Effects of long-term proton pump inhibitor use on sexual hormones and sexual and reproductive health in female patients.
4/5 보강
TL;DR
It is suggested that long-term PPI use may cause endocrine hormone disturbances leading to sexual difficulties in women.
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
101 participants, patients with sexual complaints have significantly altered levels of prolactin (p = 0.
I · Intervention 중재 / 시술
little attention
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Serum values of Sex hormone binding globulin SHBG (p < 0.001), estradiol (p = 0.002) and total testosterone (p < 0.001) were significantly altered between normal prolactin and hyperprolactinemic patients. [CONCLUSION] These findings suggest that long-term PPI use may cause endocrine hormone disturbances leading to sexual difficulties in women.
연도별 인용 (2024–2025) · 합계 2
OpenAlex 토픽 ·
Gastroesophageal reflux and treatments
Helicobacter pylori-related gastroenterology studies
Neuroendocrine Tumor Research Advances
【연구 목적】 프로톤 펌프 억제제(PPI)의 장기 사용이 여성의 생식 호르몬 및 생식 건강에 미치는 영향을 평가하여, 단기 치료에서는 안전성이 입증되었으나 장기 사용에 대한 안전성 데이터가 부족한 부분을 규명하고자 하였다.
- p-value p = 0.05
- p-value p < 0.001
- 연구 설계 cross-sectional
APA
Muhammad Ashfaq, Qasim Raza Khan, et al. (2024). Effects of long-term proton pump inhibitor use on sexual hormones and sexual and reproductive health in female patients.. Endocrine, 83(2), 494-501. https://doi.org/10.1007/s12020-023-03572-8
MLA
Muhammad Ashfaq, et al.. "Effects of long-term proton pump inhibitor use on sexual hormones and sexual and reproductive health in female patients.." Endocrine, vol. 83, no. 2, 2024, pp. 494-501.
PMID
37914918 ↗
Abstract 한글 요약
[PURPOSE] Proton pump inhibitors (PPIs) are widely used to treat a range of gastrointestinal diseases around the world. Long-term use of PPIs has been associated to a variety of undesirable effects. Although short-term therapy has been shown to have little or no effect on endocrine hormone in women, however, its long-term safety has received little attention. We aimed at evaluating long-term use of PPIs and its effects on female reproductive hormones as well as related clinical consequences.
[METHODS] A cross-sectional study was conducted in two outpatient gastroenterology clinics in the province of Khyber Pakhtunkhwa. This study included female patients who had been using PPIs on a regular basis for 3 months or more.
[RESULTS] In total of 101 participants, patients with sexual complaints have significantly altered levels of prolactin (p = 0.05), estrogen (p < 0.001) and progesterone (p = 0.001) than patient without sexual complaints. The frequency of amenorrhea (p < 0.001), cyclic disturbances (p < 0.001), breast augmentation (p = 0.001) and painful breast (p = 0.004) were statistically significant in patients with raised serum prolactin values. Serum values of Sex hormone binding globulin SHBG (p < 0.001), estradiol (p = 0.002) and total testosterone (p < 0.001) were significantly altered between normal prolactin and hyperprolactinemic patients.
[CONCLUSION] These findings suggest that long-term PPI use may cause endocrine hormone disturbances leading to sexual difficulties in women.
[METHODS] A cross-sectional study was conducted in two outpatient gastroenterology clinics in the province of Khyber Pakhtunkhwa. This study included female patients who had been using PPIs on a regular basis for 3 months or more.
[RESULTS] In total of 101 participants, patients with sexual complaints have significantly altered levels of prolactin (p = 0.05), estrogen (p < 0.001) and progesterone (p = 0.001) than patient without sexual complaints. The frequency of amenorrhea (p < 0.001), cyclic disturbances (p < 0.001), breast augmentation (p = 0.001) and painful breast (p = 0.004) were statistically significant in patients with raised serum prolactin values. Serum values of Sex hormone binding globulin SHBG (p < 0.001), estradiol (p = 0.002) and total testosterone (p < 0.001) were significantly altered between normal prolactin and hyperprolactinemic patients.
[CONCLUSION] These findings suggest that long-term PPI use may cause endocrine hormone disturbances leading to sexual difficulties in women.
【연구 목적】
프로톤 펌프 억제제(PPI)의 장기 사용이 여성의 생식 호르몬 및 생식 건강에 미치는 영향을 평가하여, 단기 치료에서는 안전성이 입증되었으나 장기 사용에 대한 안전성 데이터가 부족한 부분을 규명하고자 하였다.
【방법】
파키스탄의 두 외래 위장병 클리닉에서 PPI를 3개월 이상 규칙적으로 복용한 여성 환자 101명을 대상으로 횡단면 연구(cross-sectional study)를 수행하였다. 성 호르몬 수치와 성기능, 생식기 관련 임상 증상을 비교 분석하였다.
【주요 결과】
성적 불만이 있는 환자군에서 프로락틴(prolactin), 에스트로겐(estrogen), 프로게스테론(progesterone) 수치가 비해당 군에 비해 유의하게 변화하였다. 고프로락틴혈증(hyperprolactinemia)이 있는 환자에서는 무월경(amenorrhea), 주기적 장애, 유방 비대(breast augmentation), 유방 통증의 빈도가 통계적으로 유의하게 높았으며, 성호르몬 결합 글로불린(SHBG), 에스트라디올(estradiol), 총 테스토스테론(total testosterone) 수치도 정상 프로락틴 군과 유의한 차이를 보였다.
【임상적 시사점 (성형외과 의사 관점)】
성형외과, 특히 유방 재건술(breast reconstruction)이나 유방 성형술(mammoplasty)을 계획하는 여성 환자에서 장기 위장약 복용력을 반드시 확인해야 한다. PPI 장기 사용으로 인한 고프로락틴혈증은 유방 비대 및 유방 통증을 유발할 수 있어, 수술 전 유방 조직의 병리적 상태 평가에 영향을 줄 수 있다. 또한 호르몬 불균형은 수술 후 상처 치유(wound healing)와 조직 재생에 간접적인 영향을 미칠 가능성이 있으므로, 수술 전 전신 상태 평가 시 내분비 계통의 이상 유무를 고려해야 한다. 환자 상담 시 위장관 질환 관리와 성형 수술 간의 약물 상호작용 및 호르몬적 영향을 설명하여 기대치 조정이 필요하다. 다학제 협진(multidisciplinary team) 관점에서 위장병학과와 협력하여 장기 약물 복용 환자의 호르몬 모니터링이 필요할 수 있다.
추출된 의학 개체 (NER)
시술
유방성형술
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | breast
|
유방 | dict | 2 | |
| 시술 | breast augmentation
|
유방성형술 | dict | 1 | |
| 해부 | serum prolactin
|
scispacy | 1 | ||
| 해부 | Serum
|
scispacy | 1 | ||
| 약물 | estrogen
|
C0014939
estrogens
|
scispacy | 1 | |
| 약물 | progesterone
|
C0033308
progesterone
|
scispacy | 1 | |
| 약물 | globulin SHBG
|
scispacy | 1 | ||
| 약물 | estradiol
|
C0014912
estradiol
|
scispacy | 1 | |
| 약물 | testosterone
|
C0039601
testosterone
|
scispacy | 1 | |
| 약물 | [PURPOSE] Proton pump inhibitors
|
scispacy | 1 | ||
| 약물 | PPIs
→ pump inhibitors
|
scispacy | 1 | ||
| 약물 | prolactin
|
scispacy | 1 | ||
| 질환 | gastrointestinal diseases
|
C0017178
Gastrointestinal Diseases
|
scispacy | 1 | |
| 질환 | sexual complaints
|
scispacy | 1 | ||
| 질환 | amenorrhea
|
C0002453
Amenorrhea
|
scispacy | 1 | |
| 질환 | cyclic disturbances
|
scispacy | 1 | ||
| 질환 | painful breast
|
C0024902
Mastodynia
|
scispacy | 1 | |
| 질환 | hyperprolactinemic
|
C0020514
Hyperprolactinemia
|
scispacy | 1 | |
| 질환 | endocrine hormone disturbances
|
scispacy | 1 | ||
| 질환 | PPIs
→ pump inhibitors
|
scispacy | 1 | ||
| 기타 | endocrine hormone
|
scispacy | 1 | ||
| 기타 | women
|
scispacy | 1 | ||
| 기타 | Sex hormone
|
scispacy | 1 | ||
| 기타 | globulin SHBG
|
scispacy | 1 | ||
| 기타 | prolactin
|
scispacy | 1 |
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