography (CTA)-based morphometric parameters may assist in surgical risk stratification.
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