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Wnt signaling, lgr5, and stem cells in the intestine and skin.

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장과 피부에서의 Wnt 신호전달, Lgr5 및 줄기세포.

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4/5 보강
The American journal of pathology 📖 저널 OA 75.7% 2021: 1/1 OA 2022: 2/3 OA 2023: 2/6 OA 2024: 5/9 OA 2025: 14/19 OA 2026: 22/33 OA 2021~2026 2009 Vol.174(3) p. 715-21 피인용 4회 참고 50건 cited 380 OA RCR 6.05 Hair Growth and Disorders
TL;DR A comprehensive overview of the stem cell compartments in the intestine and skin with a focus on the cycling, yet long-lived and multipotent, Lgr5(+ve) stem cell populations is provided.
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PubMed DOI PMC OpenAlex Semantic 마지막 보강 2026-05-09
📑 코퍼스 인용 관계 · 인용됨 4 · 인용함 50
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연도별 인용 (2012–2026) · 합계 277
OpenAlex 토픽 · Hair Growth and Disorders Wnt/β-catenin signaling in development and cancer Cancer Cells and Metastasis

Haegebarth A, Clevers H

📖 무료 전문 🟢 PMC 전문 PMC2665733 🔓 OA PDF oa
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Abstract

Stem cells hold great promise for regenerative medicine, but have remained elusive in many tissues because of a lack of adequate definitive markers. Progress in mouse genetics has provided the tools for characterization and validation of stem cell markers by functional and/or lineage tracing assays. The Wnt target gene Lgr5 has been recently identified as a novel stem cell marker of the intestinal epithelium and the hair follicle. In the intestine, Lgr5 is exclusively expressed in cycling crypt base columnar cells. Genetic lineage-tracing experiments revealed that crypt base columnar cells are capable of self-renewal and multipotency, thus representing genuine intestinal stem cells. In the stem cell niche of the murine hair follicle, Lgr5 is expressed in actively cycling cells. Transplantation and lineage tracing experiments have demonstrated that these Lgr5(+ve) cells maintain all cell lineages of the hair follicle throughout long periods of time and can build entire new hair follicles. Expression of Lgr5 in multiple other organs indicates that it may represent a global marker of adult stem cells. This review attempts to provide a comprehensive overview of the stem cell compartments in the intestine and skin with a focus on the cycling, yet long-lived and multipotent, Lgr5(+ve) stem cell populations.
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A comprehensive overview of the stem cell compartments in the intestine and skin with a focus on the cycling, yet long-lived and multipotent, Lgr5(+ve) stem cell populations is provided.

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↓ .bib ↓ .ris
APA 7 Haegebarth, A., & Clevers, H. (2009). Wnt signaling, lgr5, and stem cells in the intestine and skin.. The American journal of pathology, 174(3), 715-21. https://doi.org/10.2353/ajpath.2009.080758
Vancouver Haegebarth A, Clevers H. Wnt signaling, lgr5, and stem cells in the intestine and skin. Amer. jour. path.. 2009;174(3):715-21. doi:10.2353/ajpath.2009.080758
AMA 11 Haegebarth A, Clevers H. Wnt signaling, lgr5, and stem cells in the intestine and skin. Amer. jour. path.. 2009;174(3):715-21. doi:10.2353/ajpath.2009.080758
Chicago Haegebarth, A., and Clevers, H.. 2009. "Wnt signaling, lgr5, and stem cells in the intestine and skin." The American journal of pathology 174 (3): 715-21. https://doi.org/10.2353/ajpath.2009.080758
MLA 9 Haegebarth, A., and Clevers H. "Wnt signaling, lgr5, and stem cells in the intestine and skin." The American journal of pathology, vol. 174, no. 3, 2009, pp. 715-21. doi:10.2353/ajpath.2009.080758.
PMID 19197002 ↗
DOI 10.2353/ajpath.2009.080758

🏷️ 키워드 / MeSH 📖 같은 키워드 OA만

인용 관계

그래프 OA 노드: 4/5 (80%) · 참조 1편 · 후속 3편

이 논문이 참조한 문헌 31

외부 PMID 30건 (DB 미수집)

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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반

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