Essential role for Sonic hedgehog during hair follicle morphogenesis.
💡 한 문장 핵심
모낭 형태형성 과정에서 Sonic hedgehog의 필수적 역할.
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TL;DR
An obligatory role for the secreted morphogen Sonic hedgehog (Shh) during hair follicle development is reported, where it is required for normal advancement beyond the hair germ stage of development.
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📑 인용한 논문 (6) ▾
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연도별 인용 (2012–2026) · 합계 210
OpenAlex 토픽 ·
Hedgehog Signaling Pathway Studies
Hair Growth and Disorders
Cancer and Skin Lesions
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
모낭(hair follicle) 형태형성 과정에서 분비형 형태형성인자 Sonic hedgehog (Shh)의 역할을 규명하고자 함.
【방법】
Shh 결손(Shh -/-) 마우스 배아 피부와 대조군을 비교 분석하였고, 진동모(vibrissa) 외식편(explant)에 cyclopamine을 처리하여 Shh 신호전달을 차단한 후 모낭 분화 양상을 관찰함. Gli1과 Ptc1 발현을 통해 하위 신호전달을 평가함.
【주요 결과】
표피 placode와 진피 응축(dermal condensate)으로 구성된 모배아(hair germ)는 Shh -/-에서도 형성되었으나, 이후 단계로의 진행이 차단됨. Shh -/- 진피 응축에서 Gli1·Ptc1 발현이 감소하여 모유두(hair papilla)로 발전하지 못했지만, 후기 분화 표지자는 검출되어 Shh는 분화 자체가 아닌 형태형성 진행에 필수적임을 시사함.
【임상적 시사점 (성형외과 의사 관점)】
모발이식 후 모낭 재생 및 모발 재생 치료(탈모치료, 흉터 내 모낭 재형성) 개발 시 Shh 신호전달 활성화가 모유두 형성과 모낭 성숙의 핵심 표적이 될 수 있음. 반대로 기저세포암(BCC) 등 Shh 경로 활성화 종양 치료에 사용되는 vismodegib·cyclopamine 계열 억제제는 환자에서 탈모·모낭 위축 부작용을 유발할 수 있어 시술 전후 환자 상담 시 고려가 필요함.
The hair follicle is a source of epithelial stem cells and site of origin for several types of skin tumors. Although it is clear that follicles arise by way of a series of inductive tissue interactions, identification of the signaling molecules driving this process remains a major challenge in skin biology. In this study we report an obligatory role for the secreted morphogen Sonic hedgehog (Shh) during hair follicle development. Hair germs comprising epidermal placodes and associated dermal condensates were detected in both control and Shh -/- embryos, but progression through subsequent stages of follicle development was blocked in mutant skin. The expression of Gli1 and Ptc1 was reduced in Shh -/- dermal condensates and they failed to evolve into hair follicle papillae, suggesting that the adjacent mesenchyme is a critical target for placode-derived Shh. Despite the profound inhibition of hair follicle morphogenesis, late-stage follicle differentiation markers were detected in Shh -/- skin grafts, as well as cultured vibrissa explants treated with cyclopamine to block Shh signaling. Our findings reveal an essential role for Shh during hair follicle morphogenesis, where it is required for normal advancement beyond the hair germ stage of development.
【연구 목적】 모낭(hair follicle) 형태형성 과정에서 분비형 형태형성인자 Sonic hedgehog (Shh)의 역할을 규명하고자 함.
APA 7
Chiang, C., Swan, R. Z., Grachtchouk, M., Bolinger, M., Litingtung, Y., Robertson, E. K., Cooper, M. K., Gaffield, W., Westphal, H., Beachy, P. A., & Dlugosz, A. A. (1999). Essential role for sonic hedgehog during hair follicle morphogenesis.. Developmental biology, 205(1), 1-9. https://doi.org/10.1006/dbio.1998.9103
Vancouver
Chiang C, Swan RZ, Grachtchouk M, Bolinger M, Litingtung Y, Robertson EK, et al. Essential role for Sonic hedgehog during hair follicle morphogenesis. Developmental biology. 1999;205(1):1-9. doi:10.1006/dbio.1998.9103
AMA 11
Chiang C, Swan RZ, Grachtchouk M, Bolinger M, Litingtung Y, Robertson EK, et al. Essential role for Sonic hedgehog during hair follicle morphogenesis. Developmental biology. 1999;205(1):1-9. doi:10.1006/dbio.1998.9103
Chicago
Chiang, C., Swan, R. Z., Grachtchouk, M., Bolinger, M., Litingtung, Y., Robertson, E. K., Cooper, M. K., Gaffield, W., Westphal, H., Beachy, P. A., and .... 1999. "Essential role for Sonic hedgehog during hair follicle morphogenesis." Developmental biology 205 (1): 1-9. https://doi.org/10.1006/dbio.1998.9103
MLA 9
Chiang, C., et al. "Essential role for Sonic hedgehog during hair follicle morphogenesis." Developmental biology, vol. 205, no. 1, 1999, pp. 1-9. doi:10.1006/dbio.1998.9103.
PMID
9882493 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
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