Location of stem cells of human hair follicles by clonal analysis.
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클론 분석을 통한 인체 모낭 줄기세포의 위치 규명.
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TL;DR
The hair follicle, like the epidermis, contains keratinocytes with the expected property of stem cells: an extensive proliferative capacity permitting the generation of a large amount of epithelium.
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📑 인용한 논문 (6) ▾
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연도별 인용 (2012–2026) · 합계 146
OpenAlex 토픽 ·
Hair Growth and Disorders
Skin and Cellular Biology Research
Wound Healing and Treatments
Abstract 🌐 Abstract
We have examined the growth capacity of keratinocytes isolated from human scalp hair follicles. Like the keratinocytes of glabrous epidermis, most of the colony-forming cells are classified as holoclones or meroclones when analyzed in a clonal assay. Some of them have extensive growth potential, as they are able to undergo at least 130 doublings. Therefore, the hair follicle, like the epidermis, contains keratinocytes with the expected property of stem cells: an extensive proliferative capacity permitting the generation of a large amount of epithelium. We have also examined the distribution of clonogenic keratinocytes within the hair follicle. Several hundred colony-forming cells are concentrated at a region below the midpoint of the follicle and outside the hair bulb. This region lies deeper than the site of insertion of the arrector pili muscle, which corresponds with the position of the bulge when the latter can be identified. In contrast, few colony-forming cells are present in the hair bulb, where most of the mitotic activity is observed during the active growth phase of the follicle. Paraclones, which are present both in the midregion and in the bulb of hair follicles, are unlikely to be the transient amplifying cells expected from kinetic studies.
The hair follicle, like the epidermis, contains keratinocytes with the expected property of stem cells: an extensive proliferative capacity permitting the generation of a large amount of epithelium.
APA 7
Rochat, A., Kobayashi, K., & Barrandon, Y. (1994). Location of stem cells of human hair follicles by clonal analysis.. Cell, 76(6), 1063-73. https://doi.org/10.1016/0092-8674(94)90383-2
Vancouver
Rochat A, Kobayashi K, Barrandon Y. Location of stem cells of human hair follicles by clonal analysis. Cell. 1994;76(6):1063-73. doi:10.1016/0092-8674(94)90383-2
AMA 11
Rochat A, Kobayashi K, Barrandon Y. Location of stem cells of human hair follicles by clonal analysis. Cell. 1994;76(6):1063-73. doi:10.1016/0092-8674(94)90383-2
Chicago
Rochat, A., Kobayashi, K., and Barrandon, Y.. 1994. "Location of stem cells of human hair follicles by clonal analysis." Cell 76 (6): 1063-73. https://doi.org/10.1016/0092-8674(94)90383-2
MLA 9
Rochat, A., et al. "Location of stem cells of human hair follicles by clonal analysis." Cell, vol. 76, no. 6, 1994, pp. 1063-73. doi:10.1016/0092-8674(94)90383-2.
PMID
8137423 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🤖 이 논문을 인용한 AI 인사이트 · 4건
🧮 메타후보
🏷 기초·실험
모낭 줄기세포 — 전임상 단계
P: 모낭 줄기세포 연구의 전임상 동물모델(특히 Nude 마우스 등 다양한 마우스 strain) 및 인체 PSC organoid 등 종(species O: 모낭 재생률, 이식 생착률 등 표준화된 정량적 효율 지표(stem cell marker 발현, 모낭 형성률 포함).
🧮 메타후보
🏷 기초·실험
모낭 줄기세포 — 메타분석 시기상조
P: 누드 마우스 xenograft 전임상 모델 및 모낭 줄기세포 관련 in vivo/organoid 연구 대상. 임상 결론을 위한 human int O: 줄기세포 마커 발현, 분화 계통, 모낭 형태형성, 모낭 재생률, graft 생착률.
🧮 메타후보
🏷 기초·실험
모낭 줄기세포 — 메타분석 시기상조
P: 전임상 모델 — 모낭 줄기세포를 다룬 human/mouse 연구(in vivo 계통추적, 클론분석, organoid, knock-in 모델 등) O: 줄기세포 마커·기능 지표(colony-forming efficiency, 계통 기여율) 및 hair regeneration rate 등 hair
🧮 메타후보
🏷 기초·실험
모낭 줄기세포 — 메타분석 시기상조
P: 전임상 모델 — 모낭 줄기세포를 다루는 동물(누드 마우스 등 종 다양) 및 세포/organoid 연구 대상. O: 표준화된 정량 지표 — 모낭 신생 개수, 줄기세포 표지자 양성 colony-forming efficiency, organoid 모낭 형성률.
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· 참조 0편 · 후속 8편
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