Histopathology of alopecia: a clinicopathological approach to diagnosis.
💡 한 문장 핵심
탈모의 조직병리학: 진단을 위한 임상병리학적 접근.
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TL;DR
The histopathology of alopecia should be considered as a clinicopathological approach to diagnosis, rather than a clinical basis for diagnosis, Stefanato says.
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📑 인용한 논문 (6) ▾
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연도별 인용 (2012–2026) · 합계 223
OpenAlex 토픽 ·
Hair Growth and Disorders
Autoimmune Bullous Skin Diseases
Dermatologic Treatments and Research
🇰🇷 한글 요약 🌐 Abstract
【연구 목적】
원발성 반흔성(scarring) 및 비반흔성(non-scarring) 탈모의 조직병리학적 진단 접근법을 임상-병리 통합 관점에서 정리하고, 진단 정확도를 높이기 위한 핵심 요소를 제시한다.
【방법】
주요 반흔성 탈모(림프구성: 원판상 홍반루푸스(DLE), 모공편평태선(lichen planopilaris, LPP), 중심원심성 반흔성 탈모(CCCA), 브로크 가성탈모(pseudopelade of Brocq) / 호중구성: 박멸성 모낭염(folliculitis decalvans), 박리성 모낭염(dissecting folliculitis) / 혼합형: 켈로이드성 여드름(acne keloidalis))와 비반흔성 탈모(남성형 탈모(androgenic alopecia), 휴지기 탈모(telogen effluvium), 원형 탈모(alopecia areata), 발모벽(trichotillomania), 견인성 탈모(traction alopecia))에 대한 조직학적 소견을 종설 형식으로 검토하였다.
【주요 결과】
충분한 조직 채취(adequate tissue sampling)와 적절한 검사실 처리(가로/세로 절편 등)가 진단의 핵심이며, 임상 정보(병력, 탈모 양상)와 결합되지 않으면 조직 소견만으로는 감별이 어렵다. 반흔성 탈모는 염증 세포 종류(림프구성/호중구성/혼합형)에 따라 분류되며, 비반흔성 탈모는 모낭 단위 보존 여부와 성장기/휴지기 비율(anagen/telogen ratio)이 진단 단서가 된다.
【임상적 시사점 (성형외과 의사 관점)】
모발이식(hair transplantation) 후보 환자에서 반흔성 탈모를 놓치면 이식 모낭 생존율이 급격히 떨어지므로, 두피 발적·인설·모공 소실 등 활동성 염증 징후가 있을 경우 반드시 4mm 펀치 생검(가로 절편 포함)을 의뢰해야 한다. 특히 CCCA, LPP는 초기에 남성형 탈모와 혼동되기 쉬워, 의심 시 조직학적 확진과 염증 안정화(최소 1년) 이후 이식을 고려하는 것이 안전하다.
Interpretation of the histopathological findings of primary scarring and non-scarring alopecias may prove daunting. This is especially true if the biopsy specimen is inadequate, and the clinical history and pattern of the alopecia are not known. Common forms of scarring alopecias discussed here are the lymphocytic (discoid lupus erythematosus, lichen planopilaris, central centrifugal cicatricial alopecia, pseudopelade of Brocq), the neutrophilic (folliculitis decalvans, dissecting folliculitis), and the mixed (acne keloidalis) entities. The non-scarring alopecias reviewed are androgenic alopecia, telogen effluvium, alopecia areata, trichotillomania and traction alopecia. In all cases of primary alopecia, adequate tissue sampling and appropriate laboratory processing, in combination with pertinent clinical information, provide the key to diagnosis.
【연구 목적】 원발성 반흔성(scarring) 및 비반흔성(non-scarring) 탈모의 조직병리학적 진단 접근법을 임상-병리 통합 관점에서 정리하고, 진단 정확도를 높이기 위한 핵심 요소를 제시한다.
APA 7
Stefanato, C. M. (2010). Histopathology of alopecia: A clinicopathological approach to diagnosis.. Histopathology, 56(1), 24-38. https://doi.org/10.1111/j.1365-2559.2009.03439.x
Vancouver
Stefanato CM. Histopathology of alopecia: a clinicopathological approach to diagnosis. Histopathology. 2010;56(1):24-38. doi:10.1111/j.1365-2559.2009.03439.x
AMA 11
Stefanato CM. Histopathology of alopecia: a clinicopathological approach to diagnosis. Histopathology. 2010;56(1):24-38. doi:10.1111/j.1365-2559.2009.03439.x
Chicago
Stefanato, C. M.. 2010. "Histopathology of alopecia: a clinicopathological approach to diagnosis." Histopathology 56 (1): 24-38. https://doi.org/10.1111/j.1365-2559.2009.03439.x
MLA 9
Stefanato, C. M.. "Histopathology of alopecia: a clinicopathological approach to diagnosis." Histopathology, vol. 56, no. 1, 2010, pp. 24-38. doi:10.1111/j.1365-2559.2009.03439.x.
PMID
20055903 ↗
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
인용 관계
그래프 OA 노드: 7/8 (88%)
· 참조 0편 · 후속 7편
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