RETRACTED: Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors.
4/5 보강
TL;DR
Inhibition of cyclin-dependent kinase 2 (CDK2) represents a potentially useful approach for the prevention of CIA in cancer patients by arresting the cell cycle and reducing the sensitivity of the epithelium to many cell cycle-active antitumor agents.
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
Topical application of these compounds in a neonatal rat model of CIA reduced hair loss at the site of application in 33 to 50% of the animals.
I · Intervention 중재 / 시술
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C · Comparison 대조 / 비교
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O · Outcome 결과 / 결론
Topical application of these compounds in a neonatal rat model of CIA reduced hair loss at the site of application in 33 to 50% of the animals. Thus, inhibition of CDK2 represents a potentially useful approach for the prevention of CIA in cancer patients.
📑 코퍼스 인용 관계
· 인용됨 2
📑 인용한 논문 (2) ▾
- Prevention and Treatment of Chemotherapy-Induced Alopecia. Dermatology practical & conceptual · 2020
- CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia. EMBO molecular medicine · 2019
연도별 인용 (2012–2025) · 합계 55
OpenAlex 토픽 ·
Cancer-related Molecular Pathways
Hair Growth and Disorders
Retinoids in leukemia and cellular processes
Abstract 🌐 Abstract
Most traditional cytotoxic anticancer agents ablate the rapidly dividing epithelium of the hair follicle and induce alopecia (hair loss). Inhibition of cyclin-dependent kinase 2 (CDK2), a positive regulator of eukaryotic cell cycle progression, may represent a therapeutic strategy for prevention of chemotherapy-induced alopecia (CIA) by arresting the cell cycle and reducing the sensitivity of the epithelium to many cell cycle-active antitumor agents. Potent small-molecule inhibitors of CDK2 were developed using structure-based methods. Topical application of these compounds in a neonatal rat model of CIA reduced hair loss at the site of application in 33 to 50% of the animals. Thus, inhibition of CDK2 represents a potentially useful approach for the prevention of CIA in cancer patients.
Inhibition of cyclin-dependent kinase 2 (CDK2) represents a potentially useful approach for the prevention of CIA in cancer patients by arresting the cell cycle and reducing the sensitivity of the epi
APA 7
Davis, S. T., Benson, B. G., Bramson, H. N., Chapman, D. E., Dickerson, S. H., Dold, K. M., Eberwein, D. J., Edelstein, M., Frye, S. V., Gampe, R. T., Griffin, R. J., Harris, P. A., Hassell, A. M., Holmes, W. D., Hunter, R. N., Knick, V. B., Lackey, K., Lovejoy, B., Luzzio, M. J., Murray, D., & ... (2001). Retracted: Prevention of chemotherapy-induced alopecia in rats by cdk inhibitors.. Science (New York, N.Y.), 291(5501), 134-7. https://doi.org/10.1126/science.291.5501.134
Vancouver
Davis ST, Benson BG, Bramson HN, Chapman DE, Dickerson SH, Dold KM, et al. RETRACTED: Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors. Science (New York, N.Y.). 2001;291(5501):134-7. doi:10.1126/science.291.5501.134
AMA 11
Davis ST, Benson BG, Bramson HN, Chapman DE, Dickerson SH, Dold KM, et al. RETRACTED: Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors. Science (New York, N.Y.). 2001;291(5501):134-7. doi:10.1126/science.291.5501.134
Chicago
Davis, S. T., Benson, B. G., Bramson, H. N., Chapman, D. E., Dickerson, S. H., Dold, K. M., Eberwein, D. J., Edelstein, M., Frye, S. V., Gampe, R. T., and .... 2001. "RETRACTED: Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors." Science (New York, N.Y.) 291 (5501): 134-7. https://doi.org/10.1126/science.291.5501.134
MLA 9
Davis, S. T., et al. "RETRACTED: Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors." Science (New York, N.Y.), vol. 291, no. 5501, 2001, pp. 134-7. doi:10.1126/science.291.5501.134.
PMID
11141566 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Alopecia
- Animals
- Newborn
- Antineoplastic Agents
- Antineoplastic Combined Chemotherapy Protocols
- Apoptosis
- CDC2-CDC28 Kinases
- Cell Cycle
- Cell Line
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinases
- Cyclophosphamide
- Cytoprotection
- DNA
- Doxorubicin
- Drug Design
- Enzyme Inhibitors
- Epithelium
- Etoposide
- Hair Follicle
- Humans
- Indoles
- Mice
- SCID
… 외 8개
인용 관계
그래프 OA 노드: 2/2 (100%)
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