Statistical optimization of hyaluronidase production by Ochrobactrum intermedium MEFS strain along with in vivo application in the treatment of aesthetic filler complications.
2/5 보강
TL;DR
This is the first report of using microbial hyase in filler injections, offering potential for treating aesthetic filler complications, and Histological analysis revealed that the HA filler was completely eliminated when hyase was used at a dosage of 60 U/mL.
OpenAlex 토픽 ·
Infections and bacterial resistance
Wound Healing and Treatments
Skin and Cellular Biology Research
This is the first report of using microbial hyase in filler injections, offering potential for treating aesthetic filler complications, and Histological analysis revealed that the HA filler was comple
APA
Fafy A. Mohammed, Mai A Ebraheem, et al. (2025). Statistical optimization of hyaluronidase production by Ochrobactrum intermedium MEFS strain along with in vivo application in the treatment of aesthetic filler complications.. International journal of biological macromolecules, 289, 138383. https://doi.org/10.1016/j.ijbiomac.2024.138383
MLA
Fafy A. Mohammed, et al.. "Statistical optimization of hyaluronidase production by Ochrobactrum intermedium MEFS strain along with in vivo application in the treatment of aesthetic filler complications.." International journal of biological macromolecules, vol. 289, 2025, pp. 138383.
PMID
39645129 ↗
Abstract 한글 요약
This study aims to optimize the production of microbial hyaluronidase (hyase) from Ochrobactrum intermedium MEFS strain using a statistical model and assess its effectiveness in degrading dermal filler in hairless mice. Plackett-Burman design identified nicotinic acid and CaBr as the main factors affecting hyase activity, with optimal concentrations of 5.51 μg/mL for nicotinic acid and 99.76 mM for CaBr, resulting in hyase activity of 320 U/mL, as determined by a central compound design. The purified hyase was applied to hairless mice to reverse dermal filler complications. Complete degradation occurred after 48 h with 60 U/mL and 72 h with 30 U/mL treatments. Histological analysis showed a strong inflammatory response (neutrophiles accumulation) 24 h post-injection, which shifted to moderate inflammation (mononuclear cells) after 14 days. Hyase treatment reduced inflammation in a dose-dependent manner, with 30 U/mL resulting in mild inflammation and 60 U/mL promoting tissue repair. Histological analysis also revealed that the HA filler was completely eliminated when hyase was used at a dosage of 60 U/mL. This approach has proven more effective in completely eliminating the filler and supporting tissue regeneration. This is the first report of using microbial hyase in filler injections, offering potential for treating aesthetic filler complications.
추출된 의학 개체 (NER)
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 시술 | filler
|
필러 주입술 | dict | 4 | |
| 시술 | dermal filler
|
필러 주입술 | dict | 2 | |
| 시술 | ha filler
|
필러 주입술 | dict | 1 | |
| 재료 | ha
|
히알루론산 | dict | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
함께 등장하는 도메인
이 논문이 속한 카테고리와 같은 논문에서 자주 함께 다뤄지는 카테고리들
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- SpNeigh: spatial neighborhood and differential expression analysis for high-resolution spatial transcriptomics.
- Key Considerations for Targeting in Pancreatic Cancer: Potential Impact on the Treatment Paradigm.
- The tumor microenvironment as a key regulator of radiotherapy response.
- Overcoming Chemoresistance in Glioblastoma: Mechanisms, Therapeutic Strategies, and Functional Precision Medicine.
- Advances in green-synthesized magnetic nanoparticles for targeted cancer therapy: mechanisms, applications, and future perspectives.
- SMURF2 in Anticancer Therapy: Dual Role in Carcinogenesis and Theranostics.
📖 비슷한 OA 논문 — 같은 카테고리, 무료 전문 가능
-
Review of the Adverse Effects Associated with Dermal Filler Treatments: Part I Nodules, Granuloma, and Migration.
TL;DRNon-vascular side effects are addressed, highlighting their onset, symptoms, and management strategies, and the comprehensive understanding and careful management are vital for min…
-
Adverse Effects Associated with Dermal Filler Treatments: Part II Vascular Complication.
TL;DRThis study investigates the mechanisms of vascular complications, categorizing them into extravascular compression and intravascular emboli, and highlights the need for meticulous …
- Global Aesthetics Consensus: Botulinum Toxin Type A--Evidence-Based Review, Emerging Concepts, and Consensus Recommendations for Aesthetic Use, Including Updates on Complications.
- Dermal fillers in aesthetics: an overview of adverse events and treatment approaches.
-
Restoring long-lasting midface volume in the Asian face with a hyaluronic acid filler: A randomized controlled multicenter study.
TL;DRHAVOL (Restylane® Volyme) is a flexible HA filler suited to contouring and volumizing the midface that is a minimally‐invasive alternative to surgery to volumize the cheeks.