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Unexpected complete resolution of intravesical inflammatory myofibroblastic tumor after immunotherapy for melanoma: A case report.

Urology case reports 2026 Vol.64() p. 103291

Lesgart M, Leonard S, Montanaro F, Helstrom E, Richer K, Keller A, Mackrides N, Kutikov A

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Inflammatory myofibroblastic tumors (IMT) are exceedingly rare, particularly when originating in the bladder.

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APA Lesgart M, Leonard S, et al. (2026). Unexpected complete resolution of intravesical inflammatory myofibroblastic tumor after immunotherapy for melanoma: A case report.. Urology case reports, 64, 103291. https://doi.org/10.1016/j.eucr.2025.103291
MLA Lesgart M, et al.. "Unexpected complete resolution of intravesical inflammatory myofibroblastic tumor after immunotherapy for melanoma: A case report.." Urology case reports, vol. 64, 2026, pp. 103291.
PMID 41377693

Abstract

Inflammatory myofibroblastic tumors (IMT) are exceedingly rare, particularly when originating in the bladder. Complete surgical resection is the gold standard treatment for IMTs. We describe a case of IMT of the urinary bladder that achieved complete radiographic and endoscopic resolution after systemic treatment with ipilimumab and nivolumab directed towards metastatic melanoma. This case is noteworthy due to the tumor's serendipitous and remarkable response to immunotherapy.