Molecular mechanisms and potential targeting strategies of ubiquitin‑proteasome system‑mediated PD‑1/PD‑L1 ubiquitination in tumor immune suppression (Review).
1/5 보강
Cancer cells play a pivotal role in immune evasion by activating the programmed cell death protein 1 (PD‑1)/PD‑ligand (L)1 signaling pathway or immune cells within the tumor microenvironment.
APA
Gu LH, Guo A, et al. (2025). Molecular mechanisms and potential targeting strategies of ubiquitin‑proteasome system‑mediated PD‑1/PD‑L1 ubiquitination in tumor immune suppression (Review).. Oncology reports, 54(6). https://doi.org/10.3892/or.2025.9000
MLA
Gu LH, et al.. "Molecular mechanisms and potential targeting strategies of ubiquitin‑proteasome system‑mediated PD‑1/PD‑L1 ubiquitination in tumor immune suppression (Review).." Oncology reports, vol. 54, no. 6, 2025.
PMID
41041864 ↗
Abstract 한글 요약
Cancer cells play a pivotal role in immune evasion by activating the programmed cell death protein 1 (PD‑1)/PD‑ligand (L)1 signaling pathway or immune cells within the tumor microenvironment. The ubiquitin‑proteasome system (UPS), the primary pathway for intracellular protein degradation, has been increasingly implicated in mediating tumor immune escape and resistance to anti‑PD‑1/PD‑L1 therapy. Targeting the UPS has demonstrated significant potential in improving the efficacy of tumor immunotherapy. Therefore, a deeper understanding of the molecular mechanisms by which UPS contributes to tumor resistance against PD‑1/PD‑L1 blockade, along with the optimization of UPS‑targeted small‑molecule drug design, holds scientific and clinical significance. In the present review, the role of UPS in tumor immune evasion through the regulation of PD‑1/PD‑L1 ubiquitination was discussed and potential therapeutic agents that may enhance the effectiveness of anti‑PD‑1/PD‑L1 treatment are summarized. These insights provide a theoretical foundation for advancing cancer immunotherapy and developing novel combination strategies.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- B7-H1 Antigen
- Ubiquitination
- Neoplasms
- Proteasome Endopeptidase Complex
- Ubiquitin
- Programmed Cell Death 1 Receptor
- Tumor Microenvironment
- Tumor Escape
- Immune Checkpoint Inhibitors
- Animals
- Signal Transduction
- Immunotherapy
- Drug Resistance
- Neoplasm
- cancer immunotherapy
- molecular mechanisms
- programmed cell death protein 1/programmed death‑ligand 1
- ubiquitin‑proteasome system
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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