Delayed-Onset ICI-Associated Myocarditis: When Immunotherapy's Cardiac Consequences Outlast Treatment.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: prior ICI exposure and new cardiomyopathy
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[TAKE-HOME MESSAGES] ICI myocarditis should be considered in patients with prior ICI exposure and new cardiomyopathy. Multimodal imaging and biopsy are key to timely diagnosis and management.
[BACKGROUND] Immune checkpoint inhibitors (ICIs) are increasingly used in cancer therapy, but they may cause immune-related adverse events, including myocarditis, a rare but potentially fatal complica
APA
Adel FW, Saleh G, et al. (2025). Delayed-Onset ICI-Associated Myocarditis: When Immunotherapy's Cardiac Consequences Outlast Treatment.. JACC. Case reports, 30(30), 105307. https://doi.org/10.1016/j.jaccas.2025.105307
MLA
Adel FW, et al.. "Delayed-Onset ICI-Associated Myocarditis: When Immunotherapy's Cardiac Consequences Outlast Treatment.." JACC. Case reports, vol. 30, no. 30, 2025, pp. 105307.
PMID
41043911 ↗
Abstract 한글 요약
[BACKGROUND] Immune checkpoint inhibitors (ICIs) are increasingly used in cancer therapy, but they may cause immune-related adverse events, including myocarditis, a rare but potentially fatal complication.
[CASE SUMMARY] A 74-year-old man with lung adenocarcinoma treated with durvalumab presented with acute-on-chronic hypoxemic respiratory failure and hypotension. He was recently diagnosed with ICI pneumonitis and was taking corticosteroids. Evaluation revealed elevated troponins, new T-wave inversions, and reduced left ventricular ejection fraction. Coronary angiography showed no obstructive disease. Cardiac magnetic resonance revealed diffuse myocardial edema with nonischemic late gadolinium enhancement. Endomyocardial biopsy confirmed lymphohistiocytic infiltrates consistent with ICI myocarditis.
[DISCUSSION] ICI-associated myocarditis can mimic acute coronary syndrome or stress cardiomyopathy. Cardiac magnetic resonance and biopsy are essential for accurate diagnosis. Early recognition and initiation of high-dose corticosteroids are critical for improved outcomes.
[TAKE-HOME MESSAGES] ICI myocarditis should be considered in patients with prior ICI exposure and new cardiomyopathy. Multimodal imaging and biopsy are key to timely diagnosis and management.
[CASE SUMMARY] A 74-year-old man with lung adenocarcinoma treated with durvalumab presented with acute-on-chronic hypoxemic respiratory failure and hypotension. He was recently diagnosed with ICI pneumonitis and was taking corticosteroids. Evaluation revealed elevated troponins, new T-wave inversions, and reduced left ventricular ejection fraction. Coronary angiography showed no obstructive disease. Cardiac magnetic resonance revealed diffuse myocardial edema with nonischemic late gadolinium enhancement. Endomyocardial biopsy confirmed lymphohistiocytic infiltrates consistent with ICI myocarditis.
[DISCUSSION] ICI-associated myocarditis can mimic acute coronary syndrome or stress cardiomyopathy. Cardiac magnetic resonance and biopsy are essential for accurate diagnosis. Early recognition and initiation of high-dose corticosteroids are critical for improved outcomes.
[TAKE-HOME MESSAGES] ICI myocarditis should be considered in patients with prior ICI exposure and new cardiomyopathy. Multimodal imaging and biopsy are key to timely diagnosis and management.
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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