Human sodium iodide symporter (hNIS) in fibroadenoma breast--a immunohistochemical study.

Indian journal of experimental biology 2011 Vol.49(2) p. 113-7

Rai R, Shrivastava A, Tandon A, Godbole MM, Kumar S, Das V, Dwivedi V, Pal L

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Abstract

Human sodium iodide symporter (hNIS), responsible for the active transport of iodine is an integral plasma membrane glycoprotein present in the thyroid cells and extrathyroid tissues like breast and salivary glands. If its functional form is unequivocally shown in benign or malignant breast tissues, then it may serve as a basis for diagnosis and treatment using radioactive iodine. With an aim to analyze the hNIS expression in a distinct benign breast condition of fibroadenoma, biopsy proven fibroadenoma tissues, normal non-lactating breast tissue and biopsy proven infiltrating duct carcinoma tissues were examined for hNIS expression using immunohistochemistry. Out of 20 biopsy proven fibroadenoma tissues, 19 (95%) showed positivity for hNIS protein and only one was negative. Of these 10% were mildly positive, 50% cases were moderately positive and 35% showed intense positivity. None of the control tissue obtained from reduction mammoplasty specimens or normal breast tissues samples (5 cms away from the tumor) were positive, hNIS was also intensely positive in 9 out of 10 (90%) infiltrating duct carcinoma tissues and moderately positive in one case. These preliminary results show that hNIS was present in high frequency as demonstrated by immunohistochemistry in fibroadenoma breast.

추출된 의학 개체 (NER)

유형영어 표현한국어 / 풀이UMLS CUI출처등장
해부 breast 유방 dict 7
시술 reduction mammoplasty 유방성형술 dict 1
해부 plasma membrane glycoprotein scispacy 1
해부 thyroid cells scispacy 1
해부 extrathyroid tissues like breast scispacy 1
해부 salivary glands scispacy 1
해부 fibroadenoma tissues scispacy 1
해부 tissue scispacy 1
해부 breast tissues samples scispacy 1
합병증 biopsy proven scispacy 1
약물 sodium iodide C0037521
sodium iodide
scispacy 1
약물 iodine C0021968
iodine
scispacy 1
질환 fibroadenoma C0178421
Fibroadenoma of breast
scispacy 1
질환 infiltrating duct carcinoma C1134719
Invasive Ductal Breast Carcinoma
scispacy 1
질환 tumor C0027651
Neoplasms
scispacy 1
질환 fibroadenoma breast scispacy 1
질환 malignant breast tissues scispacy 1
질환 benign breast scispacy 1
질환 breast tissue scispacy 1
질환 duct carcinoma tissues scispacy 1
기타 Human sodium iodide symporter scispacy 1

MeSH Terms

Adolescent; Adult; Biopsy; Breast Neoplasms; Carcinoma; Female; Fibroadenoma; Humans; Immunohistochemistry; Middle Aged; Neoplasm Staging; Symporters; Young Adult; Sodium-Iodide Symporters

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