The role of the contractile fibroblast in the capsules around tissue expanders and implants.
Abstract
The occurrence, structure and contractility of myofibroblasts in the capsules around tissue expanders and static implants has been studied in the rat, pig and humans. The capsules showed a characteristic layered structure with myofibroblasts being the predominant cell type. Capsular strips contract in vitro in a manner characteristic of fibroblast contraction. The contractile ability decreased with the time since expander insertion; and increased with expander exposure, peri-expander infection and clinical evidence of adverse capsular contracture. An hypothesis is proposed that capsular contracture is analogous to wound contraction, and that intraimplant pressure usually inhibits capsular contraction. Evidence is shown from intraexpander pressure measurements to support this hypothesis. The clinical implications for tissue expansion and breast augmentation are discussed.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 합병증 | capsular contracture
|
피막구축 | dict | 2 | |
| 시술 | breast augmentation
|
유방성형술 | dict | 1 | |
| 해부 | myofibroblasts
|
scispacy | 1 | ||
| 해부 | cell
|
scispacy | 1 | ||
| 해부 | fibroblast
|
scispacy | 1 | ||
| 해부 | capsular
|
scispacy | 1 | ||
| 해부 | tissue
|
scispacy | 1 | ||
| 해부 | breast
|
유방 | dict | 1 | |
| 합병증 | wound
|
scispacy | 1 | ||
| 합병증 | infection
|
감염 | dict | 1 | |
| 질환 | peri-expander infection
|
scispacy | 1 | ||
| 질환 | adverse capsular contracture
|
scispacy | 1 | ||
| 기타 | tissue expanders
|
scispacy | 1 | ||
| 기타 | rat
|
scispacy | 1 | ||
| 기타 | pig
|
scispacy | 1 | ||
| 기타 | humans
|
scispacy | 1 | ||
| 기타 | capsular
|
scispacy | 1 |
MeSH Terms
Animals; Female; Fibroblasts; Foreign-Body Reaction; Humans; Mammaplasty; Postoperative Complications; Prostheses and Implants; Rats; Rats, Sprague-Dawley; Swine; Time Factors; Tissue Expansion Devices
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