CD8 T Cell Cytotoxicity and Exhaustion Underlie Liver Allograft Rejection: Insights From a Murine Transcriptomic Atlas.
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The gene expression uncovering the molecular mechanism of liver transplantation (LT) rejection and immune tolerance remains unclear.
APA
Jiang YZ, Zhou GP (2025). CD8 T Cell Cytotoxicity and Exhaustion Underlie Liver Allograft Rejection: Insights From a Murine Transcriptomic Atlas.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 39(22), e71259. https://doi.org/10.1096/fj.202503096R
MLA
Jiang YZ, et al.. "CD8 T Cell Cytotoxicity and Exhaustion Underlie Liver Allograft Rejection: Insights From a Murine Transcriptomic Atlas.." FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 39, no. 22, 2025, pp. e71259.
PMID
41284316 ↗
Abstract 한글 요약
The gene expression uncovering the molecular mechanism of liver transplantation (LT) rejection and immune tolerance remains unclear. The mice orthotopic LT rejection and tolerance models were established. Liver sections were obtained for transcriptome sequencing. A total of 2560 DEGs were identified in the rejection group. The major enrichment pathways included graft-versus-host disease, Th17 cell differentiation, T cell receptor signaling pathway and cytokine-cytokine receptor interaction. The screened top 10 hub genes, including Ctla4, Ifng, Gzmb, Pdcd1, cd28, cd8a, Tbx21, and Lag3, were associated with T cell cytotoxicity and exhaustion. The gene expression levels of functional characteristics of T cell exhaustion, including Il2ra, Tnf, and Ifng were all significantly decreased in the tolerance group. Flow cytometry confirmed the significantly higher expression of TIM-3 and PD-1 in CD8 T cells. Immunohistochemical staining of liver tissues also showed remarkably increased granzyme-B-positive cells in the rejection group. A comprehensive molecular profiling of the immune alterations was observed, especially the dynamic change of CD8 T cell-mediated cytotoxicity and exhaustion. This provides new insights into the molecular mechanism of LT rejection and immune tolerance.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Animals
- Graft Rejection
- Liver Transplantation
- Mice
- CD8-Positive T-Lymphocytes
- Transcriptome
- Inbred C57BL
- Inbred BALB C
- Male
- Allografts
- Liver
- Hepatitis A Virus Cellular Receptor 2
- Programmed Cell Death 1 Receptor
- Gene Expression Profiling
- CD8+ T cell‐mediated cytotoxicity
- exhaustion
- immune tolerance
- liver transplantation rejection
- transcriptomic analysis
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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