Role for long term treatment in NMOSD induced by the immune checkpoint inhibitor cemiplimab.
1/5 보강
We present the case of a 54-year-old patient treated with cemiplimab, an immune checkpoint inhibitor (ICI), for multiple basal cell carcinomas in the context of Gorlin Goltz syndrome.
APA
Oelbrandt F, Marignier R, Dubois B (2025). Role for long term treatment in NMOSD induced by the immune checkpoint inhibitor cemiplimab.. Clinical neurology and neurosurgery, 257, 109120. https://doi.org/10.1016/j.clineuro.2025.109120
MLA
Oelbrandt F, et al.. "Role for long term treatment in NMOSD induced by the immune checkpoint inhibitor cemiplimab.." Clinical neurology and neurosurgery, vol. 257, 2025, pp. 109120.
PMID
40914627 ↗
Abstract 한글 요약
We present the case of a 54-year-old patient treated with cemiplimab, an immune checkpoint inhibitor (ICI), for multiple basal cell carcinomas in the context of Gorlin Goltz syndrome. Gorlin Goltz syndrome is an autosomal dominant multisystem disorder characterized, among other features, by multiple early-onset basal cell carcinomas (BCCs). After receiving Cemiplimab, she developed aquaporin-4 antibody (AQP4-Ab) positive neuromyelitis optica spectrum disorder (NMOSD). While several case reports have documented NMOSD induced by other ICIs, this is the first case associated with cemiplimab. Although guidelines exist for the acute treatment of a first relapse of ICI-induced NMOSD, long-term management to prevent new relapses remains challenging. We believe that these patients require maintenance therapy to prevent future relapses and propose rituximab or tocilizumab as suitable options.
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