In Vitro Coculture Model of Immune and Tumor Cells for Immunotherapy Studies of High Mutational Load Tumors.
1/5 보강
To obtain a better tumor cell killing mediated by cytotoxic T lymphocytes (CTLs), several strategies were developed that might prime tumor-specific T-cell responses.
APA
Virág P, Brie I, Perde-Schrepler M (2026). In Vitro Coculture Model of Immune and Tumor Cells for Immunotherapy Studies of High Mutational Load Tumors.. Methods in molecular biology (Clifton, N.J.), 2959, 105-119. https://doi.org/10.1007/978-1-0716-4734-9_8
MLA
Virág P, et al.. "In Vitro Coculture Model of Immune and Tumor Cells for Immunotherapy Studies of High Mutational Load Tumors.." Methods in molecular biology (Clifton, N.J.), vol. 2959, 2026, pp. 105-119.
PMID
41028262 ↗
Abstract 한글 요약
To obtain a better tumor cell killing mediated by cytotoxic T lymphocytes (CTLs), several strategies were developed that might prime tumor-specific T-cell responses. One such strategy is combining the immune checkpoint inhibitors (CPI) blockade with radiotherapy (RT), considering the synergy between these two types of therapies. Here, we present an in vitro experimental model of cocultures of human tumor cell lines (A549 lung carcinoma and SK-Mel-1 melanoma) and immune cells (CTLs), in which CTLs activation is attempted by irradiation of the tumor cells with ionizing radiations and by the treatment of CTLs with an anti-programmed death-1 (anti-PD-1) drug. This model is suitable for studying cellular death, inflammatory responses, molecule expression, and immunotherapy.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Coculture Techniques
- Immunotherapy
- Cell Line
- Tumor
- T-Lymphocytes
- Cytotoxic
- Mutation
- Neoplasms
- Immune Checkpoint Inhibitors
- A549 Cells
- Lymphocyte Activation
- Cellular death
- Cocultures
- Cytotoxicity
- High mutational load tumors
- Immune checkpoint inhibitors
- Immunogenicity
- Inflammatory responses
- Programmed cell death protein
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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