Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
61 participants (HBV n=20, HBV/HIV n=20, HIV n=21), on suppressive antiviral therapy, assessing transcriptomic and proteomic profiles, focusing on exhaustion markers alongside virus-specific functional capabilities.
I · Intervention 중재 / 시술
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C · Comparison 대조 / 비교
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O · Outcome 결과 / 결론
[CONCLUSIONS] People with well-controlled HBV/HIV co-infection maintain robust CD8 T cell responses with preserved stem-like properties supporting antiviral function. These results challenge assumptions about additive immune dysfunction in dual chronic infections and highlight the need for tailored immune-modulatory therapies.
[BACKGROUND] Chronic hepatitis B virus (HBV) infection disproportionately affects people living with HIV, who are often excluded from functional cure studies.
- 표본수 (n) 20
APA
Preechanukul A, Alrubayyi A, et al. (2025). Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection.. Gut. https://doi.org/10.1136/gutjnl-2025-335461
MLA
Preechanukul A, et al.. "Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection.." Gut, 2025.
PMID
41344698 ↗
Abstract 한글 요약
[BACKGROUND] Chronic hepatitis B virus (HBV) infection disproportionately affects people living with HIV, who are often excluded from functional cure studies.
[OBJECTIVE] This study investigates CD8 T cell profiles in HBV mono-infection versus HBV/HIV co-infection, examining the impact of long-term therapy on virus-specific responses to inform therapeutic strategies for immune restoration.
[DESIGN] We analysed CD8 T cell responses in 61 participants (HBV n=20, HBV/HIV n=20, HIV n=21), on suppressive antiviral therapy, assessing transcriptomic and proteomic profiles, focusing on exhaustion markers alongside virus-specific functional capabilities.
[RESULTS] Transcriptomic analysis revealed distinct signatures in co-infection, with upregulation of TCR signalling genes, inhibitory pathways and progenitor-exhausted markers (). This profile scored highly for a precursor exhausted (Tpex) CD8 T cell signature, reflecting stemness that maintains plasticity despite chronic antigen exposure. Proteomic analysis confirmed higher frequencies of Tpex (TCF-1CD127PD-1) CD8 T cells in co-infection, while HBV mono-infection showed predominance of terminally exhausted ToxTCF-1CD127 cells. Tpex enrichment extended to HBV-specific populations corresponding with more robust, polyfunctional HBV-specific responses in co-infection against surface and core antigens. HBV-specific CD8 T cells maintained enhanced proliferative capacity and checkpoint responsiveness to anti-PDL1 blockade compared with HBV mono-infection. While co-infection was characterised by lower HBsAg levels and longer treatment duration, these factors alone did not account for the distinct immunological profiles.
[CONCLUSIONS] People with well-controlled HBV/HIV co-infection maintain robust CD8 T cell responses with preserved stem-like properties supporting antiviral function. These results challenge assumptions about additive immune dysfunction in dual chronic infections and highlight the need for tailored immune-modulatory therapies.
[OBJECTIVE] This study investigates CD8 T cell profiles in HBV mono-infection versus HBV/HIV co-infection, examining the impact of long-term therapy on virus-specific responses to inform therapeutic strategies for immune restoration.
[DESIGN] We analysed CD8 T cell responses in 61 participants (HBV n=20, HBV/HIV n=20, HIV n=21), on suppressive antiviral therapy, assessing transcriptomic and proteomic profiles, focusing on exhaustion markers alongside virus-specific functional capabilities.
[RESULTS] Transcriptomic analysis revealed distinct signatures in co-infection, with upregulation of TCR signalling genes, inhibitory pathways and progenitor-exhausted markers (). This profile scored highly for a precursor exhausted (Tpex) CD8 T cell signature, reflecting stemness that maintains plasticity despite chronic antigen exposure. Proteomic analysis confirmed higher frequencies of Tpex (TCF-1CD127PD-1) CD8 T cells in co-infection, while HBV mono-infection showed predominance of terminally exhausted ToxTCF-1CD127 cells. Tpex enrichment extended to HBV-specific populations corresponding with more robust, polyfunctional HBV-specific responses in co-infection against surface and core antigens. HBV-specific CD8 T cells maintained enhanced proliferative capacity and checkpoint responsiveness to anti-PDL1 blockade compared with HBV mono-infection. While co-infection was characterised by lower HBsAg levels and longer treatment duration, these factors alone did not account for the distinct immunological profiles.
[CONCLUSIONS] People with well-controlled HBV/HIV co-infection maintain robust CD8 T cell responses with preserved stem-like properties supporting antiviral function. These results challenge assumptions about additive immune dysfunction in dual chronic infections and highlight the need for tailored immune-modulatory therapies.
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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