Noninvasive Shock Wave Treatment for Capsular Contractures After Breast Augmentation: A Rabbit Study.
Abstract
[BACKGROUND] Capsular contracture is the most common complication of breast augmentation. Although numerous procedures are intended to prevent capsular contracture, their efficacy does not satisfy surgeons or patients. In the present study, we used shock waves to develop innovative protocols to treat capsular contracture in rabbits.
[METHODS] We used shock waves to treat capsular contracture in a rabbit model. Six clinical parameters were evaluated to determine the treatment efficacy of shock waves on the pathological histology of capsular contracture. Dual-flip-angle T1-mapping magnetic resonance imaging was used to confirm the pathological findings.
[RESULTS] Among the parameters, myxoid change, vascular proliferation, and lymphoplasma cell infiltration around the capsule increased more after treatment than they did in a control group. Capsular thickness, inner thinner collagen layer, and capsule wall collagen deposition decreased after shock wave treatment; only the inner thinner collagen layer and capsule wall collagen deposition changed significantly. The MRI findings for both scar thickness and water content were consistent with pathological biology findings.
[CONCLUSION] This was the first pilot study and trial to treat capsular contractures using shock waves. We found that shock waves can cause changes in the structure or the composition of capsular contracture. We conclude that the treatment could decrease water content, loosen structure, decrease collagen deposition, and might alleviate scar formation from capsular contracture. We believe that the treatment could be a viable remedy for capsular contractures.
[NO LEVEL ASSIGNED] This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
[METHODS] We used shock waves to treat capsular contracture in a rabbit model. Six clinical parameters were evaluated to determine the treatment efficacy of shock waves on the pathological histology of capsular contracture. Dual-flip-angle T1-mapping magnetic resonance imaging was used to confirm the pathological findings.
[RESULTS] Among the parameters, myxoid change, vascular proliferation, and lymphoplasma cell infiltration around the capsule increased more after treatment than they did in a control group. Capsular thickness, inner thinner collagen layer, and capsule wall collagen deposition decreased after shock wave treatment; only the inner thinner collagen layer and capsule wall collagen deposition changed significantly. The MRI findings for both scar thickness and water content were consistent with pathological biology findings.
[CONCLUSION] This was the first pilot study and trial to treat capsular contractures using shock waves. We found that shock waves can cause changes in the structure or the composition of capsular contracture. We conclude that the treatment could decrease water content, loosen structure, decrease collagen deposition, and might alleviate scar formation from capsular contracture. We believe that the treatment could be a viable remedy for capsular contractures.
[NO LEVEL ASSIGNED] This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 합병증 | capsular contracture
|
피막구축 | dict | 7 | |
| 시술 | breast augmentation
|
유방성형술 | dict | 2 | |
| 해부 | breast
|
유방 | dict | 2 | |
| 해부 | lymphoplasma cell
|
scispacy | 1 | ||
| 해부 | capsule wall collagen
|
scispacy | 1 | ||
| 해부 | capsular contractures
|
scispacy | 1 | ||
| 해부 | capsular
|
scispacy | 1 | ||
| 합병증 | scar
|
scispacy | 1 | ||
| 약물 | [BACKGROUND] Capsular
|
scispacy | 1 | ||
| 약물 | [NO
|
scispacy | 1 | ||
| 질환 | Shock
|
C0036974
Shock
|
scispacy | 1 | |
| 질환 | Capsular Contractures
|
C1707264
Capsular Contracture
|
scispacy | 1 | |
| 질환 | capsule
|
scispacy | 1 | ||
| 기타 | Wave
|
scispacy | 1 | ||
| 기타 | Capsular
|
scispacy | 1 | ||
| 기타 | patients
|
scispacy | 1 | ||
| 기타 | rabbits
|
scispacy | 1 | ||
| 기타 | rabbit
|
scispacy | 1 | ||
| 기타 | vascular
|
scispacy | 1 | ||
| 기타 | collagen
|
scispacy | 1 | ||
| 기타 | capsule wall collagen
|
scispacy | 1 | ||
| 기타 | capsular contractures
|
scispacy | 1 |
MeSH Terms
Animals; Biopsy, Needle; Breast Implants; Disease Models, Animal; Female; High-Energy Shock Waves; Image Processing, Computer-Assisted; Immunohistochemistry; Implant Capsular Contracture; Magnetic Resonance Imaging; Mammaplasty; Mammary Glands, Animal; Pilot Projects; Rabbits; Random Allocation; Reference Values; Sensitivity and Specificity
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