Effects of minoxidil 2% vs. cyproterone acetate treatment on female androgenetic alopecia: a controlled, 12-month randomized trial.
💡 한 문장 핵심
여성형 안드로겐성 탈모에서 미녹시딜 2% 대 사이프로테론 아세테이트 치료 효과: 대조군 포함 12개월 무작위 임상시험.
🦱 탈모
🔵 RCT
무작위 임상시험
4/5 보강
TL;DR
A small number of studies have demonstrated the androgen‐dependent character of female androgenetic alopecia, but there have been few controlled studies of therapies for alopECia in women.
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: isolated alopecia (Delta = 8
I · Intervention 중재 / 시술
cyproterone acetate 52 mg day-1 plus ethinyl oestradiol 35 microg for 20 of every 28 days
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
추출되지 않음
📑 코퍼스 인용 관계
· 인용됨 22
📑 인용한 논문 (6) ▾
- Updates in Treatment for Androgenetic Alopecia. Annals of dermatology · 2025
- Androgenetic Alopecia: An Update on Pathogenesis and Pharmacological Treatment. Drug design, development and therapy · 2025
- Role and Mechanisms of Phytochemicals in Hair Growth and Health. Pharmaceuticals (Basel, Switzerland) · 2023
- Recent Advances in Understanding of the Etiopathogenesis, Diagnosis, and Management of Hai… Journal of clinical medicine · 2023
- Efficacy of Dr. SKS Hair Booster Serum in the Treatment of Female Pattern Alopecia in Pati… Cureus · 2023
- Androgenetic Alopecia: Therapy Update. Drugs · 2023
연도별 인용 (2012–2026) · 합계 118
OpenAlex 토픽 ·
Hair Growth and Disorders
Acne and Rosacea Treatments and Effects
Ovarian function and disorders
Abstract 🌐 Abstract
[BACKGROUND] Hormone studies have demonstrated the androgen-dependent character of female androgenetic alopecia, but there have been few controlled studies of therapies for alopecia in women.
[OBJECTIVES] To compare topical minoxidil 2% and cyproterone acetate in the treatment of female alopecia.
[METHODS] Sixty-six women with female-pattern alopecia were randomly assigned for 12 cycles into two groups, 33 received two local applications (2 mL day-1) of topical minoxidil 2% plus combined oral contraceptive and 33 received cyproterone acetate 52 mg day-1 plus ethinyl oestradiol 35 microg for 20 of every 28 days.
[RESULTS] A mean reduction of 2.4 +/- 6.2 per 0.36 cm2 in hairs of diameter > 40 microm was observed in the cyproterone acetate group (P = 0.05) and a mean increase of 6.5 +/- 9 per 0.36 cm2 in the minoxidil group (P < 0.001). Comparison of the total number of hairs at 12 months and the body mass index (BMI) revealed a borderline positive correlation in the cyproterone acetate group (r = 0.39, P = 0.06) and a negative correlation in the minoxidil group (r = -0.42, P < 0.05). No significant difference was observed in the total number of hairs among cyproterone acetate patients according to the presence or absence of other symptoms of hyperandrogenism, whereas in the minoxidil group, the total number of new hairs was higher in patients with isolated alopecia (Delta = 8.1; P < 0.05). Variations in scalp seborrhoea were significant in both groups, but the result was better (for acne and hirsutism as well) in the cyproterone acetate group than in the minoxidil group (P < 0.001).
[CONCLUSIONS] Minoxidil treatment was more effective in the absence of other signs of hyperandrogenism, hyperseborrhoea, and menstrual cycle modifications when the BMI was low, and when nothing argued in favour of biochemical hyperandrogenism. Cyproterone acetate treatment was more effective when other signs were present and when the BMI was elevated, factors that favoured a diagnosis of biochemical hyperandrogenism.
[OBJECTIVES] To compare topical minoxidil 2% and cyproterone acetate in the treatment of female alopecia.
[METHODS] Sixty-six women with female-pattern alopecia were randomly assigned for 12 cycles into two groups, 33 received two local applications (2 mL day-1) of topical minoxidil 2% plus combined oral contraceptive and 33 received cyproterone acetate 52 mg day-1 plus ethinyl oestradiol 35 microg for 20 of every 28 days.
[RESULTS] A mean reduction of 2.4 +/- 6.2 per 0.36 cm2 in hairs of diameter > 40 microm was observed in the cyproterone acetate group (P = 0.05) and a mean increase of 6.5 +/- 9 per 0.36 cm2 in the minoxidil group (P < 0.001). Comparison of the total number of hairs at 12 months and the body mass index (BMI) revealed a borderline positive correlation in the cyproterone acetate group (r = 0.39, P = 0.06) and a negative correlation in the minoxidil group (r = -0.42, P < 0.05). No significant difference was observed in the total number of hairs among cyproterone acetate patients according to the presence or absence of other symptoms of hyperandrogenism, whereas in the minoxidil group, the total number of new hairs was higher in patients with isolated alopecia (Delta = 8.1; P < 0.05). Variations in scalp seborrhoea were significant in both groups, but the result was better (for acne and hirsutism as well) in the cyproterone acetate group than in the minoxidil group (P < 0.001).
[CONCLUSIONS] Minoxidil treatment was more effective in the absence of other signs of hyperandrogenism, hyperseborrhoea, and menstrual cycle modifications when the BMI was low, and when nothing argued in favour of biochemical hyperandrogenism. Cyproterone acetate treatment was more effective when other signs were present and when the BMI was elevated, factors that favoured a diagnosis of biochemical hyperandrogenism.
- p-value P = 0.05
- p-value P < 0.001
A small number of studies have demonstrated the androgen‐dependent character of female androgenetic alopecia, but there have been few controlled studies of therapies for alopECia in women.
APA 7
Vexiau, P., Chaspoux, C., Boudou, P., Fiet, J., Jouanique, C., Hardy, N., & Reygagne, P. (2002). Effects of minoxidil 2% vs. Cyproterone acetate treatment on female androgenetic alopecia: A controlled, 12-month randomized trial.. The British journal of dermatology, 146(6), 992-9. https://doi.org/10.1046/j.1365-2133.2002.04798.x
Vancouver
Vexiau P, Chaspoux C, Boudou P, Fiet J, Jouanique C, Hardy N, et al. Effects of minoxidil 2% vs. cyproterone acetate treatment on female androgenetic alopecia: a controlled, 12-month randomized trial. Brit. jour. derm.. 2002;146(6):992-9. doi:10.1046/j.1365-2133.2002.04798.x
AMA 11
Vexiau P, Chaspoux C, Boudou P, Fiet J, Jouanique C, Hardy N, et al. Effects of minoxidil 2% vs. cyproterone acetate treatment on female androgenetic alopecia: a controlled, 12-month randomized trial. Brit. jour. derm.. 2002;146(6):992-9. doi:10.1046/j.1365-2133.2002.04798.x
Chicago
Vexiau, P., Chaspoux, C., Boudou, P., Fiet, J., Jouanique, C., Hardy, N., and Reygagne, P.. 2002. "Effects of minoxidil 2% vs. cyproterone acetate treatment on female androgenetic alopecia: a controlled, 12-month randomized trial." The British journal of dermatology 146 (6): 992-9. https://doi.org/10.1046/j.1365-2133.2002.04798.x
MLA 9
Vexiau, P., et al. "Effects of minoxidil 2% vs. cyproterone acetate treatment on female androgenetic alopecia: a controlled, 12-month randomized trial." The British journal of dermatology, vol. 146, no. 6, 2002, pp. 992-9. doi:10.1046/j.1365-2133.2002.04798.x.
PMID
12072067 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 7/8 (88%)
· 참조 0편 · 후속 7편
이 논문을 인용한 후속 연구 20
- Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considera…
- Androgenetic Alopecia: Therapy Update.
- Androgenetic Alopecia: An Update of Treatment Options.
- Female pattern hair loss: current treatment concepts.
- Female pattern hair loss: A clinical, pathophysiologic, and therapeutic review.
- Female pattern alopecia: current perspectives.
- Female pattern hair loss.
- Role and Mechanisms of Phytochemicals in Hair Growth and Health.
- Interventions for female pattern hair loss.
- Recent Advances in Understanding of the Etiopathogenesis, Diagnosis, and Management of Hair Loss Dis…
- Female-pattern hair loss: therapeutic update.
- Pharmacologic interventions in aging hair.
- Understanding Pattern Hair Loss-Hair Biology Impacted by Genes, Androgens, Prostaglandins and Epigen…
- Hormonal therapy in female pattern hair loss.
- Androgenetic Alopecia: An Update on Pathogenesis and Pharmacological Treatment.
- Antiandrogenic Therapy with Ciproterone Acetate in Female Patients Who Suffer from Both Androgenetic…
- [Androgenetic alopecia. Diagnosis and therapy- a current review].
- Efficacy and Safety of a Topical Botanical in Female Androgenetic Alopecia: A Randomized, Single-Bli…
- Updates in Treatment for Androgenetic Alopecia.
- Efficacy of Dr. SKS Hair Booster Serum in the Treatment of Female Pattern Alopecia in Patients With …