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Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil.

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FASEB journal : official publication of the Federation of American Societies for Experimental Biology 📖 저널 OA 42.2% 2021: 3/9 OA 2022: 5/11 OA 2023: 2/14 OA 2024: 10/40 OA 2025: 72/155 OA 2026: 59/115 OA 2021~2026 2008 Vol.22(6) p. 1725-36 피인용 36회 cited 158 RCR 3.43 Nerve injury and regeneration
TL;DR It is indicated that human follicular dermal papillae contain KATP channels that can respond to minoxidil and that tolbu tamide may suppress hair growth clinically; novel drugs designed specifically for these channels could treat hair disorders.
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PubMed DOI OpenAlex Semantic 마지막 보강 2026-05-10
📑 코퍼스 인용 관계 · 인용됨 36
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연도별 인용 (2012–2026) · 합계 149
OpenAlex 토픽 · Nerve injury and regeneration Hair Growth and Disorders Neurogenesis and neuroplasticity mechanisms

Shorter K, Farjo NP, Picksley SM, Randall VA

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Abstract

Hair disorders cause psychological distress but are generally poorly controlled; more effective treatments are required. Despite the long-standing use of minoxidil for balding, its mechanism is unclear; suggestions include action on vasculature or follicle cells. Similar drugs also stimulate hair, implicating ATP-sensitive potassium (K(ATP)) channels. To investigate whether K(ATP) channels are present in human follicles, we used organ culture, molecular biological, and immunohistological approaches. Minoxidil and tolbutamide, a K(ATP) channel blocker, opposed each other's effects on the growing phase (anagen) of scalp follicles cultured in media with and without insulin. Reverse transcriptase-polymerase chain reaction identified K(ATP) channel component gene expression including regulatory sulfonylurea receptors (SUR) SUR1 and SUR2B but not SUR2A and pore-forming subunits (Kir) Kir6.1 and Kir6.2. When hair bulb tissues were examined separately, epithelial matrix expressed SUR1 and Kir6.2, whereas both dermal papilla and sheath exhibited SUR2B and Kir6.1. Immunohistochemistry demonstrated similar protein distributions. Thus, human follicles respond biologically to K(ATP) channel regulators in culture and express genes and proteins for two K(ATP) channels, Kir6.2/SUR1 and Kir6.1/SUR2B; minoxidil only stimulates SUR2 channels. These findings indicate that human follicular dermal papillae contain K(ATP) channels that can respond to minoxidil and that tolbutamide may suppress hair growth clinically; novel drugs designed specifically for these channels could treat hair disorders.
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It is indicated that human follicular dermal papillae contain KATP channels that can respond to minoxidil and that tolbu tamide may suppress hair growth clinically; novel drugs designed specifically f

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APA 7 Shorter, K., Farjo, N. P., Picksley, S. M., & Randall, V. A. (2008). Human hair follicles contain two forms of atp-sensitive potassium channels, only one of which is sensitive to minoxidil.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 22(6), 1725-36. https://doi.org/10.1096/fj.07-099424
Vancouver Shorter K, Farjo NP, Picksley SM, Randall VA. Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil. FASE. jour. : offi. publ. Fede. Amer. Soci. Expe. Biol.. 2008;22(6):1725-36. doi:10.1096/fj.07-099424
AMA 11 Shorter K, Farjo NP, Picksley SM, Randall VA. Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil. FASE. jour. : offi. publ. Fede. Amer. Soci. Expe. Biol.. 2008;22(6):1725-36. doi:10.1096/fj.07-099424
Chicago Shorter, K., Farjo, N. P., Picksley, S. M., and Randall, V. A.. 2008. "Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil." FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22 (6): 1725-36. https://doi.org/10.1096/fj.07-099424
MLA 9 Shorter, K., et al. "Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil." FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 22, no. 6, 2008, pp. 1725-36. doi:10.1096/fj.07-099424.
PMID 18258787 ↗
DOI 10.1096/fj.07-099424

🏷️ 키워드 / MeSH 📖 같은 키워드 OA만

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그래프 OA 노드: 8/8 (100%) · 참조 0편 · 후속 8편

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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반