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Virus-Specific T Cells and Response to Checkpoint Inhibitors in Progressive Multifocal Leukoencephalopathy.

1/5 보강

JAMA neurology 2026 Vol.83(3) p. 280-289 OA

PICO 자동 추출 (휴리스틱, conf 3/4)

P · Population 대상 환자/모집단

111 patients with PML who were treated with ICIs stratified by peripheral virus-specific T cell presence (ELISpot/flow cytometry) between August 2021 and May 2024, with a median (IQR) follow-up of 7 (1-13) months.

I · Intervention 중재 / 시술

pembrolizumab (n = 81), nivolumab (n = 28), or atezolizumab (n = 2) per availability and prescribing practices at participating centers

C · Comparison 대조 / 비교

추출되지 않음

O · Outcome 결과 / 결론

[CONCLUSIONS AND RELEVANCE] Preexisting functional virus-specific T cells were associated with better clinical response, longer survival, and lower toxicity in PML. These findings suggest the likely importance of preexisting antiviral immunity for successful ICI therapy.

Möhn N, Grote-Levi L, Bonifacius A, Tischer-Zimmermann S, Nay S, Jendretzky KF

📖 무료 전문 🟢 PMC 전문 PMC12820779 🔓 OA PDF unpaywall · cc-by

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