Electrical or magnetic nerve stimulation enhance the BoNT/A-mediated muscle paralysis.
Abstract
[BACKGROUND] Botulinum toxin type A (BoNT/A) is first-line treatment for muscle spasticity but the dose can be limited by side effects depending on the treated muscle mass and location. Stimulation of peripheral motor nerves upon BoNT/A injection into the innervated muscles may be a technique to increase the BoNT/A effect without increasing the dose. Our goal was to study the augmentation of the BoNT/A effect by transcutaneous electrical (TENS) or magnetic nerve stimulation (MS) in a mouse model.
[METHODS] The paralytic effect of BoNT/A with or without TENS was evaluated with the mouse digit abduction score (DAS) at 20, 30, and 40 U/kg. The paralytic effect of BoNT/A with or without peripheral MS was evaluated with the mouse DAS at 20 or 30 U/kg.
[RESULTS] After 20 U/kg BoNT/A treatment combined with TENS the DAS was higher and showed a longer duration of paralysis than without TENS. After 30 U/kg BoNT/A treatment combined with magnetic stimulation the DAS was higher than without magnetic stimulation.
[CONCLUSION] We established an electrical and a magnetic nerve stimulation protocol combined with BoNT/A treatment in mice. Combination of i.m. BoNT/A injection with TENS or MS demonstrated an enhanced BoNT/A effect as compared to non-stimulated groups. Despite limitations of the magnetic stimulation method in the mouse our data revives the discussion of BoNT/A effect augmentation by stimulating the injected muscles' efferent nerves during the BoNT/A uptake phase.
[METHODS] The paralytic effect of BoNT/A with or without TENS was evaluated with the mouse digit abduction score (DAS) at 20, 30, and 40 U/kg. The paralytic effect of BoNT/A with or without peripheral MS was evaluated with the mouse DAS at 20 or 30 U/kg.
[RESULTS] After 20 U/kg BoNT/A treatment combined with TENS the DAS was higher and showed a longer duration of paralysis than without TENS. After 30 U/kg BoNT/A treatment combined with magnetic stimulation the DAS was higher than without magnetic stimulation.
[CONCLUSION] We established an electrical and a magnetic nerve stimulation protocol combined with BoNT/A treatment in mice. Combination of i.m. BoNT/A injection with TENS or MS demonstrated an enhanced BoNT/A effect as compared to non-stimulated groups. Despite limitations of the magnetic stimulation method in the mouse our data revives the discussion of BoNT/A effect augmentation by stimulating the injected muscles' efferent nerves during the BoNT/A uptake phase.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 시술 | botulinum toxin
|
보툴리눔독소 주사 | dict | 1 | |
| 해부 | muscle
|
scispacy | 1 | ||
| 해부 | peripheral motor nerves
|
scispacy | 1 | ||
| 해부 | peripheral
|
scispacy | 1 | ||
| 해부 | muscles' efferent nerves
|
scispacy | 1 | ||
| 약물 | BoNT/A
→ Botulinum toxin type A
|
C0006050
botulinum toxin type A
|
scispacy | 1 | |
| 약물 | TENS
→ the BoNT/A effect by transcutaneous electrical
|
scispacy | 1 | ||
| 약물 | [BACKGROUND] Botulinum toxin type A
|
scispacy | 1 | ||
| 약물 | i.m
|
scispacy | 1 | ||
| 질환 | muscle paralysis
|
C0235062
Induction of neuromuscular blockade
|
scispacy | 1 | |
| 질환 | muscle spasticity
|
C0026838
Muscle Spasticity
|
scispacy | 1 | |
| 질환 | muscle mass
|
C0240417
muscle mass
|
scispacy | 1 | |
| 질환 | digit abduction
|
scispacy | 1 | ||
| 질환 | paralysis
|
C0522224
Paralysed
|
scispacy | 1 | |
| 기타 | BoNT/A
→ Botulinum toxin type A
|
scispacy | 1 | ||
| 기타 | muscles
|
scispacy | 1 | ||
| 기타 | TENS
→ the BoNT/A effect by transcutaneous electrical
|
scispacy | 1 | ||
| 기타 | mouse
|
scispacy | 1 | ||
| 기타 | mice
|
scispacy | 1 |
MeSH Terms
Animals; Botulinum Toxins, Type A; Mice; Transcutaneous Electric Nerve Stimulation; Paralysis; Magnetic Field Therapy; Muscle, Skeletal; Male; Neuromuscular Agents
📑 인용 관계
이 논문이 참조한 문헌 37
- Peripheral magnetic theta burst stimulation to muscles can effectively reduce spasticity: a randomiz…
- A practical guide to optimizing the benefits of post-stroke spasticity interventions with botulinum …
- Evaluation of independent versus integrated effects of reciprocal electrical stimulation and botulin…
- Combined effects of botulinum toxin type A and repetitive transcranial magnetic stimulation with int…
- Adjuvant treatments associated with botulinum toxin injection for managing spasticity: An overview o…
- Effect of electrical stimulation as an adjunct to botulinum toxin type A in the treatment of adult s…
- Injection of high dose botulinum-toxin A leads to impaired skeletal muscle function and damage of th…
외부 PMID 30건 (DB 미수집)
- PMID 10422600 ↗
- PMID 11600142 ↗
- PMID 11825307 ↗
- PMID 12195263 ↗
- PMID 1376680 ↗
- PMID 14449824 ↗
- PMID 14717608 ↗
- PMID 16901418 ↗
- PMID 17385940 ↗
- PMID 17583385 ↗
- PMID 17873826 ↗
- PMID 19016790 ↗
- PMID 19242626 ↗
- PMID 19454855 ↗
- PMID 205735 ↗
- PMID 20852412 ↗
- PMID 210882 ↗
- PMID 21832053 ↗
- PMID 23707612 ↗
- PMID 24561057 ↗
- PMID 24917588 ↗
- PMID 25323412 ↗
- PMID 25395371 ↗
- PMID 2594595 ↗
- PMID 27342571 ↗
- PMID 28356439 ↗
- PMID 30452892 ↗
- PMID 31507528 ↗
- PMID 32027791 ↗
- PMID 32268880 ↗
🔗 함께 등장하는 도메인
이 논문이 속한 카테고리와 같은 논문에서 자주 함께 다뤄지는 카테고리들
관련 논문
- Local therapeutic strategies for neurocutaneous dysesthesia: from capsaicin to cannabinoids.
- Comparative efficacy of intralesional therapies for keloid scars: a network meta-analysis.
- Adverse neurological events following botulinum toxin type A: A case series of post-injection seizures and paralysis.
- Decreased utilization of component separation techniques over time in complex abdominal wall reconstruction following introduction of preoperative botulinum toxin A.
- Current Perspectives on Pectoralis Minor Syndrome: A Narrative Review.