A Case Report of Cryoneurolysis With Factor VIII Administration for Cerebral Palsy-related Spasticity in a Patient With Hemophilia A.

Advances in rehabilitation science and practice 2025 Vol.14() p. 27536351241311802

Mumby G, Schatz L, Claridge E, Hashemi M, Winston P

관련 도메인

Abstract

Spasticity affects up to 80% of individuals with cerebral palsy and can lead to pain and difficulties with performing activities of daily living. If left untreated, spasticity can progress to contracture and neuro-orthopedic deformities. Cryoneurolysis is an emerging and mini-invasive ultrasound-guided technique that causes secondary axonotmesis of peripheral nerves through the formation of an ice ball and may result in months to years of improved range of motion and reduced pain in patients with spasticity. However, the safety of cryoneurolysis has not yet been established in patients with an increased bleeding risk secondary to Hemophilia A. We present a case of cryoneurolysis for cerebral palsy-related spasticity in a 14-year-old male with hemophilia A who previously had minimal benefit from botulinum toxin for increased elbow and wrist flexor tone with contracture. Fifteen minutes prior to cryoneurolysis, an IV infusion of 2000 IU of recombinant antihemophilic factor (FVIII) was administered for bleeding prophylaxis. Targets were identified with ultrasound guidance and nerve stimulation and cryoneurolysis was performed without bleeding complications or adverse events. There was an immediate improvement in tone and range of motion that was maintained at 3- and 8-month follow-ups with reported increased left arm function. This case suggests that cryoneurolysis is an effective mini-invasive procedure for spasticity that improves tone and range of motion and is safe for use in patients with Hemophilia A who receive adequate Factor VIII prophylaxis.

추출된 의학 개체 (NER)

유형영어 표현한국어 / 풀이UMLS CUI출처등장
시술 botulinum toxin 보툴리눔독소 주사 dict 1
해부 Cerebral scispacy 1
해부 elbow scispacy 1
해부 nerve scispacy 1
질환 Spasticity C0026838
Muscle Spasticity
scispacy 1
질환 A. Spasticity C0026838
Muscle Spasticity
scispacy 1
질환 cerebral palsy C0007789
Cerebral Palsy
scispacy 1
질환 pain C0030193
Pain
scispacy 1
질환 contracture C0009917
Contracture
scispacy 1
질환 neuro-orthopedic deformities scispacy 1
질환 axonotmesis C0476201
Axonotmesis
scispacy 1
질환 bleeding C0019080
Hemorrhage
scispacy 1
질환 cerebral palsy-related spasticity scispacy 1
질환 hemophilia A C0019069
Hemophilia A
scispacy 1
질환 Hemophilia A. scispacy 1
기타 Factor VIII scispacy 1
기타 Patient scispacy 1
기타 peripheral nerves scispacy 1
기타 patients scispacy 1
기타 male scispacy 1
기타 FVIII scispacy 1
기타 left arm scispacy 1

🔗 함께 등장하는 도메인

이 논문이 속한 카테고리와 같은 논문에서 자주 함께 다뤄지는 카테고리들

관련 논문