Alterations of mucosal-associated invariant T cells in dermatomyositis.
[OBJECTIVES] The aim of this study is to investigate the frequency and functional changes of mucosal-associated invariant T (MAIT) cells in the peripheral blood of patients with dermatomyositis (DM).
APA
Ye S, Du J, et al. (2026). Alterations of mucosal-associated invariant T cells in dermatomyositis.. Clinical and experimental rheumatology, 44(2), 273-278. https://doi.org/10.55563/clinexprheumatol/vp3uim
MLA
Ye S, et al.. "Alterations of mucosal-associated invariant T cells in dermatomyositis.." Clinical and experimental rheumatology, vol. 44, no. 2, 2026, pp. 273-278.
PMID
41562362
Abstract
[OBJECTIVES] The aim of this study is to investigate the frequency and functional changes of mucosal-associated invariant T (MAIT) cells in the peripheral blood of patients with dermatomyositis (DM).
[METHODS] Peripheral blood mononuclear cells (PBMCs) from 23 untreated DM patients and 32 healthy controls (HC) were analysed via flow cytometry to assess MAIT cell frequency, activation status, chemokine receptor expression, and cytokine production.
[RESULTS] The frequency of circulating MAIT cells was significantly decreased in the DM group compared with the HC group, while the proportion of CD69+ and PD-1+ MAIT cells was significantly increased, especially in patients with melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5-DM). Moreover, the expression of the chemokine receptors CCR2 and CCR5 on MAIT cells was reduced in DM patients. In addition, the proportion of IFN-γ+ MAIT cells was significantly elevated in DM patients.
[CONCLUSIONS] The reduced frequency of MAIT cells in DM may be associated with excessive activation. The increased secretion of IFN-γ by MAIT cells may contribute to DM pathogenesis.
[METHODS] Peripheral blood mononuclear cells (PBMCs) from 23 untreated DM patients and 32 healthy controls (HC) were analysed via flow cytometry to assess MAIT cell frequency, activation status, chemokine receptor expression, and cytokine production.
[RESULTS] The frequency of circulating MAIT cells was significantly decreased in the DM group compared with the HC group, while the proportion of CD69+ and PD-1+ MAIT cells was significantly increased, especially in patients with melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5-DM). Moreover, the expression of the chemokine receptors CCR2 and CCR5 on MAIT cells was reduced in DM patients. In addition, the proportion of IFN-γ+ MAIT cells was significantly elevated in DM patients.
[CONCLUSIONS] The reduced frequency of MAIT cells in DM may be associated with excessive activation. The increased secretion of IFN-γ by MAIT cells may contribute to DM pathogenesis.
MeSH Terms
Humans; Mucosal-Associated Invariant T Cells; Dermatomyositis; Male; Female; Middle Aged; Case-Control Studies; Adult; Lymphocyte Activation; Interferon-gamma; Receptors, CCR2; Aged; Antigens, CD; Programmed Cell Death 1 Receptor; Interferon-Induced Helicase, IFIH1; Lectins, C-Type; Antigens, Differentiation, T-Lymphocyte; Flow Cytometry; Biomarkers; Cytokines; Receptors, CCR5
같은 제1저자의 인용 많은 논문 (5)
- Prognostic value of combined digital PCR and multiparametric flow cytometry monitoring MRD in non-transplant acute myeloid leukemia.
- MUTE-Seq: An Ultrasensitive Method for Detecting Low-Frequency Mutations in cfDNA With Engineered Advanced-Fidelity FnCas9.
- Successful endoscopic duodenal stent placement for afferent loop obstruction following Billroth II gastrectomy: a case report.
- Plant and probiotic-based edible vaccines for Helicobacter pylori: Research status and application prospects.
- Letter to the editor for the article "Impact of postoperative complications on gastric cancer survival".