The effect of oxygen reserve index guided oxygen titration on oxidative stress in rhinoplasty surgery: a randomized controlled trial.
TL;DR
It is concluded that ORi guided oxygen titration may reduce the severity of hyperoxia and may decrease oxidative stress in rhinoplasty surgery.
OpenAlex 토픽 ·
Nasal Surgery and Airway Studies
Sinusitis and nasal conditions
Airway Management and Intubation Techniques
【연구 목적】 비강성형술(rhinoplasty) 환자에서 산소 예비 지수(Oxygen Reserve Index, ORi) 기반의 산소 농도 조절이 과산소증(hyperoxia)을 예방하고, 이로 인한 산화 스트레스(oxidative stress)를 감소시킬 수 있는지 평가하는 것이 본 연구의 핵심 목표이다.
APA
Recep Karakaşoğlu, Fatih Doğu Geyik, et al. (2025). The effect of oxygen reserve index guided oxygen titration on oxidative stress in rhinoplasty surgery: a randomized controlled trial.. BMC anesthesiology, 25(1), 542. https://doi.org/10.1186/s12871-025-03424-0
MLA
Recep Karakaşoğlu, et al.. "The effect of oxygen reserve index guided oxygen titration on oxidative stress in rhinoplasty surgery: a randomized controlled trial.." BMC anesthesiology, vol. 25, no. 1, 2025, pp. 542.
PMID
41188744
Abstract
[BACKGROUND] The aim of this study is to evaluate whether the use of Oxygen Reserve Index (ORi) can prevent hyperoxia in patients undergoing rhinoplasty surgery and whether it can reduce oxidative stress caused by hyperoxia.
[METHODS] A total of 60 patients, who were scheduled for rhinoplasty surgery and had an American Society of Anesthesiologists (ASA) score of I and II, were included in the study. The patients were randomly divided into two groups: the ORi group (Group R) and the control group (Group C). In Group R, oxygen support was titrated to keep the ORi values close to zero. In the control group, oxygen support was provided conventionally. Arterial blood gas samples were taken after intubation, at the 120th minute of the surgery and at the end of the surgery to record partial arterial oxygen pressure (PaO₂) values. During this process, patients' peripheral oxygen saturation (SpO₂) and ORi values were continuously recorded along with hemodynamic data. Preoperative and postoperative blood samples were collected from both groups, and oxidative stress was assessed by evaluating thiol-disulfide homeostasis and ischemia-modified albumin (IMA), which are current indicators of oxidative stress.
[RESULTS] The demographic characteristics and the surgical durations were similar between the groups. PaO₂ values were lower in Group R compared to Group C. ORi values were correlated with PaO₂ values. Preoperative native thiol, total thiol, and disulfide values were similar in both groups. In both groups, postoperative native thiol, total thiol, and disulfide values decreased compared to the preoperative period, while IMA values increased. In Group R, the decrease in native thiol and total thiol values and the increase in IMA values were less than in Group C.
[CONCLUSION] We concluded that ORi guided oxygen titration may reduce the severity of hyperoxia and may decrease oxidative stress in rhinoplasty surgery.
[TRIAL REGISTRATION] ClinicalTrials.gov Identifier NCT07158073. Registered on 21 August 2025.
[METHODS] A total of 60 patients, who were scheduled for rhinoplasty surgery and had an American Society of Anesthesiologists (ASA) score of I and II, were included in the study. The patients were randomly divided into two groups: the ORi group (Group R) and the control group (Group C). In Group R, oxygen support was titrated to keep the ORi values close to zero. In the control group, oxygen support was provided conventionally. Arterial blood gas samples were taken after intubation, at the 120th minute of the surgery and at the end of the surgery to record partial arterial oxygen pressure (PaO₂) values. During this process, patients' peripheral oxygen saturation (SpO₂) and ORi values were continuously recorded along with hemodynamic data. Preoperative and postoperative blood samples were collected from both groups, and oxidative stress was assessed by evaluating thiol-disulfide homeostasis and ischemia-modified albumin (IMA), which are current indicators of oxidative stress.
[RESULTS] The demographic characteristics and the surgical durations were similar between the groups. PaO₂ values were lower in Group R compared to Group C. ORi values were correlated with PaO₂ values. Preoperative native thiol, total thiol, and disulfide values were similar in both groups. In both groups, postoperative native thiol, total thiol, and disulfide values decreased compared to the preoperative period, while IMA values increased. In Group R, the decrease in native thiol and total thiol values and the increase in IMA values were less than in Group C.
[CONCLUSION] We concluded that ORi guided oxygen titration may reduce the severity of hyperoxia and may decrease oxidative stress in rhinoplasty surgery.
[TRIAL REGISTRATION] ClinicalTrials.gov Identifier NCT07158073. Registered on 21 August 2025.
추출된 의학 개체 (NER)
| 유형 | 영어 표현 | 한국어 / 풀이 | UMLS CUI | 출처 | 등장 |
|---|---|---|---|---|---|
| 시술 | rhinoplasty
|
코성형술 | dict | 4 | |
| 해부 | IMA
→ ischemia-modified albumin
|
scispacy | 1 | ||
| 약물 | oxygen
|
C0030054
oxygen
|
scispacy | 1 | |
| 약물 | hyperoxia
|
C0242706
Hyperoxia
|
scispacy | 1 | |
| 약물 | ASA
→ American Society of Anesthesiologists
|
C2346733
American Society of Anesthesiologists
|
scispacy | 1 | |
| 약물 | disulfide
|
C0012771
Disulfides
|
scispacy | 1 | |
| 약물 | peripheral oxygen
|
scispacy | 1 | ||
| 약물 | thiol-disulfide
|
scispacy | 1 | ||
| 약물 | ORi
→ Oxygen Reserve Index
|
scispacy | 1 | ||
| 기타 | ORi
→ Oxygen Reserve Index
|
scispacy | 1 | ||
| 기타 | Arterial blood gas samples
|
scispacy | 1 | ||
| 기타 | arterial
|
scispacy | 1 | ||
| 기타 | ischemia-modified albumin
|
scispacy | 1 |
MeSH Terms
Humans; Oxidative Stress; Male; Female; Rhinoplasty; Adult; Oxygen; Hyperoxia; Middle Aged; Oxygen Saturation; Young Adult; Blood Gas Analysis; Oxygen Inhalation Therapy; Serum Albumin, Human; Biomarkers
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