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Molecular mechanisms of androgenetic alopecia.

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Experimental gerontology 📖 저널 OA 64.4% 2021: 0/5 OA 2022: 0/1 OA 2023: 1/3 OA 2024: 7/21 OA 2025: 31/31 OA 2026: 23/23 OA 2021~2026 2002 Vol.37(8-9) p. 981-90 피인용 77회 cited 343 RCR 6.04 Hair Growth and Disorders
TL;DR Current available treatment modalities with proven efficacy are oral finasteride, a competitive inhibitor of type 2 5 alpha-reductase, and topical minoxidil, an adenosine-triphosphate-sensitive potassium channel opener which has been reported to stimulate the production of vascular endothelial growth factor in cultured dermal papilla cells.
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PubMed DOI OpenAlex Semantic 마지막 보강 2026-05-10
📑 코퍼스 인용 관계 · 인용됨 77
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연도별 인용 (2012–2026) · 합계 277
OpenAlex 토픽 · Hair Growth and Disorders Dermatologic Treatments and Research melanin and skin pigmentation

Trüeb RM

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

Abstract

Androgenetic alopecia (AGA) is hereditary and androgen-dependent, progressive thinning of the scalp hair that follows a defined pattern. While the genetic involvement is pronounced but poorly understood, major advances have been achieved in understanding principal elements of the androgen metabolism involved: androgen-dependent processes are predominantly due to the binding of dihydrotestosterone (DHT) to the androgen receptor (AR). DHT-dependent cell functions depend on the availability of weak androgens, their conversion to more potent androgens via the action of 5 alpha-reductase, low enzymatic activity of androgen inactivating enzymes, and functionally active AR present in high numbers. The predisposed scalp exhibits high levels of DHT, and increased expression of the AR. Conversion of testosterone to DHT within the dermal papilla plays a central role, while androgen-regulated factors deriving from dermal papilla cells are believed to influence growth of other components of the hair follicle. Current available treatment modalities with proven efficacy are oral finasteride, a competitive inhibitor of type 2 5 alpha-reductase, and topical minoxidil, an adenosine-triphosphate-sensitive potassium channel opener which has been reported to stimulate the production of vascular endothelial growth factor in cultured dermal papilla cells. Since the clinical success rate of treatment of AGA with modulators of androgen metabolism or hair growth promoters is limited, sustained microscopic follicular inflammation with connective tissue remodeling, eventually resulting in permanent hair loss, is considered a possible cofactor in the complex etiology of AGA.
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Current available treatment modalities with proven efficacy are oral finasteride, a competitive inhibitor of type 2 5 alpha-reductase, and topical minoxidil, an adenosine-triphosphate-sensitive potass

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↓ .bib ↓ .ris
APA 7 RM, T. (2002). Molecular mechanisms of androgenetic alopecia.. Experimental gerontology, 37(8-9), 981-90. https://doi.org/10.1016/s0531-5565(02)00093-1
Vancouver RM T. Molecular mechanisms of androgenetic alopecia. Experimental gerontology. 2002;37(8-9):981-90. doi:10.1016/s0531-5565(02)00093-1
AMA 11 RM T. Molecular mechanisms of androgenetic alopecia. Experimental gerontology. 2002;37(8-9):981-90. doi:10.1016/s0531-5565(02)00093-1
Chicago RM, T.. 2002. "Molecular mechanisms of androgenetic alopecia." Experimental gerontology 37 (8-9): 981-90. https://doi.org/10.1016/s0531-5565(02)00093-1
MLA 9 RM, T.. "Molecular mechanisms of androgenetic alopecia." Experimental gerontology, vol. 37, no. 8-9, 2002, pp. 981-90. doi:10.1016/s0531-5565(02)00093-1.
PMID 12213548 ↗
DOI 10.1016/s0531-5565(02)00093-1

🏷️ 키워드 / MeSH 📖 같은 키워드 OA만

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그래프 OA 노드: 7/8 (88%) · 참조 0편 · 후속 7편

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