Tumour-infiltrating immune cells in tonsillar cancer: no tissue-level signs of inflammageing in the elderly.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: HNSCC were sourced from the Cancer Genome Atlas (TCGA)
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSION AND SIGNIFICANCE] In the elderly, key immune cells are present in TC, and immune checkpoint molecules are overexpressed. This may be relevant to the stratification of patients for ICI.
[BACKGROUND] Age-related immunosenescence, also known as 'inflammageing', may impact the elderly's ability to mount immune responses against cancers and compromise the effectiveness of immune checkpoi
APA
Swoboda S, Vanagas R, et al. (2025). Tumour-infiltrating immune cells in tonsillar cancer: no tissue-level signs of inflammageing in the elderly.. Acta oto-laryngologica, 145(12), 1218-1227. https://doi.org/10.1080/00016489.2025.2575865
MLA
Swoboda S, et al.. "Tumour-infiltrating immune cells in tonsillar cancer: no tissue-level signs of inflammageing in the elderly.." Acta oto-laryngologica, vol. 145, no. 12, 2025, pp. 1218-1227.
PMID
41173228 ↗
Abstract 한글 요약
[BACKGROUND] Age-related immunosenescence, also known as 'inflammageing', may impact the elderly's ability to mount immune responses against cancers and compromise the effectiveness of immune checkpoint inhibition (ICI). In this context, data on tonsillar cancer (TC), a subset of head and neck squamous cell cancer (HNSCC), are lacking.
[AIMS/OBJECTIVES] To compare the presence/distribution and features of immune cells in TC, and of bulk RNA-seq in HNSCC, between the young and the elderly.
[MATERIAL AND METHODS] TC tissue microarrays (TMAs) characterised by GeoMx digital spatial profiling were revisited and analysed, focusing on quantification and location of CD8 and CD11c immune cells. analyses of the TMAs targeted CD68/CD163 macrophages. Bulk RNA-seq and clinical data from patients with HNSCC were sourced from the Cancer Genome Atlas (TCGA). For all data, patients were stratified into age groups.
[RESULTS] Immune-cell characteristics in TC were similar across young and elderly individuals, although the elderly exhibited higher PD-1 levels. TCGA data revealed increased immune checkpoint molecules PD-L1 and LAG-3 in the elderly, alongside immunosuppression.
[CONCLUSION AND SIGNIFICANCE] In the elderly, key immune cells are present in TC, and immune checkpoint molecules are overexpressed. This may be relevant to the stratification of patients for ICI.
[AIMS/OBJECTIVES] To compare the presence/distribution and features of immune cells in TC, and of bulk RNA-seq in HNSCC, between the young and the elderly.
[MATERIAL AND METHODS] TC tissue microarrays (TMAs) characterised by GeoMx digital spatial profiling were revisited and analysed, focusing on quantification and location of CD8 and CD11c immune cells. analyses of the TMAs targeted CD68/CD163 macrophages. Bulk RNA-seq and clinical data from patients with HNSCC were sourced from the Cancer Genome Atlas (TCGA). For all data, patients were stratified into age groups.
[RESULTS] Immune-cell characteristics in TC were similar across young and elderly individuals, although the elderly exhibited higher PD-1 levels. TCGA data revealed increased immune checkpoint molecules PD-L1 and LAG-3 in the elderly, alongside immunosuppression.
[CONCLUSION AND SIGNIFICANCE] In the elderly, key immune cells are present in TC, and immune checkpoint molecules are overexpressed. This may be relevant to the stratification of patients for ICI.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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