Combination of Adipose-Derived Stromal/Stem Cells and Decellularized Adipose Tissue Hydrogel for Osteogenic Applications.
Abstract
Adipose-derived stromal/stem cells (ASCs) and decellularized adipose tissue (DAT) are adipose tissue products obtained from individuals undergoing fat removal procedures like liposuction, lipectomy, or breast reduction. DAT hydrogel is prepared by removing the cells from the adipose tissue and digesting it to form a liquid material that forms a gel at physiological temperature. ASCs seeded on DAT have displayed osteogenic potential in vitro and in animal models of bone defects. Herein, we describe the methods for preparing DAT hydrogel, ASC seeding in DAT hydrogel, osteogenic differentiation of ASCs, creation of critical-sized femur defect model in mice, its treatment with ASC-DAT hydrogel, and analyses.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 시술 | breast reduction
|
유방성형술 | dict | 1 | |
| 시술 | liposuction
|
지방흡입 | dict | 1 | |
| 해부 | Adipose-Derived Stromal/Stem Cells
|
scispacy | 1 | ||
| 해부 | Adipose Tissue
|
scispacy | 1 | ||
| 해부 | ASCs
→ Adipose-derived stromal/stem cells
|
scispacy | 1 | ||
| 해부 | DAT
→ decellularized adipose tissue
|
scispacy | 1 | ||
| 해부 | fat
|
scispacy | 1 | ||
| 해부 | cells
|
scispacy | 1 | ||
| 해부 | bone
|
scispacy | 1 | ||
| 해부 | ASC
|
scispacy | 1 | ||
| 해부 | femur
|
scispacy | 1 | ||
| 해부 | breast
|
유방 | dict | 1 | |
| 질환 | bone defects
|
C5436370
Bone defects
|
scispacy | 1 | |
| 질환 | critical-sized femur defect
|
scispacy | 1 | ||
| 기타 | mice
|
scispacy | 1 |
MeSH Terms
Animals; Mice; Osteogenesis; Hydrogels; Adipose Tissue; Adipocytes; Cell Differentiation; Stem Cells
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