Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle.
💡 한 문장 핵심
모낭의 중간엽 구성요소 발달에서 PDGF-A와 sonic hedgehog의 역할.
4/5 보강
TL;DR
It is shown that sonic hedgehog (shh)-/- mouse embryos have disrupted formation of dermal papillae, and expression patterns and mutant phenotypes suggest that epidermal PDGF-A has a role in stimulating the proliferation ofDermal mesenchymal cells that may contribute to the formation of Dermal papilla, mesenchylal sheaths and dermal fibroblasts.
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📑 인용한 논문 (6) ▾
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연도별 인용 (2012–2026) · 합계 123
OpenAlex 토픽 ·
Hair Growth and Disorders
Cancer and Skin Lesions
Skin and Cellular Biology Research
Abstract 🌐 Abstract
Skin appendages, such as hair, develop as a result of complex reciprocal signaling between epithelial and mesenchymal cells. These interactions are not well understood at the molecular level. Platelet-derived growth factor-A (PDGF-A) is expressed in the developing epidermis and hair follicle epithelium, and its receptor PDGF-Ralpha is expressed in associated mesenchymal structures. Here we have characterized the skin and hair phenotypes of mice carrying a null mutation in the PDGF-A gene. Postnatal PDGF-A-/- mice developed thinner dermis, misshapen hair follicles, smaller dermal papillae, abnormal dermal sheaths and thinner hair, compared with wild-type siblings. BrdU labeling showed reduced cell proliferation in the dermis and in the dermal sheaths of PDGF-A-/- skin. PDGF-A-/- skin transplantation to nude mice led to abnormal hair formation, reproducing some of the features of the skin phenotype of PDGF-A-/- mice. Taken together, expression patterns and mutant phenotypes suggest that epidermal PDGF-A has a role in stimulating the proliferation of dermal mesenchymal cells that may contribute to the formation of dermal papillae, mesenchymal sheaths and dermal fibroblasts. Finally, we show that sonic hedgehog (shh)-/- mouse embryos have disrupted formation of dermal papillae. Such embryos fail to form pre-papilla aggregates of postmitotic PDGF-Ralpha-positive cells, suggesting that shh has a critical role in the assembly of the dermal papilla.
It is shown that sonic hedgehog (shh)-/- mouse embryos have disrupted formation of dermal papillae, and expression patterns and mutant phenotypes suggest that epidermal PDGF-A has a role in stimulatin
APA 7
Karlsson, L., Bondjers, C., & Betsholtz, C. (1999). Roles for pdgf-a and sonic hedgehog in development of mesenchymal components of the hair follicle.. Development (Cambridge, England), 126(12), 2611-21. https://doi.org/10.1242/dev.126.12.2611
Vancouver
Karlsson L, Bondjers C, Betsholtz C. Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. Deve. (Cam. Engl.. 1999;126(12):2611-21. doi:10.1242/dev.126.12.2611
AMA 11
Karlsson L, Bondjers C, Betsholtz C. Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. Deve. (Cam. Engl.. 1999;126(12):2611-21. doi:10.1242/dev.126.12.2611
Chicago
Karlsson, L., Bondjers, C., and Betsholtz, C.. 1999. "Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle." Development (Cambridge, England) 126 (12): 2611-21. https://doi.org/10.1242/dev.126.12.2611
MLA 9
Karlsson, L., et al. "Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle." Development (Cambridge, England), vol. 126, no. 12, 1999, pp. 2611-21. doi:10.1242/dev.126.12.2611.
PMID
10331973 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Actins
- Animals
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Protein 4
- Bone Morphogenetic Proteins
- Cell Division
- Dermis
- Embryonic Induction
- Gene Expression Regulation
- Developmental
- Hair Follicle
- Hedgehog Proteins
- Male
- Membrane Proteins
- Mesoderm
- Mice
- Inbred BALB C
- Inbred Strains
- Mutant Strains
- Nude
- Muscle
- Smooth
- Patched Receptors
- Platelet-Derived Growth Factor
… 외 9개
🤖 이 논문을 인용한 AI 인사이트 · 4건
🧮 메타후보
🏷 기초·실험
BALB/c 마우스 — 통합 불가
P: MeSH 'Mice, Inbred BALB C' 단일 태그로 묶인 BALB/c 근교계 마우스 모델. 단일 질환·표현형으로 좁혀지지 않은 이질적 O: 결과변수가 통일되지 않음(정보부족). 종양 부피, 생존, 모낭 재생률 등 이질적 outcome이 혼재합니다.
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🏷 기초·실험
BALB/c 마우스 — 통합 불가
P: BALB/c 근교계 마우스를 사용한 전임상 연구이나, 서로 다른 질환·기전 모델이 혼재되어 단일 집단으로 특정되지 않습니다. O: 공통 종말점이 없으며, 적절히 재정의할 경우 예시로 동일 종양 모델에서의 종양 부피 억제율 등이 해당될 수 있습니다.
🧮 메타후보
🏷 기초·실험
BALB/c 마우스 — 메타분석 불가
P: BALB/c 근교계 마우스를 이용한 전임상 in vivo 종양·질환 모델 (예: 4T1 동소이식 BALB/c 유방암 모델). O: 공통 결과지표가 없음 — 종양 부피·생존 등이 제안되나 연구 간 결과변수가 무관하며, SR/MA 설계 시 SMD 또는 ratio of means
🧮 메타후보
🏷 기초·실험
BALB/c 마우스 — 메타분석 불가
P: BALB/c 근교계 마우스를 이용한 전임상 동물실험 집단으로, 특히 4T1 종양 마우스 등 동일 질환 모델로 좁혀야 메타분석 후보가 됩니다. 현 O: 연구 간 동일 정량 지표가 없어 통합 불가하며, 재정의 시 종양 부피 억제율 등 동일 정량적 결과지표(군별 n, 평균±SD, 추적 기간)를 공유
이 논문은 위 AI 빅데이터 분석에 인용된 근거 논문입니다.
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
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