ICI-induced Granulomatous Sialadenitis is Responsive to Prednisone.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
sequential treatment with BRAF/MEK inhibitors followed by pembrolizumab
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Corticosteroid therapy reduced granuloma burden and improved salivary flow rates and tissue architecture; however, extensive fibrosis persisted despite treatment. These findings underscore the critical importance of early irAE recognition and intervention to preserve glandular function and enable continuation of cancer therapy.
Immune checkpoint inhibitors (ICIs) have transformed cancer treatment but commonly cause immune-related adverse events (irAEs), whether administered as monotherapy or in combination with other oncolog
APA
Kulchar RJ, Ogbonnaya-WhiDlesey A, et al. (2026). ICI-induced Granulomatous Sialadenitis is Responsive to Prednisone.. medRxiv : the preprint server for health sciences. https://doi.org/10.64898/2026.01.21.26344113
MLA
Kulchar RJ, et al.. "ICI-induced Granulomatous Sialadenitis is Responsive to Prednisone.." medRxiv : the preprint server for health sciences, 2026.
PMID
41646709 ↗
Abstract 한글 요약
Immune checkpoint inhibitors (ICIs) have transformed cancer treatment but commonly cause immune-related adverse events (irAEs), whether administered as monotherapy or in combination with other oncological agents. We present the first reported case of ICI-induced granulomatous sialadenitis in a male patient in his mid-fifties with BRAF-V600E-mutated papillary thyroid carcinoma who received sequential treatment with BRAF/MEK inhibitors followed by pembrolizumab. The patient experienced acute-onset severe xerostomia and salivary hypofunction, prompting ICI cessation and salivary gland biopsy. Integrative analysis using histology, single-cell RNA sequencing, and spatial transcriptomics revealed macrophage- and T-cell-mediated epithelial damage driven by epithelial senescence and Th1-polarized inflammation. Corticosteroid therapy reduced granuloma burden and improved salivary flow rates and tissue architecture; however, extensive fibrosis persisted despite treatment. These findings underscore the critical importance of early irAE recognition and intervention to preserve glandular function and enable continuation of cancer therapy.
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