Self-perception of natural outcome, appearance, and emotional well-being after OnabotulinumtoxinA treatment for upper facial lines: Post hoc analysis across age and gender.
Abstract
[BACKGROUND] OnabotulinumtoxinA (onabotA) is indicated for upper facial lines (UFL). Fear of unnatural-looking outcomes is a frequently reported treatment barrier.
[AIMS] Examine patient-reported outcomes (PROs) after onabotA treatment for UFL.
[METHODS] A post hoc analysis was conducted on two 12-month pivotal studies of onabotA for forehead and glabellar lines (20 U each), with/without treatment of crow's feet lines (±24 U). This analysis used PROs from the Facial Line Satisfaction Questionnaire: Items 4 (natural look), 5 (treatment effect), 11 (met expectations), and Impact Domain (appearance and psychological impact). The analysis included 458 neurotoxin-naive adults achieving a ≥2-grade improvement in forehead line (FHL) severity on the Facial Wrinkle Scale at Day 30 (primary endpoint). [Corrections made on 28 December 2023, after first online publication: 'UFL' in the previous sentence has been corrected to 'forehead line (FHL)' in this version.] Data were further stratified into millennials and men.
[RESULTS] At Day 30, 90.5% of all participants, 94.6% of millennials, and 85.7% of men were satisfied with receiving a natural look. Millennials had higher odds of being satisfied with natural outcomes at Day 30. This measure remained > 80% for all groups throughout the 12 months. Additionally, ≥80% were satisfied with the treatment effect, and >90% reported results met expectations. At Day 30, ≥50% reported positive impacts on self-perceived appearance and psychological well-being, but millennials had higher, and men had lower odds of reporting these improvements.
[CONCLUSIONS] Participants achieving a ≥2-grade improvement in FHL severity after onabotA reported high satisfaction with natural outcomes and the treatment effect, with improved self-perceived appearance and psychological well-being. [Corrections made on 28 December 2023, after first online publication: 'UFL' in the previous sentence has been corrected to 'FHL' in this version.] These results may help aesthetic providers and patients address fears regarding unnatural results with onabotA.
[AIMS] Examine patient-reported outcomes (PROs) after onabotA treatment for UFL.
[METHODS] A post hoc analysis was conducted on two 12-month pivotal studies of onabotA for forehead and glabellar lines (20 U each), with/without treatment of crow's feet lines (±24 U). This analysis used PROs from the Facial Line Satisfaction Questionnaire: Items 4 (natural look), 5 (treatment effect), 11 (met expectations), and Impact Domain (appearance and psychological impact). The analysis included 458 neurotoxin-naive adults achieving a ≥2-grade improvement in forehead line (FHL) severity on the Facial Wrinkle Scale at Day 30 (primary endpoint). [Corrections made on 28 December 2023, after first online publication: 'UFL' in the previous sentence has been corrected to 'forehead line (FHL)' in this version.] Data were further stratified into millennials and men.
[RESULTS] At Day 30, 90.5% of all participants, 94.6% of millennials, and 85.7% of men were satisfied with receiving a natural look. Millennials had higher odds of being satisfied with natural outcomes at Day 30. This measure remained > 80% for all groups throughout the 12 months. Additionally, ≥80% were satisfied with the treatment effect, and >90% reported results met expectations. At Day 30, ≥50% reported positive impacts on self-perceived appearance and psychological well-being, but millennials had higher, and men had lower odds of reporting these improvements.
[CONCLUSIONS] Participants achieving a ≥2-grade improvement in FHL severity after onabotA reported high satisfaction with natural outcomes and the treatment effect, with improved self-perceived appearance and psychological well-being. [Corrections made on 28 December 2023, after first online publication: 'UFL' in the previous sentence has been corrected to 'FHL' in this version.] These results may help aesthetic providers and patients address fears regarding unnatural results with onabotA.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | upper facial lines
|
scispacy | 1 | ||
| 해부 | facial lines
|
scispacy | 1 | ||
| 해부 | glabellar lines
|
scispacy | 1 | ||
| 해부 | feet lines
|
scispacy | 1 | ||
| 해부 | forehead line
|
scispacy | 1 | ||
| 약물 | OnabotulinumtoxinA
|
scispacy | 1 | ||
| 약물 | [BACKGROUND] OnabotulinumtoxinA
|
scispacy | 1 | ||
| 약물 | onabotA
→ OnabotulinumtoxinA
|
scispacy | 1 | ||
| 약물 | [CONCLUSIONS] Participants
|
scispacy | 1 | ||
| 질환 | FHL
→ forehead line
|
scispacy | 1 | ||
| 질환 | PROs
→ patient-reported outcomes
|
scispacy | 1 | ||
| 기타 | forehead
|
scispacy | 1 | ||
| 기타 | crow
|
scispacy | 1 | ||
| 기타 | ±24 U
|
scispacy | 1 | ||
| 기타 | FHL
→ forehead line
|
scispacy | 1 | ||
| 기타 | men
|
scispacy | 1 | ||
| 기타 | patients
|
scispacy | 1 |
MeSH Terms
Adult; Male; Humans; Botulinum Toxins, Type A; Neuromuscular Agents; Patient Satisfaction; Cosmetic Techniques; Double-Blind Method; Forehead; Self Concept; Skin Aging; Treatment Outcome