Frontal fibrosing alopecia: a clinical review of 36 patients.
4/5 보강
TL;DR
Treatment options for patients with Frontal fibrosing alopecia vary among clinicians, and there are no evidence‐based studies to guide treatment, thus, treatment options varied among clinicians.
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
36 patients with FFA, the largest cohort to date.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Treatment responses to hydroxychloroquine, doxycycline and mycophenolate mofetil were assessed using the LPPAI.
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· 인용됨 44
📑 인용한 논문 (6) ▾
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연도별 인용 (2012–2025) · 합계 179
OpenAlex 토픽 ·
Hair Growth and Disorders
Mesenchymal stem cell research
Systemic Sclerosis and Related Diseases
Abstract 🌐 Abstract
[BACKGROUND] Frontal fibrosing alopecia (FFA) is a primary lymphocytic cicatricial alopecia with a distinctive clinical pattern of progressive frontotemporal hairline recession. Currently, there are no evidence-based studies to guide treatment for patients with FFA; thus, treatment options vary among clinicians.
[OBJECTIVES] We report clinical findings and treatment outcomes of 36 patients with FFA, the largest cohort to date. Further, we report the first evidence-based study of the efficacy of hydroxychloroquine in FFA using a quantitative clinical score, the Lichen Planopilaris Activity Index (LPPAI).
[METHODS] A retrospective case note review was performed of 36 adult patients with FFA. Data were collected on demographics and clinical findings. Treatment responses to hydroxychloroquine, doxycycline and mycophenolate mofetil were assessed using the LPPAI. Adverse events were monitored.
[RESULTS] Most patients in our cohort were female (97%), white (92%) and postmenopausal (83%). Apart from hairline recession, 75% also reported eyebrow loss. Scalp pruritus (67%) and perifollicular erythema (86%) were the most common presenting symptom and sign, respectively. A statistically significant reduction in signs and symptoms in subjects treated with hydroxychloroquine (P < 0·05) was found at both 6- and 12-month follow up.
[CONCLUSIONS] In FFA, hairline recession, scalp pruritus, perifollicular erythema and eyebrow loss are common at presentation. Despite the limitations of a retrospective review, our data reveal that hydroxychloroquine is significantly effective in reducing signs and symptoms of FFA after both 6 and 12 months of treatment. However, the lack of a significant reduction in signs and symptoms between 6 and 12 months indicates that the maximal benefits of hydroxychloroquine are evident within the first 6 months of use.
[OBJECTIVES] We report clinical findings and treatment outcomes of 36 patients with FFA, the largest cohort to date. Further, we report the first evidence-based study of the efficacy of hydroxychloroquine in FFA using a quantitative clinical score, the Lichen Planopilaris Activity Index (LPPAI).
[METHODS] A retrospective case note review was performed of 36 adult patients with FFA. Data were collected on demographics and clinical findings. Treatment responses to hydroxychloroquine, doxycycline and mycophenolate mofetil were assessed using the LPPAI. Adverse events were monitored.
[RESULTS] Most patients in our cohort were female (97%), white (92%) and postmenopausal (83%). Apart from hairline recession, 75% also reported eyebrow loss. Scalp pruritus (67%) and perifollicular erythema (86%) were the most common presenting symptom and sign, respectively. A statistically significant reduction in signs and symptoms in subjects treated with hydroxychloroquine (P < 0·05) was found at both 6- and 12-month follow up.
[CONCLUSIONS] In FFA, hairline recession, scalp pruritus, perifollicular erythema and eyebrow loss are common at presentation. Despite the limitations of a retrospective review, our data reveal that hydroxychloroquine is significantly effective in reducing signs and symptoms of FFA after both 6 and 12 months of treatment. However, the lack of a significant reduction in signs and symptoms between 6 and 12 months indicates that the maximal benefits of hydroxychloroquine are evident within the first 6 months of use.
Treatment options for patients with Frontal fibrosing alopecia vary among clinicians, and there are no evidence‐based studies to guide treatment, thus, treatment options varied among clinicians.
APA 7
Samrao, A., Chew, A. L., & Price, V. (2010). Frontal fibrosing alopecia: A clinical review of 36 patients.. The British journal of dermatology, 163(6), 1296-300. https://doi.org/10.1111/j.1365-2133.2010.09965.x
Vancouver
Samrao A, Chew AL, Price V. Frontal fibrosing alopecia: a clinical review of 36 patients. Brit. jour. derm.. 2010;163(6):1296-300. doi:10.1111/j.1365-2133.2010.09965.x
AMA 11
Samrao A, Chew AL, Price V. Frontal fibrosing alopecia: a clinical review of 36 patients. Brit. jour. derm.. 2010;163(6):1296-300. doi:10.1111/j.1365-2133.2010.09965.x
Chicago
Samrao, A., Chew, A. L., and Price, V.. 2010. "Frontal fibrosing alopecia: a clinical review of 36 patients." The British journal of dermatology 163 (6): 1296-300. https://doi.org/10.1111/j.1365-2133.2010.09965.x
MLA 9
Samrao, A., et al. "Frontal fibrosing alopecia: a clinical review of 36 patients." The British journal of dermatology, vol. 163, no. 6, 2010, pp. 1296-300. doi:10.1111/j.1365-2133.2010.09965.x.
PMID
20698851 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
- Frontal Fibrosing Alopecia: A Review.
- Alopecia: evaluation and treatment.
- Frontal Fibrosing Alopecia: An Emerging Epidemic.
- Frontal fibrosing alopecia treatment options.
- Lichen planopilaris and frontal fibrosing alopecia: review and update of diagnostic and therapeutic …
- Frontal fibrosing alopecia: An update on the hypothesis of pathogenesis and treatment.
- Frontal Fibrosing Alopecia and Vitiligo: Coexistence or True Association?
- Perifollicular erythema as a trichoscopy sign of progression in frontal fibrosing alopecia.
- Inflammatory features of frontal fibrosing alopecia.
- Finasteride-mediated hair regrowth and reversal of atrophy in a patient with frontal fibrosing alope…
- Frontal fibrosing alopecia: efficacy of treatment modalities.
- Familial Cicatricial Alopecia: Report of Familial Frontal Fibrosing Alopecia and Fibrosing Alopecia …
- Lichen planopilaris epidemiology: a retrospective study of 80 cases.
- Study of the Thyroid Profile of Patients with Alopecia.
- Graft versus Host Disease Presenting as Fibrosing Alopecia in a Pattern Distribution: A Model for Pa…
- Case Report of Connubial Frontal Fibrosing Alopecia.
- Frontal Fibrosing Alopecia: An Observational Single-Center Study of 306 Cases.
- Clinical and Dermoscopic Approaches to Diagnosis of Frontal Fibrosing Alopecia: Results From a Multi…
- Optimal Management of Frontal Fibrosing Alopecia: A Practical Guide.
- Cutaneous Lupus Erythematosus Presenting as Frontal Fibrosing Alopecia: Report of 2 Patients.
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