IL-1β Upregulates PD-L1 in Small Extracellular Vesicle of Endothelial Origin.
1/5 보강
Programmed death ligand 1(PD-L1) is of significant importance in the regulation of immune cells, and its levels increase in response to inflammation in HUVECs.
APA
Gagliardi MC, Felicetti F, et al. (2025). IL-1β Upregulates PD-L1 in Small Extracellular Vesicle of Endothelial Origin.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 39(22), e71272. https://doi.org/10.1096/fj.202502508R
MLA
Gagliardi MC, et al.. "IL-1β Upregulates PD-L1 in Small Extracellular Vesicle of Endothelial Origin.." FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 39, no. 22, 2025, pp. e71272.
PMID
41277383 ↗
Abstract 한글 요약
Programmed death ligand 1(PD-L1) is of significant importance in the regulation of immune cells, and its levels increase in response to inflammation in HUVECs. In this letter, we examined the expression of PD-L1 on small extracellular vesicles (sEVs) in human umbilical vein endothelial cells (HUVECs) and investigated its modulation in response to interleukin-1β (IL-1β), a key player in the immune response and is involved in the pathogenesis of several diseases. We found that stimulation of HUVECs with IL-1β resulted in the release of a higher number of sEVs-PD-L1positive. This result provides significant insights into the potential role of sEVs-PD-L1positive in regulating inflammatory and immune responses in the vascular endothelium.
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