Botulinum toxin type A inhibits hyperalgesia in the rat masseter muscle in a carrageenan model of myofascial pain.
2/5 보강
TL;DR
Findings reveal that BoNT-A promotes antinociceptive effects in the masseter muscle during painful conditions independently of anti-inflammatory mechanisms.
🔎 핵심 키워드
보툴리눔독소 주사 ×2
myofascial
masseter muscle
intramuscular
masseters
Masseter
tissue
head withdrawal
전체 NER ↓
OpenAlex 토픽 ·
Botulinum Toxin and Related Neurological Disorders
Pain Mechanisms and Treatments
Myofascial pain diagnosis and treatment
Findings reveal that BoNT-A promotes antinociceptive effects in the masseter muscle during painful conditions independently of anti-inflammatory mechanisms.
APA
Ilana Dantas Neves, P Pinho, et al. (2025). Botulinum toxin type A inhibits hyperalgesia in the rat masseter muscle in a carrageenan model of myofascial pain.. Archives of oral biology, 173, 106218. https://doi.org/10.1016/j.archoralbio.2025.106218
MLA
Ilana Dantas Neves, et al.. "Botulinum toxin type A inhibits hyperalgesia in the rat masseter muscle in a carrageenan model of myofascial pain.." Archives of oral biology, vol. 173, 2025, pp. 106218.
PMID
40056789 ↗
Abstract 한글 요약
[OBJECTIVE] Previous studies have shown that botulinum toxin type A (BoNT-A) attenuates nociception, but the underlying mechanisms remain unclear. Studies of experimental pain in humans have also shown conflicting results. Carrageenan is commonly used to produce short-term acute inflammation and hyperalgesia in animal models, and the effect of BoNT-A on carrageenan-induced pain in the masseter muscle has not been studied. This study evaluated the antinociceptive and anti-inflammatory effects of intramuscular injection of BoNT-A in an experimental model of inflammatory pain in the masseter muscle of rats.
[DESIGN] Carrageenan (2 %) was injected into the masseters of sixty rats pretreated with three sessions of BoNT-A (3.5 U/kg) or daily with ibuprofen (40 mg/kg) for seven days. Masseter injected with saline was used as a control. An electronic von Frey anesthesiometer determined the head withdrawal threshold before carrageenan and at 5 h, 1, 3, and 7 days following administration. The masseters were processed for paraffin embedding and H&E staining and subjected to histomorphometric analysis 1 and 8 days after carrageenan administration.
[RESULTS] Pretreatments with BoNT-A or ibuprofen significantly decreased carrageenan-induced hyperalgesia. BoNT-A did not inhibit inflammation and tissue damage induced by carrageenan.
[CONCLUSIONS] These findings reveal that BoNT-A promotes antinociceptive effects in the masseter muscle during painful conditions independently of anti-inflammatory mechanisms.
[DESIGN] Carrageenan (2 %) was injected into the masseters of sixty rats pretreated with three sessions of BoNT-A (3.5 U/kg) or daily with ibuprofen (40 mg/kg) for seven days. Masseter injected with saline was used as a control. An electronic von Frey anesthesiometer determined the head withdrawal threshold before carrageenan and at 5 h, 1, 3, and 7 days following administration. The masseters were processed for paraffin embedding and H&E staining and subjected to histomorphometric analysis 1 and 8 days after carrageenan administration.
[RESULTS] Pretreatments with BoNT-A or ibuprofen significantly decreased carrageenan-induced hyperalgesia. BoNT-A did not inhibit inflammation and tissue damage induced by carrageenan.
[CONCLUSIONS] These findings reveal that BoNT-A promotes antinociceptive effects in the masseter muscle during painful conditions independently of anti-inflammatory mechanisms.
추출된 의학 개체 (NER)
시술
보툴리눔독소 주사 ×2
합병증
head withdrawal
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 시술 | botulinum toxin
|
보툴리눔독소 주사 | dict | 2 | |
| 해부 | myofascial
|
scispacy | 1 | ||
| 해부 | masseter muscle
|
scispacy | 1 | ||
| 해부 | intramuscular
|
scispacy | 1 | ||
| 해부 | masseters
|
scispacy | 1 | ||
| 해부 | Masseter
|
scispacy | 1 | ||
| 해부 | tissue
|
scispacy | 1 | ||
| 합병증 | head withdrawal
|
scispacy | 1 | ||
| 약물 | ibuprofen
|
C0020740
ibuprofen
|
scispacy | 1 | |
| 약물 | Carrageenan
|
scispacy | 1 | ||
| 약물 | BoNT-A
→ botulinum toxin type A
|
scispacy | 1 | ||
| 약물 | [DESIGN] Carrageenan
|
scispacy | 1 | ||
| 약물 | saline
|
scispacy | 1 | ||
| 질환 | hyperalgesia
|
C0020429
Hyperalgesia
|
scispacy | 1 | |
| 질환 | myofascial pain
|
C0553642
Soft tissue rheumatism
|
scispacy | 1 | |
| 질환 | pain
|
C0030193
Pain
|
scispacy | 1 | |
| 질환 | inflammation
|
C0021368
Inflammation
|
scispacy | 1 | |
| 질환 | anesthesiometer
|
scispacy | 1 | ||
| 질환 | tissue damage
|
C0010957
Tissue damage
|
scispacy | 1 | |
| 질환 | von Frey
|
scispacy | 1 | ||
| 기타 | Botulinum toxin type A
|
scispacy | 1 | ||
| 기타 | rat masseter muscle
|
scispacy | 1 | ||
| 기타 | BoNT-A
→ botulinum toxin type A
|
scispacy | 1 | ||
| 기타 | humans
|
scispacy | 1 | ||
| 기타 | anti-inflammatory
|
scispacy | 1 | ||
| 기타 | rats
|
scispacy | 1 | ||
| 기타 | H&E
|
scispacy | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
함께 등장하는 도메인
이 논문이 속한 카테고리와 같은 논문에서 자주 함께 다뤄지는 카테고리들
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