Development of a Peptide-Based Photoimmunotherapy Drug Targeting PD-L1.
1/5 보강
Near-infrared photoimmunotherapy (NIR-PIT) has recently attracted attention as a highly selective cancer treatment, with good treatment outcomes observed from the only antibody-based drug currently av
APA
Otani T, Kondo N, et al. (2026). Development of a Peptide-Based Photoimmunotherapy Drug Targeting PD-L1.. Molecules (Basel, Switzerland), 31(2). https://doi.org/10.3390/molecules31020302
MLA
Otani T, et al.. "Development of a Peptide-Based Photoimmunotherapy Drug Targeting PD-L1.." Molecules (Basel, Switzerland), vol. 31, no. 2, 2026.
PMID
41599351 ↗
Abstract 한글 요약
Near-infrared photoimmunotherapy (NIR-PIT) has recently attracted attention as a highly selective cancer treatment, with good treatment outcomes observed from the only antibody-based drug currently available for clinical use. However, since only a single agent is currently used clinically and the development of new antibodies is costly, exploring other therapeutic modalities is important. In this study, we investigated a novel peptide-based PIT drug targeting programmed death-ligand 1 (PD-L1), which is overexpressed in many types of cancer. The WL12 peptide, which is known to bind to PD-L1, was conjugated with the photoabsorber IRDye700DX (IR700), and its usefulness was evaluated in vitro and in vivo. In therapeutic experiments on PD-L1-positive cells, NIR-PIT with WL12-IR700 induced PIT-like morphological changes in cells and reduced cancer cell viability in an NIR light dose- and drug concentration-dependent manner. In vivo experiments showed significant suppression of tumor growth and an extended overall survival rate. These results indicate that the developed peptide-based drug can be used for PD-L1-targeted NIR-PIT.
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