Plasticity of hair follicle dermal cells in wound healing and induction.
💡 한 문장 핵심
창상 치유와 모낭 유도에서 모낭 진피세포의 가소성
5/5 보강
TL;DR
The capacity of adult hair follicle dermal cells to participate in new follicle induction and regeneration, and to elicit responses from diverse epithelial partners, demonstrates a level of developmental promiscuity and influence far exceeding that of interfollicular fibroblasts.
📑 코퍼스 인용 관계
· 인용됨 11
📑 인용한 논문 (6) ▾
- [Hair transplantation in wound healing and scar repair in special areas]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025
- Maintaining Inducibility of Dermal Follicle Cells on Silk Fibroin/Sodium Alginate Scaffold… Biology · 2021
- The dermal sheath: An emerging component of the hair follicle stem cell niche. Experimental dermatology · 2021
- Culture and Differentiation of Human Hair Follicle Dermal Papilla Cells in a Soft 3D Self-… Biomolecules · 2020
- Follicular Unit Grafting in Chronic Nonhealing Leg Ulcers: A Clinical Study. Journal of cutaneous and aesthetic surgery · 2017
- Epidermal stem cells and skin tissue engineering in hair follicle regeneration. World journal of stem cells · 2015
연도별 인용 (2012–2025) · 합계 105
OpenAlex 토픽 ·
Hair Growth and Disorders
Wound Healing and Treatments
Dermatologic Treatments and Research
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
조직공학 인공피부(skin equivalent)의 한계인 모낭(hair follicle) 부재 문제를 해결하기 위해, 성숙한 모낭 진피세포(follicle dermal cells)가 창상 치유에 참여하고 새 모낭을 유도하는 능력을 가지는지, 나아가 모낭세포만으로 인공피부를 만들 수 있는지 확인하고자 하였다.
【방법】
생체염색약(vital dye)으로 표지한 쥐의 모낭 진피세포를 귀·몸통 피부 창상에 이식하고, 펀치 생검(punch biopsy) 창상에서 모낭 진피세포와 외모근초(outer root sheath, ORS) 상피세포를 다양하게 조합하였다. 또한 모낭 진피초(dermal sheath)와 ORS 세포를 organotypic chamber에서 배양해 인공피부 형성을 시도하였다.
【주요 결과】
이식된 모낭 진피세포는 일반 피부 섬유아세포처럼 새 진피에 통합되었고, 하부 진피초는 모낭 구조에도 동화되었다. 새 모낭은 온전한 모유두(dermal papilla)가 포함된 경우에만 형성되었으며(배양된 모유두 세포 단독으로는 유도 실패), 모낭세포만으로 정상 진피·표피 구조와 기저막(basement membrane)을 갖춘 인공피부를 최초로 제작하였다.
【임상적 시사점 (성형외과 의사 관점)】
모낭 진피세포는 단순 섬유아세포보다 강력한 줄기/전구세포 활성을 지녀, 창상 치유 촉진과 모낭을 포함한 차세대 인공피부·피부대체물(skin substitute) 개발의 핵심 자원이 될 수 있다. 다만 신선한 온전 모유두가 필수적이고 배양 세포는 유도능을 잃는다는 점은, 향후 탈모 치료 및 화상·재건 영역에서의 임상 적용 시 세포 처리 방식 설계에 중요한 제약으로 고려해야 한다.
The capacity of adult hair follicle dermal cells to participate in new follicle induction and regeneration, and to elicit responses from diverse epithelial partners, demonstrates a level of developmental promiscuity and influence far exceeding that of interfollicular fibroblasts. We have recently suggested that adult follicle dermal cells have extensive stem or progenitor cell activities, including an important role in skin dermal wound healing. Given that up to now tissue engineered skin equivalents have several deficiencies, including the absence of hair follicles, we investigated the capacity of follicle dermal cells to be incorporated into skin wounds; to form hair follicles in wound environments; and to create a hair follicle-derived skin equivalent. In our study, we implanted rat follicle dermal cells labelled with a vital dye into ear and body skin wounds. We found that they were incorporated into the new dermis in a manner similar to skin fibroblasts, but that lower follicle dermal sheath also assimilated into hair follicles. Using different combinations of follicle dermal cells and outer root sheath epithelial cells in punch biopsy wounds, we showed that new hair follicles were formed only with the inclusion of intact dermal papillae. Finally by combining follicle dermal sheath and outer root sheath cells in organotypic chambers, we created a skin equivalent with characteristic dermal and epidermal architecture and a normal basement membrane - the first skin to be produced entirely from hair follicle cells. These data support the hypothesis that follicle dermal cells may be important in wound healing and demonstrate their potential usefulness in human skin equivalents and skin substitutes. While we have made progress towards producing skin equivalents that contain follicles, we suggest that the failure of cultured dermal papilla cells to induce follicle formation in wounds illustrates the complex role the follicle dermis may play in skin. We believe that it demonstrates a genuine dichotomy of activity for follicle cells within skin.
【연구 목적】 조직공학 인공피부(skin equivalent)의 한계인 모낭(hair follicle) 부재 문제를 해결하기 위해, 성숙한 모낭 진피세포(follicle dermal cells)가 창상 치유에 참여하고 새 모낭을 유도하는 능력을 가지는지, 나아가 모낭세포만으로 인공피부를 만들 수 있는지 확인하고자 하였다.
APA 7
Gharzi, A., Reynolds, A. J., & Jahoda, C. A. (2003). Plasticity of hair follicle dermal cells in wound healing and induction.. Experimental dermatology, 12(2), 126-36. https://doi.org/10.1034/j.1600-0625.2003.00106.x
Vancouver
Gharzi A, Reynolds AJ, Jahoda CA. Plasticity of hair follicle dermal cells in wound healing and induction. Experimental dermatology. 2003;12(2):126-36. doi:10.1034/j.1600-0625.2003.00106.x
AMA 11
Gharzi A, Reynolds AJ, Jahoda CA. Plasticity of hair follicle dermal cells in wound healing and induction. Experimental dermatology. 2003;12(2):126-36. doi:10.1034/j.1600-0625.2003.00106.x
Chicago
Gharzi, A., Reynolds, A. J., and Jahoda, C. A.. 2003. "Plasticity of hair follicle dermal cells in wound healing and induction." Experimental dermatology 12 (2): 126-36. https://doi.org/10.1034/j.1600-0625.2003.00106.x
MLA 9
Gharzi, A., et al. "Plasticity of hair follicle dermal cells in wound healing and induction." Experimental dermatology, vol. 12, no. 2, 2003, pp. 126-36. doi:10.1034/j.1600-0625.2003.00106.x.
PMID
12702140 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
· 참조 0편 · 후속 8편
이 논문을 인용한 후속 연구 11
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- Bioengineering the hair follicle.
- Maintaining Inducibility of Dermal Follicle Cells on Silk Fibroin/Sodium Alginate Scaffold for Enhan…
- Follicular Unit Grafting in Chronic Nonhealing Leg Ulcers: A Clinical Study.
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- [Hair transplantation in wound healing and scar repair in special areas].