Soy isoflavone, Soyaflavone HG, improves low T cell proliferation response in aged BALB/c mice.

Aging is a phenomenon in which cells, tissues and organs undergo systemic pathological changes. We examined the effects of soy isoflavone on immune function in aged mice. Although aged mice showed lower T cell response against anti-CD3 monoclonal antibody stimulation than did young mice, aged mice have treated with soy isoflavone reversed the low responses. The percentage of CD4+ cells was higher in aged mouse splenocytes treated with soy isoflavone than in untreated mouse splenocytes. Unexpectantly, aged mice treated with soy isoflavone showed higher programmed cell death-1 expression on T cells than did aged control mice. These results showed that soy isoflavone improve low T cell proliferation response in aged mice. J. Med. Invest. 73 : 212-216, February, 2026.