LAG-3 Regulatory T Cells Suppress Effector Function of T Cells and Allow Their Proliferation Into Regulatory T Cells.
1/5 보강
LAG-3 regulatory T cells suppress the effector but not the proliferative response of naïve cognate antigen-specific CD4 T cells in vivo.
APA
Dutta A, Miaw SC, et al. (2026). LAG-3 Regulatory T Cells Suppress Effector Function of T Cells and Allow Their Proliferation Into Regulatory T Cells.. Immunology, 177(2), 317-328. https://doi.org/10.1111/imm.70046
MLA
Dutta A, et al.. "LAG-3 Regulatory T Cells Suppress Effector Function of T Cells and Allow Their Proliferation Into Regulatory T Cells.." Immunology, vol. 177, no. 2, 2026, pp. 317-328.
PMID
41060370 ↗
Abstract 한글 요약
LAG-3 regulatory T cells suppress the effector but not the proliferative response of naïve cognate antigen-specific CD4 T cells in vivo. The Th1, Th2, and Th17 machineries in the suppressed CD4 T cells are impaired. Genomic study of the suppressed T cells revealed enhanced T cell receptor signalling with up-regulation of immune checkpoints, including PD-1 and PD-L1, and down-regulation of pro-inflammatory pathways. Although oxidative metabolism is reduced, the suppressed T cells retain proliferative capacity and acquire LAG-3 expression with proliferation. They acquire the capacity of LAG-3 regulatory T cells. They inhibit the IFN-γ response of co-cultured naïve CD4 T cells in vitro. Upon adoptive transfer, they rescue mice from lethal autoimmune pulmonitis in a dose-dependent manner. Our results implied a mechanism for the maintenance of long-lasting antigen-specific tolerance.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Animals
- T-Lymphocytes
- Regulatory
- Cell Proliferation
- Mice
- Lymphocyte Activation Gene 3 Protein
- Lymphocyte Activation
- Antigens
- CD
- Immune Tolerance
- Inbred C57BL
- Adoptive Transfer
- Programmed Cell Death 1 Receptor
- Cells
- Cultured
- Signal Transduction
- B7-H1 Antigen
- Interferon-gamma
- Receptors
- Antigen
- T-Cell
- LAG‐3+ aTreg cell
- effector function‐suppressed proliferation
- hemagglutinin‐specific CD4+ T cells
… 외 1개
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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