"Non-Toxic" Proteins of the Botulinum Toxin Complex Exert In-vivo Toxicity.

Scientific reports 2016 Vol.6() p. 31043

Miyashita S, Sagane Y, Suzuki T, Matsumoto T, Niwa K, Watanabe T

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Abstract

The botulinum neurotoxin (BoNT) causes muscle paralysis and is the most potent toxin in nature. BoNT is associated with a complex of auxiliary "Non-Toxic" proteins, which constitute a large-sized toxin complex (L-TC). However, here we report that the "Non-Toxic" complex of serotype D botulinum L-TC, when administered to rats, exerts in-vivo toxicity on small-intestinal villi. Moreover, Serotype C and D of the "Non-Toxic" complex, but not BoNT, induced vacuole-formation in a rat intestinal epithelial cell line (IEC-6), resulting in cell death. Our results suggest that the vacuole was formed in a manner distinct from the mechanism by which Helicobacter pylori vacuolating toxin (VacA) and Vibrio cholerae haemolysin induce vacuolation. We therefore hypothesise that the serotype C and D botulinum toxin complex is a functional hybrid of the neurotoxin and vacuolating toxin (VT) which arose from horizontal gene transfer from an ancestral BoNT-producing bacterium to a hypothetical VT-producing bacterium.

추출된 의학 개체 (NER)

유형영어 표현한국어 / 풀이UMLS CUI출처등장
시술 botulinum toxin 보툴리눔독소 주사 dict 2

MeSH Terms

Animals; Apoptosis; Bacterial Proteins; Botulinum Toxins; Cell Line; Clostridium botulinum; Helicobacter pylori; Hemolysin Factors; Intestinal Mucosa; Multiprotein Complexes; Rats; Vacuoles; Vibrio cholerae

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