Examining CD103 Tissue-Resident Memory T Cells in Nasopharyngeal Carcinoma.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
NanoString transcriptomic analysis
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Abundance of CD103 ITIC was not associated with improved survival (PMCC: HR = 0.9, 95% CI: 0.4-2.1) across all cohorts. [CONCLUSIONS] Despite similarities to other virally driven tumors, CD103 ITIC abundance was not prognostic in NPC, highlighting the need for better characterization of T subpopulations.
[BACKGROUND] Tissue-resident memory T cells (T), identified by CD103 expression, play key roles in infection and cancer and often correlate with improved survival in the latter.
- 표본수 (n) 30
- 95% CI 0.4-2.1
- HR 0.9
APA
Thai AA, Young RJ, et al. (2026). Examining CD103 Tissue-Resident Memory T Cells in Nasopharyngeal Carcinoma.. Head & neck, 48(2), 362-371. https://doi.org/10.1002/hed.70026
MLA
Thai AA, et al.. "Examining CD103 Tissue-Resident Memory T Cells in Nasopharyngeal Carcinoma.." Head & neck, vol. 48, no. 2, 2026, pp. 362-371.
PMID
40899222 ↗
Abstract 한글 요약
[BACKGROUND] Tissue-resident memory T cells (T), identified by CD103 expression, play key roles in infection and cancer and often correlate with improved survival in the latter. Their characterization in nasopharyngeal carcinoma (NPC) is of interest due to its viral etiology.
[METHODS] NPC tumors from patients treated at Peter MacCallum Cancer Centre (PMCC; 2000-2017) were examined for CD103, CD8 T cells, and PD-L1 abundance, correlated with survival, and underwent NanoString transcriptomic analysis. Additional cohorts from Hong Kong and Singapore were assessed for CD103 intra-tumoral immune cell (ITIC) abundance.
[RESULTS] Of the 141 PMCC patients, 29% (n = 30/103) of NPC tumors had high CD103 ITIC (defined as ≥ 30%) linked with T gene expression, immune checkpoints, and upregulated pathways in T-cell activation. Abundance of CD103 ITIC was not associated with improved survival (PMCC: HR = 0.9, 95% CI: 0.4-2.1) across all cohorts.
[CONCLUSIONS] Despite similarities to other virally driven tumors, CD103 ITIC abundance was not prognostic in NPC, highlighting the need for better characterization of T subpopulations.
[METHODS] NPC tumors from patients treated at Peter MacCallum Cancer Centre (PMCC; 2000-2017) were examined for CD103, CD8 T cells, and PD-L1 abundance, correlated with survival, and underwent NanoString transcriptomic analysis. Additional cohorts from Hong Kong and Singapore were assessed for CD103 intra-tumoral immune cell (ITIC) abundance.
[RESULTS] Of the 141 PMCC patients, 29% (n = 30/103) of NPC tumors had high CD103 ITIC (defined as ≥ 30%) linked with T gene expression, immune checkpoints, and upregulated pathways in T-cell activation. Abundance of CD103 ITIC was not associated with improved survival (PMCC: HR = 0.9, 95% CI: 0.4-2.1) across all cohorts.
[CONCLUSIONS] Despite similarities to other virally driven tumors, CD103 ITIC abundance was not prognostic in NPC, highlighting the need for better characterization of T subpopulations.
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