Salvage Surgery Following Definitive Chemoradiotherapy and Immune Checkpoint Inhibitor Therapy for Locally Advanced Thymic Carcinoma.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
durvalumab, which reduced the primary tumour size and resolved lymphadenopathy, without immune-related adverse events
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
The patient remained disease-free at 2 years postoperatively. Salvage surgery following immune checkpoint inhibitor therapy may be a viable treatment option for thymic carcinoma with high programmed cell death-ligand 1 expression.
Surgical resection improves prognosis for thymic carcinoma.
APA
Tokuda R, Ikebe S, et al. (2026). Salvage Surgery Following Definitive Chemoradiotherapy and Immune Checkpoint Inhibitor Therapy for Locally Advanced Thymic Carcinoma.. Interdisciplinary cardiovascular and thoracic surgery, 41(2). https://doi.org/10.1093/icvts/ivag031
MLA
Tokuda R, et al.. "Salvage Surgery Following Definitive Chemoradiotherapy and Immune Checkpoint Inhibitor Therapy for Locally Advanced Thymic Carcinoma.." Interdisciplinary cardiovascular and thoracic surgery, vol. 41, no. 2, 2026.
PMID
41669790 ↗
Abstract 한글 요약
Surgical resection improves prognosis for thymic carcinoma. Recent phase II trials have indicated the efficacy of immune checkpoint inhibitor therapy in unresectable disease. Here, we report a case of salvage surgery following immune checkpoint inhibitor therapy for an initially unresectable, locally advanced thymic carcinoma in a 67-year-old woman. Computed tomography revealed an anterior mediastinal mass and enlarged anterior mediastinal lymph nodes, diagnosed as an unresectable thymic epithelial tumour, due to suspected invasion into the left main pulmonary artery. Thoracoscopic biopsy confirmed the diagnosis of squamous cell carcinoma with high programmed cell death-ligand 1 expression (90%-100%). Following definitive chemoradiotherapy, the patient received durvalumab, which reduced the primary tumour size and resolved lymphadenopathy, without immune-related adverse events. Salvage surgery was performed without invasion of the great vessels. The patient remained disease-free at 2 years postoperatively. Salvage surgery following immune checkpoint inhibitor therapy may be a viable treatment option for thymic carcinoma with high programmed cell death-ligand 1 expression.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Female
- Salvage Therapy
- Aged
- Immune Checkpoint Inhibitors
- Thymus Neoplasms
- Chemoradiotherapy
- Thymoma
- Treatment Outcome
- Antibodies
- Monoclonal
- B7-H1 Antigen
- Carcinoma
- Squamous Cell
- Neoplasms
- Glandular and Epithelial
- immune checkpoint inhibitors
- programmed cell death-ligand 1
- salvage surgery
- thymic carcinoma
- thymic epithelial tumour
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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