Cultured peribulbar dermal sheath cells can induce hair follicle development and contribute to the dermal sheath and dermal papilla.
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TL;DR
The results indicate transplanted DP and DSC cells were equally capable of DP formation and hair follicle induction, and suggests the DP and peribulbar DSC may be functionally similar.
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연도별 인용 (2012–2026) · 합계 184
OpenAlex 토픽 ·
Hair Growth and Disorders
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
모낭(hair follicle) 재생 능력이 있는 진피유두(dermal papilla, DP) 세포와 모구주위 진피초 컵(peribulbar dermal sheath cup, DSC) 세포의 모낭 유도 능력과 기능적 유사성을 비교 검증하고자 함.
【방법】
GFP(녹색형광단백질) 발현 및 비형질전환 마우스 수염 모낭에서 DP, DSC, 비구부 진피초 세포를 각각 배양하여 마우스 귀와 발바닥에 이식한 후, 공초점현미경(confocal microscopy)으로 신생 모낭 형성과 세포 기여도를 추적하고 알칼리성 인산분해효소(alkaline phosphatase, ALP) 활성을 측정.
【주요 결과】
DP 세포와 DSC 세포 모두 귀·발바닥 양쪽에서 새로운 모낭을 유도하였으나, 비구부 진피초 세포는 유도 능력이 없었음. 이식된 GFP 세포만으로 구성된 진피유두 또는 숙주 세포와 혼합된 진피유두가 관찰되었으며, DSC는 낮은 ALP 활성, DP는 높은 ALP 활성을 보여 ALP가 모낭 유도능 세포의 간편한 표지자로 활용 가능함.
【임상적 시사점 (성형외과 의사 관점)】
탈모 치료 및 모발이식(hair transplantation) 영역에서 모유두뿐 아니라 모구주위 진피초 컵 세포도 모낭 신생(neogenesis)의 세포 공급원으로 활용될 수 있어, 공여부가 제한된 환자에서 세포 기반 모낭 재생 치료의 가능성을 시사함. 향후 자가 세포 배양 이식술 개발 시 ALP 활성 측정이 유도 능력을 가진 세포 선별의 간편한 품질관리 지표로 사용될 수 있음.
Green fluorescent protein (GFP)-expressing wild-type, and nontransgenic mouse vibrissa follicle cells were cultured and implanted to mouse ears and footpads. Dermal papiller (DP)-derived cells and cells from the peribulbar dermal sheath "cup" (DSC) induced new hair follicles in both implanted ears and footpads, while nonbulbar dermal sheath cells did not. Confocal microscopy revealed that GFP-expressing DP and DSC cells induced hair growth associated with the formation of DP exclusively comprised of fluorescent cells. In mouse ears, but not footpads, fluorescent DP and DSC cells could also be identified in DP along with nonfluorescent cells. DSC cells were characterized in vivo and in vitro by low alkaline phosphatase activity in contrast to high alkaline phosphatase in DP cells. The results indicate transplanted DP and DSC cells were equally capable of DP formation and hair follicle induction. This suggests the DP and peribulbar DSC may be functionally similar. In addition to observing papillae exclusively composed of GFP-expressing cells, DP and DSC cells may also have combined with resident cells to form papillae composed of implanted GFP-expressing cells and host-derived non-GFP-expressing cells. Alkaline phosphatase expression may be utilized as a simple marker to identify hair follicle mesenchyme derived cells with hair follicle inductive abilities.
【연구 목적】 모낭(hair follicle) 재생 능력이 있는 진피유두(dermal papilla, DP) 세포와 모구주위 진피초 컵(peribulbar dermal sheath cup, DSC) 세포의 모낭 유도 능력과 기능적 유사성을 비교 검증하고자 함.
APA 7
McElwee, K. J., Kissling, S., Wenzel, E., Huth, A., & Hoffmann, R. (2003). Cultured peribulbar dermal sheath cells can induce hair follicle development and contribute to the dermal sheath and dermal papilla.. The Journal of investigative dermatology, 121(6), 1267-75. https://doi.org/10.1111/j.1523-1747.2003.12568.x
Vancouver
McElwee KJ, Kissling S, Wenzel E, Huth A, Hoffmann R. Cultured peribulbar dermal sheath cells can induce hair follicle development and contribute to the dermal sheath and dermal papilla. Jour. inve. derm.. 2003;121(6):1267-75. doi:10.1111/j.1523-1747.2003.12568.x
AMA 11
McElwee KJ, Kissling S, Wenzel E, Huth A, Hoffmann R. Cultured peribulbar dermal sheath cells can induce hair follicle development and contribute to the dermal sheath and dermal papilla. Jour. inve. derm.. 2003;121(6):1267-75. doi:10.1111/j.1523-1747.2003.12568.x
Chicago
McElwee, K. J., Kissling, S., Wenzel, E., Huth, A., and Hoffmann, R.. 2003. "Cultured peribulbar dermal sheath cells can induce hair follicle development and contribute to the dermal sheath and dermal papilla." The Journal of investigative dermatology 121 (6): 1267-75. https://doi.org/10.1111/j.1523-1747.2003.12568.x
MLA 9
McElwee, K. J., et al. "Cultured peribulbar dermal sheath cells can induce hair follicle development and contribute to the dermal sheath and dermal papilla." The Journal of investigative dermatology, vol. 121, no. 6, 2003, pp. 1267-75. doi:10.1111/j.1523-1747.2003.12568.x.
PMID
14675169 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 8/8 (100%)
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