Frontal fibrosing alopecia: a multicenter review of 355 patients.
💡 한 문장 핵심
전두부 반흔성 탈모: 355명 환자에 대한 다기관 리뷰.
4/5 보강
TL;DR
Eyelash loss, facial papules, and body hair involvement were associated with severe FFA, and antiandrogens were the most useful treatment.
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
355 patients (343 women [49 premenopausal] and 12 men) with a mean age of 61 years (range 23-86) were included.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSIONS] Eyelash loss, facial papules, and body hair involvement were associated with severe FFA. Antiandrogens were the most useful treatment.
📑 코퍼스 인용 관계
· 인용됨 98
📑 인용한 논문 (6) ▾
- Statement from the frontal fibrosing alopecia international expert alliance: SOFFIA 2024. Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
- Frontal Fibrosing Alopecia: A Comprehensive Review with Recent Updates. Indian journal of dermatology · 2025
- Responsiveness of the Dermatology Life Quality Index and the Colombian Validated Version o… Skin appendage disorders · 2025
- A Critic of Retrospective Multicenter Studies in Clinical Trichology. International journal of trichology · 2025
- Histopathological characterization of inflammatory interparietal involvement in frontal fi… Frontiers in medicine · 2025
- Efficacy of Methotrexate Microinfusion in Scalp Lesions of Patients with Frontal Fibrosing… Skin appendage disorders · 2025
연도별 인용 (2014–2026) · 합계 443
OpenAlex 토픽 ·
Hair Growth and Disorders
Dermatologic Treatments and Research
Systemic Sclerosis and Related Diseases
Abstract 🌐 Abstract
[BACKGROUND] To our knowledge, there are no large multicenter studies concerning frontal fibrosing alopecia (FFA) that could give clues about its pathogenesis and best treatment.
[OBJECTIVE] We sought to describe the epidemiology, comorbidities, clinical presentation, diagnostic findings, and therapeutic choices in a large series of patients with FFA.
[METHODS] This retrospective multicenter study included patients given the diagnosis of FFA. Clinical severity was classified based on the recession of the frontotemporal hairline.
[RESULTS] In all, 355 patients (343 women [49 premenopausal] and 12 men) with a mean age of 61 years (range 23-86) were included. Early menopause was detected in 49 patients (14%), whereas 46 (13%) had undergone hysterectomy. Severe FFA was observed in 131 patients (37%). Independent factors associated with severe FFA after multivariate analysis were: eyelash loss, facial papules, and body hair involvement. Eyebrow loss as the initial clinical presentation was associated with mild forms. Antiandrogens such as finasteride and dutasteride were used in 111 patients (31%), with improvement in 52 (47%) and stabilization in 59 (53%).
[LIMITATIONS] The retrospective design is a limitation.
[CONCLUSIONS] Eyelash loss, facial papules, and body hair involvement were associated with severe FFA. Antiandrogens were the most useful treatment.
[OBJECTIVE] We sought to describe the epidemiology, comorbidities, clinical presentation, diagnostic findings, and therapeutic choices in a large series of patients with FFA.
[METHODS] This retrospective multicenter study included patients given the diagnosis of FFA. Clinical severity was classified based on the recession of the frontotemporal hairline.
[RESULTS] In all, 355 patients (343 women [49 premenopausal] and 12 men) with a mean age of 61 years (range 23-86) were included. Early menopause was detected in 49 patients (14%), whereas 46 (13%) had undergone hysterectomy. Severe FFA was observed in 131 patients (37%). Independent factors associated with severe FFA after multivariate analysis were: eyelash loss, facial papules, and body hair involvement. Eyebrow loss as the initial clinical presentation was associated with mild forms. Antiandrogens such as finasteride and dutasteride were used in 111 patients (31%), with improvement in 52 (47%) and stabilization in 59 (53%).
[LIMITATIONS] The retrospective design is a limitation.
[CONCLUSIONS] Eyelash loss, facial papules, and body hair involvement were associated with severe FFA. Antiandrogens were the most useful treatment.
Eyelash loss, facial papules, and body hair involvement were associated with severe FFA, and antiandrogens were the most useful treatment.
APA 7
S, V., Molina-Ruiz, A. M., C, S., Arias-Santiago, S., Rodrigues-Barata, A. R., Garnacho-Saucedo, G., Martorell-Calatayud, A., P, F., Grimalt, R., Aranegui, B., Grillo, E., Diaz-Ley, B., Salido, R., S, P., Serrano, S., Moreno, J. C., P, J., & Camacho, F. M. (2014). Frontal fibrosing alopecia: A multicenter review of 355 patients.. Journal of the American Academy of Dermatology, 70(4), 670-678. https://doi.org/10.1016/j.jaad.2013.12.003
Vancouver
S V, Molina-Ruiz AM, C S, Arias-Santiago S, Rodrigues-Barata AR, Garnacho-Saucedo G, et al. Frontal fibrosing alopecia: a multicenter review of 355 patients. Jour. Amer. Acad. Derm.. 2014;70(4):670-678. doi:10.1016/j.jaad.2013.12.003
AMA 11
S V, Molina-Ruiz AM, C S, Arias-Santiago S, Rodrigues-Barata AR, Garnacho-Saucedo G, et al. Frontal fibrosing alopecia: a multicenter review of 355 patients. Jour. Amer. Acad. Derm.. 2014;70(4):670-678. doi:10.1016/j.jaad.2013.12.003
Chicago
S, V., Molina-Ruiz, A. M., C, S., Arias-Santiago, S., Rodrigues-Barata, A. R., Garnacho-Saucedo, G., Martorell-Calatayud, A., P, F., Grimalt, R., Aranegui, B., and .... 2014. "Frontal fibrosing alopecia: a multicenter review of 355 patients." Journal of the American Academy of Dermatology 70 (4): 670-678. https://doi.org/10.1016/j.jaad.2013.12.003
MLA 9
S, V., et al. "Frontal fibrosing alopecia: a multicenter review of 355 patients." Journal of the American Academy of Dermatology, vol. 70, no. 4, 2014, pp. 670-678. doi:10.1016/j.jaad.2013.12.003.
PMID
24508293 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Adult
- Age Distribution
- Aged
- 80 and over
- Alopecia
- Azasteroids
- Biopsy
- Needle
- Cohort Studies
- Dutasteride
- Female
- Fibrosis
- Finasteride
- Forehead
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Multivariate Analysis
- Postmenopause
- Retrospective Studies
- Risk Assessment
- Severity of Illness Index
- Sex Distribution
… 외 12개
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 20
- Pathomechanisms of immune-mediated alopecia.
- Frequency of the Types of Alopecia at Twenty-Two Specialist Hair Clinics: A Multicenter Study.
- Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci incl…
- The Diagnosis and Treatment of Hair and Scalp Diseases.
- Frontal Fibrosing Alopecia: A Review.
- Frontal Fibrosing Alopecia: An Emerging Epidemic.
- Frontal fibrosing alopecia treatment options.
- Lichen planopilaris and frontal fibrosing alopecia: review and update of diagnostic and therapeutic …
- Frontiers in Lichen Planopilaris and Frontal Fibrosing Alopecia Research: Pathobiology Progress and …
- Frontal fibrosing alopecia: An update on the hypothesis of pathogenesis and treatment.
- Health-Related Quality of Life in Patients With Frontal Fibrosing Alopecia.
- Frontal Fibrosing Alopecia and Vitiligo: Coexistence or True Association?
- Distinct Trichoscopic Features of the Sideburns in Frontal Fibrosing Alopecia Compared to the Fronto…
- Successful Treatment of Facial Papules in Frontal Fibrosing Alopecia with Oral Isotretinoin.
- Finasteride-mediated hair regrowth and reversal of atrophy in a patient with frontal fibrosing alope…
- Frontal Fibrosing Alopecia and Increased Scalp Sweating: Is Neurogenic Inflammation the Common Link?
- Nail Involvement in Frontal Fibrosing Alopecia.
- Frontal fibrosing alopecia: a disease that remains enigmatic.
- Frontal fibrosing alopecia: efficacy of treatment modalities.
- Familial Cicatricial Alopecia: Report of Familial Frontal Fibrosing Alopecia and Fibrosing Alopecia …
같은 제1저자의 인용 많은 논문 (5)
- Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients.
- Frequency of the Types of Alopecia at Twenty-Two Specialist Hair Clinics: A Multicenter Study.
- Updated diagnostic criteria for frontal fibrosing alopecia.
- Oral minoxidil improves background hair thickness in lichen planopilaris.
- Hair transplant in frontal fibrosing alopecia: A multicenter review of 51 patients.
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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- 양성 전립선 비대증의 임상적 진행에 대한 doxazosin, finasteride 및 병용 요법의 장기 효과.
- 양성 전립선 비대증 환자에서 finasteride의 효과. The Finasteride Study Group.
- 양성 전립선 비대증 남성에서 급성 요폐의 위험과 수술적 치료 필요성에 대한 finasteride의 효과. Finasteride Long-Term Efficacy and Safety Study Group.
- 원형 탈모에 대한 전장유전체 연관성 연구는 선천면역과 적응면역 모두의 관여를 시사한다.