A comparative study between central quadrantectomy and nipple resection with areola preservation Versus Grisotti flap mammoplasty in central breast lesions extending to nipple: a randomized clinical trial.
기술보고
4/5 보강
TL;DR
The safety and ease of central quadrantectomy and nipple resection with areola preservation were demonstrated in a two-year follow-up, with a lower incidence of complications compared to the Grisotti flap mammoplasty technique.
OpenAlex 토픽 ·
Breast Implant and Reconstruction
Breast Cancer Treatment Studies
Reconstructive Surgery and Microvascular Techniques
【연구 목적】 유두까지 침범한 중앙부 유방 악성 종양 치료에서 새로운 재건성 유방종양학술술인 유두 절제 및 유륜 보존 하 중앙 사분절 절제술(CQ-NR-AP)과 그리소티 유방성형술(GFM)을 비교하기 위함이다.
- p-value p = 0.001
APA
Philobater Bahgat Adly Awad, Basma Hussein Abdelaziz Hassan, et al. (2025). A comparative study between central quadrantectomy and nipple resection with areola preservation Versus Grisotti flap mammoplasty in central breast lesions extending to nipple: a randomized clinical trial.. Journal of the Egyptian National Cancer Institute, 37(1), 3. https://doi.org/10.1186/s43046-024-00253-z
MLA
Philobater Bahgat Adly Awad, et al.. "A comparative study between central quadrantectomy and nipple resection with areola preservation Versus Grisotti flap mammoplasty in central breast lesions extending to nipple: a randomized clinical trial.." Journal of the Egyptian National Cancer Institute, vol. 37, no. 1, 2025, pp. 3.
PMID
39828867 ↗
Abstract 한글 요약
[OBJECTIVES] To evaluate central quadrantectomy and nipple resection with areola preservation (CQ-NR-AP) as a new reconstructive oncoplastic technique Versus Grisotti flap mammoplasty (GFM) in central malignant tumors of the breast extending to the nipple, in terms of time procedures, breast symmetry, patient satisfaction, postoperative complications, and local recurrence.
[PATIENTS AND METHODS] The current study is a single-blind, single-center, randomized, controlled trial that was performed between May 2018 and May 2023 in the breast surgery unit of University Hospitals. This trial involved 40 individuals who had central breast lesions that extended to the nipple and were monitored for two years following surgery.
[RESULTS] As regards the mean intra-operative time in minutes, in the group (I) was 80.1 with a standard deviation of ± 13.9, and ingroup (II) was 138.9 with a standard deviation of ± 14.02 (p = 0.001). The seroma was detected in zero cases in group (I) and 2(10%) cases in group II (p = 0.487) and those two cases were managed by aspiration only. Regarding, the wound infection was found in one case (5%) in group (I) and 3(15%) cases in group II (p = 0.605). Regarding patient satisfaction and breast, symmetry was much better in the group (I).
[CONCLUSION] The safety and ease of central quadrantectomy and nipple resection with areola preservation were demonstrated in a two-year follow-up, with a lower incidence of complications compared to the Grisotti flap mammoplasty technique. Furthermore, this approach was associated with higher patient satisfaction, which is a significant achievement in the management of centrally located breast tumors.
[TRIAL REGISTRATION] PACTR202405688323721. 28/05/2024.
[PATIENTS AND METHODS] The current study is a single-blind, single-center, randomized, controlled trial that was performed between May 2018 and May 2023 in the breast surgery unit of University Hospitals. This trial involved 40 individuals who had central breast lesions that extended to the nipple and were monitored for two years following surgery.
[RESULTS] As regards the mean intra-operative time in minutes, in the group (I) was 80.1 with a standard deviation of ± 13.9, and ingroup (II) was 138.9 with a standard deviation of ± 14.02 (p = 0.001). The seroma was detected in zero cases in group (I) and 2(10%) cases in group II (p = 0.487) and those two cases were managed by aspiration only. Regarding, the wound infection was found in one case (5%) in group (I) and 3(15%) cases in group II (p = 0.605). Regarding patient satisfaction and breast, symmetry was much better in the group (I).
[CONCLUSION] The safety and ease of central quadrantectomy and nipple resection with areola preservation were demonstrated in a two-year follow-up, with a lower incidence of complications compared to the Grisotti flap mammoplasty technique. Furthermore, this approach was associated with higher patient satisfaction, which is a significant achievement in the management of centrally located breast tumors.
[TRIAL REGISTRATION] PACTR202405688323721. 28/05/2024.
【연구 목적】
유두까지 침범한 중앙부 유방 악성 종양 치료에서 새로운 재건성 유방종양학술술인 유두 절제 및 유륜 보존 하 중앙 사분절 절제술(CQ-NR-AP)과 그리소티 유방성형술(GFM)을 비교하기 위함이다. 두 기법 간의 수술 시간, 유방 대칭성, 환자 만족도, 사후 합병증 및 국소 재발률을 평가하여 임상적 우위를 규명하는 것이 핵심 목표이다.
【방법】
2018년 5월부터 2023년 5월까지 단일 센터에서 수행된 단일 맹검 무작위 대조 시험으로, 유두까지 침범한 중앙부 유방 병변이 있는 40명의 환자를 대상으로 하였다. 환자들은 두 군으로 무작위 배정되었으며, 수술 후 2년간 추적 관찰을 통해 수술 시간, 혈종 및 감염 발생률, 유방 대칭성 및 환자 만족도를 정량적·정성적으로 분석하였다.
【주요 결과】
중앙 사분절 절제 및 유두 절제·유륜 보존 군(CQ-NR-AP)의 평균 수술 시간이 80.1분으로 그리소티 유방성형술(GFM)군의 138.9분보다 유의하게 짧았다(p=0.001). 혈종은 CQ-NR-AP군에서 0건, GFM군에서 2건(10%) 발생했으며, 상처 감염은 각각 1건(5%), 3건(15%)으로 두 군 간 통계적 유의차는 없었으나(p=0.605) CQ-NR-AP군에서 더 낮은 경향을 보였다. 환자 만족도와 유방 대칭성은 CQ-NR-AP군에서 더 우수하게 나타났다.
【임상적 시사점 (성형외과 의사 관점)】
성형외과 의사는 유두-유륜 복합체(NAC)를 보존해야 하는 중앙부 유방 절제술 후 재건 시, 그리소티 유방성형술보다 수술 시간이 절반 가까이 단축되는 CQ-NR-AP 기법을 고려할 수 있다. 특히 유방 조직의 혈류 공급에 민감한 재건 수술에서 혈종 발생률을 낮추고 수술 효율성을 높일 수 있어, 다학제 협진 팀 내 유방외과와의 공조 시 수술 계획 수립에 유용한 데이터가 된다. 환자 만족도와 유방 대칭성 측면에서 우수한 결과를 보였으므로, 미용적 결과에 대한 기대가 높은 환자 상담 시 새로운 옵션으로 제시할 수 있다. 그러나 이 연구가 단일 센터의 소규모 표본을 대상으로 했으므로, 광범위한 임상 적용 전에는 다기관 연구를 통한 검증이 필요함을 인지해야 한다. 성형외과적 관점에서 유두의 혈관 공급을 해치지 않으면서도 절제 공백을 최소화하는 이 기법은 유방 재건술의 술전 평가 및 시술 선택에 중요한 참고 자료가 된다.
추출된 의학 개체 (NER)
기타
유륜 areola
전체 NER 표 보기
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 해부 | breast
|
유방 | dict | 7 | |
| 시술 | mammoplasty
|
유방성형술 | dict | 3 | |
| 시술 | flap
|
피판재건술 | dict | 3 | |
| 해부 | nipple
|
유두 | scispacy | 1 | |
| 합병증 | flap mammoplasty
|
scispacy | 1 | ||
| 합병증 | nipple
|
유두 | scispacy | 1 | |
| 합병증 | wound
|
상처 | scispacy | 1 | |
| 합병증 | seroma
|
장액종 | dict | 1 | |
| 합병증 | wound infection
|
감염 | dict | 1 | |
| 약물 | CQ-NR-AP
→ central quadrantectomy and nipple resection with areola preservation
|
scispacy | 1 | ||
| 질환 | breast lesions
|
C0567489
Lesion of breast
|
scispacy | 1 | |
| 질환 | central malignant tumors
|
scispacy | 1 | ||
| 질환 | infection
|
감염 |
C0009450
Communicable Diseases
|
scispacy | 1 |
| 질환 | breast tumors
|
C1458155
Mammary Neoplasms
|
scispacy | 1 | |
| 질환 | nipple
|
유두 | scispacy | 1 | |
| 기타 | areola
|
유륜 | scispacy | 1 |
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Female
- Breast Neoplasms
- Nipples
- Mammaplasty
- Adult
- Middle Aged
- Surgical Flaps
- Patient Satisfaction
- Single-Blind Method
- Postoperative Complications
- Mastectomy
- Segmental
- Treatment Outcome
- Neoplasm Recurrence
- Local
- Breast cancer
- Central breast tumors
- Grisotti flap
- Grisotti technique
- Mammoplasty
- Oncoplastic breast surgery
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