[SERMs for treatment of osteoporosis: state-of-the-art and perspectives].
Abstract
Every year in France, we observe 60,000 vertebral fractures, 50,000 hip fractures and 35,000 wrist fractures. However, only 20% of these patients receive adequate pharmacologic therapy to prevent new fractures and their complications. At the present time, clinicians have not a perfect knowledge of the therapeutic class of SERMs (Selective Estrogen Receptor Modulators). In this paper, the authors show the strong capacity of these drugs to produce, in osteoporotic postmenopausal women, major therapeutic effects on bone (reduction of fracture risk), on breast (reduction of cancer risk), and without any side effects on arterial diseases except an increased risk of venous thromboembolism.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | breast
|
유방 | dict | 1 | |
| 해부 | bone
|
scispacy | 1 | ||
| 약물 | SERMs
→ Selective Estrogen Receptor Modulators
|
C0732611
Selective Estrogen Receptor Modulators
|
scispacy | 1 | |
| 질환 | osteoporosis
|
C0029456
Osteoporosis
|
scispacy | 1 | |
| 질환 | fractures
|
C0016658
Fracture
|
scispacy | 1 | |
| 질환 | fracture
|
C0016658
Fracture
|
scispacy | 1 | |
| 질환 | breast (reduction of cancer
|
scispacy | 1 | ||
| 질환 | venous thromboembolism
|
C1861172
Venous Thromboembolism
|
scispacy | 1 | |
| 질환 | osteoporotic postmenopausal women
|
scispacy | 1 | ||
| 질환 | cancer
|
scispacy | 1 | ||
| 기타 | SERMs
→ Selective Estrogen Receptor Modulators
|
scispacy | 1 | ||
| 기타 | arterial
|
scispacy | 1 |
MeSH Terms
Breast Neoplasms; Female; Fractures, Bone; France; Humans; Osteoporosis, Postmenopausal; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Tamoxifen
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