Plasticity of hair follicle dermal cells in wound healing and induction.
💡 한 문장 핵심
창상 치유와 모낭 유도에서 모낭 진피세포의 가소성
4/5 보강
TL;DR
The capacity of adult hair follicle dermal cells to participate in new follicle induction and regeneration, and to elicit responses from diverse epithelial partners, demonstrates a level of developmental promiscuity and influence far exceeding that of interfollicular fibroblasts.
📑 코퍼스 인용 관계
· 인용됨 11
📑 인용한 논문 (6) ▾
- [Hair transplantation in wound healing and scar repair in special areas]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025
- Maintaining Inducibility of Dermal Follicle Cells on Silk Fibroin/Sodium Alginate Scaffold… Biology · 2021
- The dermal sheath: An emerging component of the hair follicle stem cell niche. Experimental dermatology · 2021
- Culture and Differentiation of Human Hair Follicle Dermal Papilla Cells in a Soft 3D Self-… Biomolecules · 2020
- Follicular Unit Grafting in Chronic Nonhealing Leg Ulcers: A Clinical Study. Journal of cutaneous and aesthetic surgery · 2017
- Epidermal stem cells and skin tissue engineering in hair follicle regeneration. World journal of stem cells · 2015
연도별 인용 (2012–2025) · 합계 105
OpenAlex 토픽 ·
Hair Growth and Disorders
Wound Healing and Treatments
Dermatologic Treatments and Research
Abstract 🌐 Abstract
The capacity of adult hair follicle dermal cells to participate in new follicle induction and regeneration, and to elicit responses from diverse epithelial partners, demonstrates a level of developmental promiscuity and influence far exceeding that of interfollicular fibroblasts. We have recently suggested that adult follicle dermal cells have extensive stem or progenitor cell activities, including an important role in skin dermal wound healing. Given that up to now tissue engineered skin equivalents have several deficiencies, including the absence of hair follicles, we investigated the capacity of follicle dermal cells to be incorporated into skin wounds; to form hair follicles in wound environments; and to create a hair follicle-derived skin equivalent. In our study, we implanted rat follicle dermal cells labelled with a vital dye into ear and body skin wounds. We found that they were incorporated into the new dermis in a manner similar to skin fibroblasts, but that lower follicle dermal sheath also assimilated into hair follicles. Using different combinations of follicle dermal cells and outer root sheath epithelial cells in punch biopsy wounds, we showed that new hair follicles were formed only with the inclusion of intact dermal papillae. Finally by combining follicle dermal sheath and outer root sheath cells in organotypic chambers, we created a skin equivalent with characteristic dermal and epidermal architecture and a normal basement membrane - the first skin to be produced entirely from hair follicle cells. These data support the hypothesis that follicle dermal cells may be important in wound healing and demonstrate their potential usefulness in human skin equivalents and skin substitutes. While we have made progress towards producing skin equivalents that contain follicles, we suggest that the failure of cultured dermal papilla cells to induce follicle formation in wounds illustrates the complex role the follicle dermis may play in skin. We believe that it demonstrates a genuine dichotomy of activity for follicle cells within skin.
The capacity of adult hair follicle dermal cells to participate in new follicle induction and regeneration, and to elicit responses from diverse epithelial partners, demonstrates a level of developmen
APA 7
Gharzi, A., Reynolds, A. J., & Jahoda, C. A. (2003). Plasticity of hair follicle dermal cells in wound healing and induction.. Experimental dermatology, 12(2), 126-36. https://doi.org/10.1034/j.1600-0625.2003.00106.x
Vancouver
Gharzi A, Reynolds AJ, Jahoda CA. Plasticity of hair follicle dermal cells in wound healing and induction. Experimental dermatology. 2003;12(2):126-36. doi:10.1034/j.1600-0625.2003.00106.x
AMA 11
Gharzi A, Reynolds AJ, Jahoda CA. Plasticity of hair follicle dermal cells in wound healing and induction. Experimental dermatology. 2003;12(2):126-36. doi:10.1034/j.1600-0625.2003.00106.x
Chicago
Gharzi, A., Reynolds, A. J., and Jahoda, C. A.. 2003. "Plasticity of hair follicle dermal cells in wound healing and induction." Experimental dermatology 12 (2): 126-36. https://doi.org/10.1034/j.1600-0625.2003.00106.x
MLA 9
Gharzi, A., et al. "Plasticity of hair follicle dermal cells in wound healing and induction." Experimental dermatology, vol. 12, no. 2, 2003, pp. 126-36. doi:10.1034/j.1600-0625.2003.00106.x.
PMID
12702140 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 11
- SKPs derive from hair follicle precursors and exhibit properties of adult dermal stem cells.
- Epidermal stem cells and skin tissue engineering in hair follicle regeneration.
- Dissociated human dermal papilla cells induce hair follicle neogenesis in grafted dermal-epidermal c…
- Dermal papilla cells improve the wound healing process and generate hair bud-like structures in graf…
- The dermal sheath: An emerging component of the hair follicle stem cell niche.
- Culture and Differentiation of Human Hair Follicle Dermal Papilla Cells in a Soft 3D Self-Assembling…
- Bioengineering the hair follicle.
- Maintaining Inducibility of Dermal Follicle Cells on Silk Fibroin/Sodium Alginate Scaffold for Enhan…
- Follicular Unit Grafting in Chronic Nonhealing Leg Ulcers: A Clinical Study.
- From hair to cornea: toward the therapeutic use of hair follicle-derived stem cells in the treatment…
- [Hair transplantation in wound healing and scar repair in special areas].