Successful Treatment of Paranasal Sinus Metastasis From Renal Cell Carcinoma With Immune Checkpoint Inhibitors and Radiotherapy: A Case Report.
[INTRODUCTION] Renal cell carcinoma (RCC) metastasis to the paranasal sinuses is rare and lacks standard treatment, particularly for unresectable tumors.
APA
Yamada S, Matsuo T, et al. (2026). Successful Treatment of Paranasal Sinus Metastasis From Renal Cell Carcinoma With Immune Checkpoint Inhibitors and Radiotherapy: A Case Report.. IJU case reports, 9(2), e70156. https://doi.org/10.1002/iju5.70156
MLA
Yamada S, et al.. "Successful Treatment of Paranasal Sinus Metastasis From Renal Cell Carcinoma With Immune Checkpoint Inhibitors and Radiotherapy: A Case Report.." IJU case reports, vol. 9, no. 2, 2026, pp. e70156.
PMID
41726848
Abstract
[INTRODUCTION] Renal cell carcinoma (RCC) metastasis to the paranasal sinuses is rare and lacks standard treatment, particularly for unresectable tumors. We report a case of sphenoid sinus metastasis with sarcomatoid differentiation successfully managed with radiation therapy and immunotherapy.
[CASE PRESENTATION] A 59-year-old male who had undergone left radical nephrectomy for RCC 13 years prior presented with acute left eye pain and tinnitus. Contrast-enhanced computed tomography (CT) revealed a hyper vascular sphenoid sinus mass with osseous destruction. Biopsy confirmed metastatic RCC with sarcomatoid differentiation. Given rapid symptom progression, intensity-modulated radiation therapy (39 Gy in 13 fractions) was initiated, followed by immunotherapy with nivolumab and ipilimumab. The patient developed complete blindness, which gradually improved during treatment. Serial CT showed a partial response sustained through four cycles. Subsequent 37 cycles of maintenance nivolumab showed persisting tumor reduction.
[CONCLUSION] Radiation with nivolumab and ipilimumab may be effective for unresectable paranasal sinus metastases of RCC.
[CASE PRESENTATION] A 59-year-old male who had undergone left radical nephrectomy for RCC 13 years prior presented with acute left eye pain and tinnitus. Contrast-enhanced computed tomography (CT) revealed a hyper vascular sphenoid sinus mass with osseous destruction. Biopsy confirmed metastatic RCC with sarcomatoid differentiation. Given rapid symptom progression, intensity-modulated radiation therapy (39 Gy in 13 fractions) was initiated, followed by immunotherapy with nivolumab and ipilimumab. The patient developed complete blindness, which gradually improved during treatment. Serial CT showed a partial response sustained through four cycles. Subsequent 37 cycles of maintenance nivolumab showed persisting tumor reduction.
[CONCLUSION] Radiation with nivolumab and ipilimumab may be effective for unresectable paranasal sinus metastases of RCC.
같은 제1저자의 인용 많은 논문 (5)
- Prognostic discrepancies between surgery-first and neoadjuvant-treated resected pancreatic cancer in the same pathological stage.
- Successful Treatment of Granulocyte Colony-Stimulating Factor-Related Aortitis in Prostate Cancer.
- Effect of TU-100 on Colorectal Liver Metastasis in Mouse Model of MASH.
- Perforated Small Intestinal Diffuse Large B-Cell Lymphoma Successfully Managed With Surgical Resection and Staged Introduction of Polatuzumab Vedotin-Based Chemotherapy.
- Clinical Impact for Prognostic Index of Nodal Stations and Reconsideration of Optimal Regional Lymph Node Station in Pancreatic Cancer.